How GLP-1 Went From Biology to Blockbuster
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How GLP-1 Went From Biology to Blockbuster
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How did a gut hormone that disappeared in seconds become one of the biggest drug classes in the world?
In this episode, I walk through the story of GLP-1, from early scientific discovery and the Gila monster breakthrough to Novo Nordisk’s drug design strategy, Eli Lilly’s competitive push, and the shift that turned GLP-1 from a diabetes treatment into something much bigger.
This is a story about how a hard biological problem became a pharmaceutical platform, and how that platform began to change the way medicine thinks about obesity, metabolism, and chronic disease.
Timestamps
- 00:08 Intro: The 90-Second Hormone
- 02:23 The Gut’s Hidden Signal
- 05:01 The Discovery of GLP-1
- 10:32 The Gila Monster Breakthrough
- 16:04 Novo Solves the Delivery Problem
- 19:43 How GLP-1 Became a Platform
- 25:46 Beyond Diabetes
- 30:28 Lilly Raises the Benchmark
- 32:43 The Broader Implications of GLP-1
- 43:22 The future of GLP-1
- 49:14 When the Science Meets the System
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