HOST: Hildy Grossman CO-HOST, Jordan Rich

Guests: Justin Gainor, MD, Director of Targeted Immunotherapy at the Massachusetts General Hospital and David Barbie, MD, Director of the Barbie Lab at Dana Farber Cancer Institute Targeting Innate Immunity in Cancer

Lung cancer has long been one of the most complex and difficult cancers to treat. But what if we could outsmart it—not just with surgery, chemotherapy, or radiation, but by training the immune system itself? This episode explores a revolutionary question: Could a vaccine change the future of lung cancer? To shed light on answers to this question are Dr. Justin Gainor, whose interest is in vaccine development, and Dr. David Barbie, who returns to Backstage @ Upstage to explain how the immune system responds to cancer. Our renowned guests describe the challenges of creating a therapeutic vaccine and why a preventative vaccine is less likely to succeed. They detail how the immune system’s delicate operations need to be understood to successfully develop a vaccine to treat lung cancer. Moreover, you’ll want to hear about the groundbreaking promise of “personalized vaccines” tailored to an individual’s unique genomic markers, and how these cutting-edge vaccines will change the future of oncology forever.