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Behind the Breakthroughs

Behind the Breakthroughs

Written by: Inside Precision Medicine
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Join host Jonathan D. Grinstein, PhD, North American Editor for Inside Precision Medicine, as he uncovers the stories behind the pioneers driving the precision medicine revolution. Behind the Breakthroughs features candid interviews with seasoned veterans and rising stars, exploring their origin stories and groundbreaking contributions advancing the frontiers of patient diagnosis, treatment, and care.


In every episode, Jonathan goes beyond the science, diving deep into the personal and professional journeys of those striving to make these incredible new therapies more equitable and accessible globally. You'll discover how emerging technologies in molecular diagnostics, next-generation sequencing, genetic medicines (e.g., cell and gene therapies), and AI/ML are transforming treatment and bringing precision medicine closer to the forefront of healthcare. Whether you’re a researcher at a large pharma company or small biotech startup, a clinician at a major health system or community setting, a laboratory technician in the clinic or academia, an investor at a premier or venture capital firm, or just interested in the latest in medicine and healthcare, these interviews will inspire and inform you about personalized medicine's future.

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Episodes
  • Jurgi Camblong: Data-Driven Doctors Without Borders

    Jurgi Camblong: Data-Driven Doctors Without Borders
    Apr 22 2026

    Precision medicine promises individualized care through data, but progress remains fragmented. Clinical, genomic, and imaging data are siloed, limiting real-world use. Jurgi Camblong, PhD, founded SOPHiA Genetics to integrate multimodal data into actionable insights, yet variability in technologies and evolving biology complicate standardization. In this episode of Behind the Breakthroughs, Camblong discusses how effective solutions require combining diverse AI methods grounded in context and longitudinal feedback loops. To Camblong, the challenge is not data quantity but making existing information usable in patient care.


    Produced and hosted by Jonathan D. Grinstein, PhD

    Audio mixed and mastered by Erick Ziegler

    Brought to you by Inside Precision Medicine (SAGE Publishing)

    Hosted on Acast. See acast.com/privacy for more information.
    Show More Show Less
    1 hr and 1 min
  • Molly Gibson: Superintelligence and the Future of Drug Development

    Molly Gibson: Superintelligence and the Future of Drug Development
    Apr 8 2026

    As an Origination Partner at Flagship Pioneering, Molly Gibson, PhD, co-founded her first company, Generate:Biomedicines, in 2018, where she made her mark by developing models that design novel proteins—work that has already led to a Phase 3 asthma drug. Since then, she has gone on to co-found two additional companies: Expedition Medicines and Lila Biosciences. In this episode, Molly explains why the anticipated boom in AI-guided drug development hasn’t fully materialized and how she’s tackling the challenge by modeling complex chemistry to synthesize novel small molecules at Expedition Medicines. She also discusses building "superintelligence" and closed-loop systems in which AI can autonomously generate, test, and refine scientific ideas at Lila Biosciences.



    Produced and hosted by Jonathan D. Grinstein, PhD

    Audio mixed and mastered by Erick Ziegler

    Brought to you by Inside Precision Medicine (SAGE Publishing)

    Hosted on Acast. See acast.com/privacy for more information.
    Show More Show Less
    51 mins
  • Mike Curtis: Pig Organs as a Bridge to Human Transplants

    Mike Curtis: Pig Organs as a Bridge to Human Transplants
    Mar 25 2026

    Xenotransplantation has long been a scientifically promising but ethically complex field, overshadowed by its limited practicality despite the growing shortage of transplantable organs and the urgent needs of patients. Recent breakthroughs, including genetically modified pig heart transplants in 2022 and 2023, have demonstrated its feasibility, marking a turning point even though long-term survival has not yet been achieved. In this episode of Behind the Breakthroughs, Mike Curtis, PhD, President and CEO of eGenesis, explains how the company is building on this success to advance xenotransplantation as a scalable clinical strategy, emphasizing that even temporary extensions of life—such as a recent nine-month kidney transplant case—can provide meaningful outcomes and bridge patients to future treatments.


    Produced and hosted by Jonathan D. Grinstein, PhD

    Audio mixed and mastered by Erick Ziegler

    Brought to you by Inside Precision Medicine (SAGE Publishing)


    Hosted on Acast. See acast.com/privacy for more information.
    Show More Show Less
    52 mins
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