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Building The Impossible with Jocelyn Houle

Building The Impossible with Jocelyn Houle

Written by: Startmachina
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About this listen

This podcast is for technical and scientific founders in Data, Energy, Defense, Agriculture, Aerospace, and Deep Tech who want to turn new ideas into reality. The AI-innovation cycle doesn't use the old rules to scale, so how will really big ideas move from lab to launch to full diffusion? From bio-inspired drones mimicking insect movement, to quantum computing breakthroughs and climate tech moonshots; we help scientific founders, buyers, investors and regulators collaborate to source scalable ideas, go to market, and think through impossible ideas with clear frameworks.Copyright 2025 Startmachina Economics Leadership Management & Leadership Science
Episodes
  • Build vs. Buy: Can Hospitals Train Their Own Diagnostic AI?
    Aug 18 2025

    In this podcast episode, host Jolyn interviews technical founder Dmitri Krylov, who discusses his startup DX Composer ai. The platform aims to enable clinicians and researchers to create their own AI diagnostic tools, focusing on enhancing the accuracy and accessibility of medical diagnostics, particularly in complex cases like rare cancers. Dmitri shares his background in both life sciences and software engineering, highlighting the challenges and differences between academic and industrial coding. He also elaborates on the potential benefits of AI in reducing misdiagnosis and improving clinical outcomes, emphasizing the importance of continual learning and adapting to new data.

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    55 mins
  • Moneyball for Data - RootCause.ai
    Jul 27 2025

    Causal Inference: The Future of Business Analytics with Ayman Elhalwagy

    NOTE: Perceptura changed its name and logo to RootCause! Sorry for any confusion!

    Be sure to book a demo here: https://rootcause.ai/


    In this episode of Building the Impossible with Jocelyn Houle, Jocelyn interviews Ayman Elhalwagy, CEO and founder of Perceptura, recently rebranded as RootCause.ai.


    Ayman describes the company’s causal inference engine, which he likened to a 'Moneyball for business,' b/c it uncovers meaningful insights from data across entire estates. The discussion covers Ayman's transition from academia to entrepreneurship, the unique challenges of applying scientific principles to commercial environments, and the role of resilience and integrity in a founder's journey.



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    53 mins
  • Rob Demillo - Next Gen Compute in Space with Sophia Space
    Jul 13 2025

    In this episode of 'Building The Impossible,' host Jocelyn Houle talks with Rob DeMilo, CEO of Sophia Space and venture partner at Spark Labs Global. Rob shares his unique journey from working at NASA and MIT to becoming a serial entrepreneur with seven exits and IPOs. He discusses the necessity of shifting from a scientific to a CEO mindset, the challenges of innovating in space, and the future of deep tech that’s worth investing in. Rob's current venture, Sophia Space, aims to move cloud servers into orbit, addressing issues like power consumption and cooling by using space as a solution. They’re developing self-sustaining, modular servers called tiles designed to function efficiently in space, offering applications ranging from missile tracking to real-time weather prediction. Rob emphasizes the importance of building one working component first and maintaining a unified hardware-software approach to ensure success. This episode is a deep dive into the future of computing and the strategic steps needed to go from lab to launch successfully.

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    47 mins
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