Greg speaks with three leaders in mental health philanthropy: Alyson Nieman from Mindful Philanthropy, Sabrina Gracias from Ortus Foundation, and Christena Huntsman Durham from Huntsman Mental Health Foundation, each offering a distinct perspective on how funding decisions get made and where the biggest gaps remain.

In this episode we discuss:

• Trends in mental health philanthropy, and the 10-year challenge: how the field moves from roughly $2B to $35B in annual funding.
• Funding the clinic of the future: a $150M philanthropic gift behind the Huntsman Mental Health Institute’s crisis care center
• Youth mental health: how the Ortus Foundation is addressing regional gaps in the US Intermountain West

Credits:

Created by Greg Kubin and Matias Serebrinsky
Host: Greg Kubin
Produced by Caitlin Ner & Nico V. Rey

Find us at businesstrip.fm and psymed.ventures
Follow us on Instagram and Twitter!
Theme music by Dorian Love
Additional Music: Distant Daze by Zack Frank

Greg interviews Rick Perry, the former Governor of Texas and former U.S. Secretary of Energy and leading advocate for ibogaine, live at the Real Summit.

In this episode, we discuss:

• How a former Texas governor moved from strict opposition to drugs to becoming a leading advocate for ibogaine after firsthand experience and veteran outcomes.
• Ibogaine’s impact on PTSD, opioid addiction, and traumatic brain injury, including Stanford-linked brain imaging data showing functional and structural improvement.
• How veterans are the proving ground that enabled Texas to commit $50M in public funding for ibogaine clinical trials.
• Why ibogaine requires intensive medical supervision and why rigorous trials are essential for legitimacy and scale.
• A vision where ibogaine reshapes addiction treatment, veteran care, and eventually criminal justice and homelessness policy.

Credits:

Created by Greg Kubin and Matias Serebrinsky
Host: Greg Kubin
Produced by Caitlin Ner & Nico V. Rey

Find us at businesstrip.fm and psymed.ventures
Follow us on Instagram and Twitter!
Theme music by Dorian Love
Additional Music: Distant Daze by Zack Frank

Matias interviews James (Jim) Gorman MD PhD from the Wyss Institute. Jim is Principal Investigator on the Wyss Institute Brain Targeting Program (BTP). Jim leads a team developing new approaches to transport drugs through the blood brain barrier (BBB) into the CNS.

In this episode, we discuss:

• Why the BBB blocks most modern drugs from entering the brain, creating the biggest bottleneck in neuro
• How brain shuttles hijack natural transport pathways like the transferrin receptor to move drugs across the BBB
• How new modalities that reach the brain can potentially treat diseases like Alzheimer’s, Parkinson’s, ALS, and lysosomal disorders
• Why delivery route of shuttles enable IV or subcutaneous dosing instead of invasive intrathecal injections
• How early data shows that shuttle-enabled antibodies clear amyloid faster, at lower doses, and with fewer side effects
• How the field is accelerating through a pre-competitive consortium model that lets multiple companies share shuttle platforms

Credits:

Created by Greg Kubin and Matias Serebrinsky
Host: Matias Serebrinsky
Produced by Caitlin Ner & Nico V. Rey

Find us at businesstrip.fm and psymed.ventures
Follow us on Instagram and Twitter!
Theme music by Dorian Love
Additional Music: Distant Daze by Zack Frank