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Corneal Collagen Cross-Linking

Corneal Collagen Cross-Linking

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Episode 40 - Corneal Collagen Cross-LinkingWelcome back to Basic Sciences in Ophthalmology. Iam Dr Thomas Whitelaw and in todays episode of the podcast we break down complex ophthalmic science into practical, exam-friendly concepts.

In today’s episode, we’re exploring Corneal Collagen Cross-Linking, one of the most important modern developments in corneal biomechanics and keratoconus management.

Cross-linking is fascinating because it sits right at the intersection of physics, photochemistry, corneal biology, and refractive surgery. It uses ultraviolet light, a photosensitiser, and controlled oxidative reactions to strengthen the cornea and halt ectatic progression.

We’ll break today’s episode into three sections:

Mechanism of cross-linking

Riboflavin absorption

Protocols and safety considerations

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