Diabetes Ups Myocarditis Heart Failure Risk 02/23/26

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Diabetes Ups Myocarditis Heart Failure Risk 02/23/26

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Welcome to Cardiology Today – Recorded February 23, 2026. This episode summarizes 5 key cardiology studies on topics like antiplatelet therapy and longitudinal study. Key takeaway: Diabetes Ups Myocarditis Heart Failure Risk. Article Links: Article 1: Elevated Activin-A serum levels in patients with acute peripartum cardiomyopathy and during left ventricular recovery. (ESC heart failure) Article 2: Diabetes Increases the Risk of Heart Failure in Myocarditis: A Propensity-Matched Nationwide Database Analysis. (ESC heart failure) Article 3: Nomogram Model for Predicting 90-Day Excellent Outcome in Patients With Acute Vertebrobasilar Artery Occlusion Undergoing Endovascular Thrombectomy. (Journal of the American Heart Association) Article 4: Insomnia and Incident Cardiovascular Disease in US Hispanic/Latino Adults: Results From HCHS/SOL. (Journal of the American Heart Association) Article 5: Safety and Efficacy of Early Aspirin Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT): Rationale and Design of a Multicenter, Randomized, Placebo-Controlled Clinical Trial. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/diabetes-ups-myocarditis-heart-failure-risk-02-23-26/ Featured Articles Article 1: Elevated Activin-A serum levels in patients with acute peripartum cardiomyopathy and during left ventricular recovery. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41728898 Summary: This study analyzed Activin-A serum levels in patients from the German Peripartum Cardiomyopathy registry both at acute diagnosis and during Left Ventricular recovery. It found that elevated circulating levels of Activin-A, a senescence-associated secretory phenotype factor, correlated with heart failure severity in acute Peripartum Cardiomyopathy patients at baseline. The investigation detailed the trajectory of Activin-A serum levels throughout the course of Left Ventricular functional recovery. This analysis highlights Activin-A as a potential biomarker relevant to the pathophysiology and recovery assessment in Peripartum Cardiomyopathy. Article 2: Diabetes Increases the Risk of Heart Failure in Myocarditis: A Propensity-Matched Nationwide Database Analysis. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41728893 Summary: This propensity-matched nationwide database analysis found that diabetes significantly increased the risk of heart failure in patients hospitalized for myocarditis. The study reported that diabetes impacted both in-hospital and long-term outcomes in this patient group. Patients discharged alive were followed for a calendar year, demonstrating the sustained effect of diabetes on subsequent cardiac events. This analysis establishes diabetes as a critical comorbidity that exacerbates adverse outcomes in myocarditis. Article 3: Nomogram Model for Predicting 90-Day Excellent Outcome in Patients With Acute Vertebrobasilar Artery Occlusion Undergoing Endovascular Thrombectomy. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717945 Summary: This study developed and externally validated a nomogram model designed to predict 90-day excellent functional outcomes in patients with acute vertebrobasilar artery occlusion. The nomogram provides a crucial tool for patient selection in endovascular thrombectomy, a procedure proven effective for this condition which typically has mortality rates up to 80 percent. The model offers enhanced precision in identifying patients most likely to achieve a modified Rankin Scale score of 0-1 at 90 days. This predictive model addresses the significant challenge of patient selection in managing acute vertebrobasilar artery occlusion. Article 4: Insomnia and Incident Cardiovascular Disease in US Hispanic/Latino Adults: Results From HCHS/SOL. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717941 Summary: This study analyzed data from 3635 Hispanic/Latino adults and found a significant association between insomnia and incident cardiovascular disease. Insomnia was assessed using the Women’s Health Initiative Insomnia Rating Scale, evaluating group status, symptom severity, specific symptom dimensions, and sleep duration at baseline. The results demonstrated that insomnia is an independent cardiovascular risk factor in this specific demographic. This highlights the importance of screening for and managing insomnia to potentially mitigate cardiovascular risk in Hispanic/Latino populations. Article 5: Safety and Efficacy of Early Aspirin Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT): Rationale and Design of a Multicenter, Randomized, Placebo-Controlled Clinical Trial. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717940 Summary: The TREND-IVT trial is a multicenter, randomized,...

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