Chapters:
00:00 - Introduction & AMA Catch-up
00:28 - Does Fibromyalgia Affect Heart Health?
01:43 - Advanced Markers for Inflammation (hsCRP, oxLDL)
03:04 - Upcoming LIVE AMA Details
03:48 - Is it Safe to Stop Lipitor for High Cholesterol?
05:23 - The "700 Point Drop" in CAC Score: What is Plaque-X?
07:51 - Testosterone & The FDA Black Box Warning Update
08:33 - Deep Dive: Do Viagra and Cialis Impact Mortality?
09:54 - Study Funding and Conflicts of Interest
10:51 - How PDE5 Inhibitors Actually Work
12:53 - Observational Studies vs. Clinical Trials
14:41 - Understanding the Dataset (TriNetX)
16:41 - How Patient Cohorts are Defined
19:54 - Comparing Cialis vs. Viagra for Heart Benefits
21:26 - Why Prostate Health Matters in This Research
24:21 - Breaking Down the Five Key Outcomes
26:30 - Statistical Matching: Making the Groups Fair
30:03 - The Results: Mortality, Stroke, and Dementia Risk
33:57 - Absolute vs. Relative Risk Reduction
37:29 - Tadalafil’s Half-Life Advantage
39:18 - Crossing the Blood-Brain Barrier
41:04 - Study Limitations: What We Might Have Missed
42:24 - The "Partnership" Factor in Longevity Data 43:32 - Final Thoughts: Is it Time for a Label Change?

In this session, I'm diving into your questions from our last AMA and taking a deep look at a fascinating new study on PDE5 inhibitors like Cialis (tadalafil) and Viagra (sildenafil). We explore whether these medications could have a role in longevity, heart health, and even dementia prevention. I also address questions on fibromyalgia, stopping statins, and the latest on testosterone and cardiovascular risk.

Sign up for more information on my own practice here: https://corsighthealth.com/

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🧬 About Dr. Lily Johnston

Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.

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