In this episode of Facing the Cancer Revolution Podcast we discuss Multiple myeloma cancer and new CAR-T Treatments for bone marrow cancers.

Multiple myeloma is a type of blood cancer that affects plasma cells, which are a type of white blood cells that produce antibodies to help fight infections. Treatment options for multiple myeloma have improved significantly in recent years with the introduction of new drugs and therapies.

• Immunomodulatory Drugs (IMiDs): boost the immune system and target cancer cells. .
• Proteasome inhibitors: Proteasomes are enzymes that break down proteins in cells, including those that cause cancer cells to grow.
• Monoclonal antibodies: These are drugs that target specific proteins on the surface of cancer cells. .
• CAR T-cell therapy: This is a type of immunotherapy where T cells (a type of immune cell) are modified in a laboratory to produce chimeric antigen receptors (CARs) that recognize and attack cancer cells.
• High-dose chemotherapy and stem cell transplant: This treatment involves high-dose chemotherapy to kill cancer cells followed by a stem cell transplant to replace the damaged cells.
• Targeted therapy: This is a type of treatment that targets specific molecules or genes that are involved in the growth and survival of cancer cells. .

Resources Discussed in Podcast

https://www.dana-farber.org/cellular-therapies-program/car-t-cell-therapy/car-t-cell-therapy-for-multiple-myeloma/

https://www.mayoclinic.org/diseases-conditions/multiple-myeloma/symptoms-causes/syc-20353378

https://stemcellthailand.org/oncology/multiple-myeloma-treatment/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439649/

https://www.mdanderson.org/cancerwise/car-t-cell-therapy-puts-smoldering-and-multiple-myeloma-survivor-in-remission.h00-159543690.html

Links to Previous Shows

1. Cancer immunotherapy: from T cell basics 
2. Next generation of cancer treatments
3. Advanced liver cancer
4. Management of Liver Cancer
5. Biomarker-driven therapies for lung cancer
6. Understanding Carcinogenesis
7. Prostate Cancer
8. Pancreatic Cancer

In this episode of Facing the Cancer Revolution Podcast we discuss pancreatic cancer to stop prostate cancers and exocrine cancers. We discuss breakthough research, improvements in available treatments.

Pancreatic cancer is frequently diagnosed at an advanced stage, which makes it difficult to treat. It remains relatively rare (about 3% of cancers), but one of the most feared. When possible, pancreatic cancer is treated with surgical measures combined with stem cells and chemotherapy treatment. Non-operable cancers are treated with chemotherapy, possibly supplemented by immunotherapy.

Because they remain symptomless for a long time, pancreatic cancers are diagnosed at a late stage in 80 to 90% of cases. Their treatment is therefore often difficult. They remain rare, representing approximately 3% of cancers. In France, between 8 and 10,000 new cases of pancreatic cancer are diagnosed each year, causing about as many deaths. Pancreatic cancer is slightly more common in men. The average age at diagnosis is 75 years in men and 80 years in women.

In 90% of cases, pancreatic cancer develops from cells that line the ducts leading pancreatic juice to the intestine (see box): this is ductal adenocarcinoma of the pancreas. Most often (70 to 80% of cases), this cancer is born in the part of the pancreas which is close to the small intestine (the "head" of the pancreas).

Resources Discussed in Podcast

• https://www.nhs.uk/conditions/pancreatic-cancer/
• https://www.cancer.gov/types/pancreatic/patient/pancreatic-treatment-pdq
• https://pancan.org/facing-pancreatic-cancer/about-pancreatic-cancer/what-is-pancreatic-cancer/
• https://stemcellthailand.org/oncology/pancreas-cancer-treatment/
• https://www.hopkinsmedicine.org/health/conditions-and-diseases/pancreatic-cancer/immunotherapy-a-new-frontier-for-pancreatic-cancer

Links to Previous Shows

1. Cancer immunotherapy: from T cell basics 
2. Next generation of cancer treatments
3. Advanced liver cancer
4. Management of Liver Cancer
5. Biomarker-driven therapies for lung cancer
6. Understanding Carcinogenesis
7. Prostate Cancer

In this episode of Facing the Cancer Revolution Podcast we discuss prostate cancer to stop prostate cancers reputation of being a killer. We discuss groundbreaking research, drive improvements in treatments, and fight injustice in pallative care.

Traditional treatments for prostate cancer has many side effects. The most common ones are diarrhea, leaking stool, blood in urine, and burning when you pee. It can also cause problems with erection. But, most of these symptoms will go away after the treatment is finished. This treatment can help treat prostate cancer. Read on to learn more about prostate cancer side effects. It can help you decide if the treatment is right for you. It can also save your life.

A doctor will grade prostate cancer according to the Gleason score. The Gleason score is based on the appearance of cells, and a lower score indicates a less aggressive cancer. The Gleason score is the first step in deciding if you have prostate cancer. The Gleason grade is given to each patient based on the grade of cancer cells present in the cancer. The lowest grade is grade one, while the highest grade is grade five. A Gleason score of six represents a low-grade cancer, while a Gleason score of seven or eight indicates a moderate or high-grade cancer.

The Gleason score can be very helpful in determining whether or not you have prostate cancer. If you have a high-grade tumor on a needle biopsy, it will be included in your Gleason score. 

Resources Discussed in Podcast

• https://www.mayoclinic.org/diseases-conditions/prostate-cancer/symptoms-causes/syc-20353087
• https://www.nhs.uk/conditions/prostate-cancer/
• https://www.hopkinsmedicine.org/health/conditions-and-diseases/prostate-cancer/immunotherapy-for-prostate-cancer
• https://stemcellthailand.org/oncology/prostate-cancer-immunotherapy/
• https://www.cancerresearch.org/en-us/immunotherapy/cancer-types/prostate-cancer

Links to Previous Shows

1. Cancer immunotherapy: from T cell basics 
2. Next generation of cancer treatments
3. Advanced liver cancer
4. Management of Liver Cancer
5. Biomarker-driven therapies for lung cancer
6. Understanding Carcinogenesis