In this episode of Lab Rats to Unicorns, John Flavin sits down with Dr. Andrew Pelling—trailblazing biophysicist, artist-trained scientist, and Co-Founder & Chief Scientific Officer of Spiderwort Biotechnologies. Andrew is best known for reimagining living systems, most famously by using decellularized apples and other plants as scaffolds to grow human tissue—work that helped spark an entirely new category of plant-derived biomaterials.

Formerly a professor at the University of Ottawa, Andrew founded the Pelling Lab for Augmented Biology, an unconventional research environment where scientists and artists explored how physical forces—rather than genetic manipulation—shape cellular behavior. His approach focuses on stretching, compressing, and reshaping cells to unlock new biological possibilities.

Andrew shares how his background in the arts shaped his scientific intuition, why curiosity-driven research led from grocery-store experiments to restoring movement in paralyzed rats, and how that breakthrough ultimately inspired the founding of Spiderwort. Along the way, he reflects on failure, leadership, and building imaginative teams—offering a compelling vision for how augmented biology could transform regenerative medicine and human health.