A forgotten epidemic turned people into “living statues,” and one composite patient—Leonard—shows what it means to be awake, alive, and trapped. We trace encephalitis lethargica from its eerie rise to its unexplained disappearance, then step into the late 1960s, when Dr. Oliver Sacks reached for a radical idea: use L‑Dopa, the new Parkinson’s drug, to unlock minds stilled for decades. Leonard opens his eyes, speaks, walks, and even plays piano. Joy floods the ward. Then the pendulum swings—tics, dyskinesias, manic euphoria, crushing lows. The line between treatment and transformation blurs.
We talk through the science and the soul. What does dopamine actually give back, and what does it take when it floods the system? How do you return to a world that raced thirty years ahead without you? Consent gets complicated when communication is reduced to microscript, and “miracle cure” becomes a moving target. Sacks’ enduring lesson isn’t just pharmacology; it’s presence. He listened for hours, asked better questions, and stood by patients before, during, and after the trial. Even when the awakenings faded, dignity stayed.
If you love thoughtful medical history, neurological mysteries, and the ethics behind “miracle drugs,” this story will stick with you. We mix heart, humor, and clear language to unpack sleepy sickness, L‑Dopa side effects, Parkinsonian symptoms, patient autonomy, and the weight of hope. Come for the science; stay for the humanity—and decide for yourself: would you choose a brief return to life, risk and all?
Enjoy the episode? Follow, share with a friend, and leave a quick review so more curious minds can find the show. Your take: miracle, mistake, or something in between?
Sacks, Oliver. Awakenings. New York: Dutton, 1973. (Case history of Leonard L. and other post-encephalitic patients)pmc.ncbi.nlm.nih.govthenewatlantis.comnewyorker.com
Charlotte Allan. “Awakenings.” BMJ, vol. 334, no. 7604, 2007, p. 1169. (Medical classic review of Sacks’s book)pmc.ncbi.nlm.nih.govpmc.ncbi.nlm.nih.gov
Jacobs, Alan. “A Humanism of the Abyss.” The New Atlantis, Fall 2025. (Discussion of Sacks’s approach and Leonard’s communications)thenewatlantis.comthenewatlantis.com
Aviv, Rachel. “Oliver Sacks Put Himself Into His Case Studies. What Was the Cost?” The New Yorker, 15 Dec 2025. (Biographical article with quotes from Awakenings and Sacks’s notes)newyorker.comnewyorker.com
LeWitt, Peter. “A Half-century of Awakenings.” Neurology, vol. 101, no. 13, 2023, pp. 582–584. (50-year retrospective on Sacks’s Awakenings)pmc.ncbi.nlm.nih.govpmc.ncbi.nlm.nih.gov
Oliver Sacks Foundation – Awakenings book page (accessed 2026). (Background on the book and Sacks’s reflections)oliversacks.comoliversacks.com
Awakenings (dir. Penny Marshall, 1990) – Film based on Sacks’s book (for contextual understanding of Leonard’s portrayal)en.wikipedia.orgen.wikipedia.org
Send us a text
Support the show
This website contains affiliate links. This means that if you click on a link and purchase a product, I may receive a small commission at no extra cost to you. This helps support the running of this website and allows me to continue providing valuable content. Please note that I only recommend products and services that I believe in and have personally used or researched.