I didn’t see that coming cover art

I didn’t see that coming

I didn’t see that coming

Written by: Brendan Bouffler
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New po this is a podcast for people interested in or suffering from optic neuritis and associated illnesses - but from a patient's prospect. When I started my journey with optic neuritis, there were very few resources on the Internet that could describe to me what I could expect both from the disease and the treatment and how it would feel. So this podcast is designed to fill that app.

I'm helped in each episode by my friend and collaborator Dr. Joanna Gould, who has a PhD neurology and helps explain some of the more difficult scientific topics.

They certainly isn't medical advice, but it's a medical experience that hopefully you can benefit from.

Contact us at boof@sighup.net.

Copyright 2026 All rights reserved. Hygiene & Healthy Living Physical Illness & Disease
Episodes
  • Promiscuous, sheep, and more about monoclonal antibodies

    Promiscuous, sheep, and more about monoclonal antibodies
    May 22 2026

    Brendan, Joanna, and immunologist Dr. Paul Ibbett continue their deep dive into biologics, the immune system, and Brendan's treatment journey.

    What's covered

    • Demyelination explained — and why Brendan's optic-nerve-only damage points away from MS
    • How the brain and immune system talk to each other (featuring a spawning salmon and a very over-enthusiastic ram)
    • A new vagus-nerve implant that acts like a "snooze button" on TNF-alpha
    • Why biologics cost so much — manufacturing in giant bioreactors, ~$1bn per approved drug, and the NHS vs. private cost question (Brendan paid £3,000 per Rituximab infusion privately)
    • Bispecific antibodies — the next frontier, especially in cancer
    • The future: sequencing patient immune systems and using AI/ML to pick the right drug
    • Could biologics ever be injected directly into the CSF? Possibly, but not without certainty about the target
    Show More Show Less
    26 mins
  • The time I just said no

    The time I just said no
    May 8 2026

    Last week we covered a lot of exotic tests and the exotic tests list continue. But there was also a time when I just flat out said no to a test because I thought it was silly. And the logic behind it was silly too.
    Show More Show Less
    31 mins
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