SP-CERN: Exploring the Spectrum of Movement Disorders in Early-Onset Hereditary Spastic Paraplegia
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SP-CERN: Exploring the Spectrum of Movement Disorders in Early-Onset Hereditary Spastic Paraplegia
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New research from the Spastic Paraplegia Centers of Excellence Research Network (SP-CERN), a research group of the Rare Diseases Clinical Research Network.
Exploring the Spectrum of Movement Disorders in Early-Onset Hereditary Spastic Paraplegia.
This summary is based on a paper published in the journal Movement Disorders on December 2, 2025.
Hereditary spastic paraplegia (HSP) is a large group of inherited disorders that affect nerves that send messages to the muscles. Individuals with early-onset HSP can experience movement disorders, but not much is known about why and how often they occur.
In this study, researchers explored the spectrum of movement disorders in early-onset HSP. The team analyzed data from 428 children and young adults with HSP, reviewing clinical characteristics and video examinations.
Results showed that movement disorders—including dystonia, parkinsonism, and ataxia—were common in childhood-onset HSP. Authors note that routine screening and management tailored to specific genotypes of movement disorders—especially dystonia—may improve functional outcomes and quality of life.
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