In this episode, Kayla Girgen, RD, CPT, offers a balanced, honest breakdown of the nutritional risks, metabolic trade-offs, and real-world benefits of GLP-1 receptor agonist medications.

These drugs are powerful tools, but they also come with side effects, financial commitment, and lesser-discussed concerns—like changes in motivation, mood, and enjoyment of food. You’ll learn:

• How GLP-1 receptor agonists work
• The difference between semaglutide and tirzepatide
• The most common and overlooked side effects
• Why muscle loss is one of the biggest risks—and how to prevent it
• What “anhedonia” is and why it matters
• What happens when you stop taking a GLP-1 medication
• The financial and physiological realities of long-term use
• The critical role of strength training and nutrition while on these drugs

If you’re currently taking a GLP-1 medication, considering one, or simply curious about the hype, this episode will help you think critically and protect your future health.

Chapters:

00:00 Introduction to the Complexities and Considerations of GLP-1 Medications
09:33 Active Ingredients, Brand Names & Terminology for GLP-1 Medications
13:52 Incretin Effect of GLP-1 and GIP
18:01 GLP-1 Injectables, Pills, and Compounding Pharmacies
20:20 Cardiometabolic Benefits of GLP-1 Agonist Medications
24:08 Warning About Oral Birth Control and GLP-1 Cessation Before Medical Procedures
29:09 Benefits of GLP-1 Agonist Medications
32:23 Side Effects of Semaglutide and Tirzepatide
38:08 Muscle Loss and How To Minimize It
46:49 "Anhedonia": A Less-Known Side Effect of GLP-1RAs
51:46 Sustainability, Cost, and Weight Regain
55:49 Closing Thoughts and Considerations

Keywords:
Side effects of GLP-1 weight loss medications, Mounjaro vs Ozempic, GLP-1 receptor agonists explained, semaglutide vs tirzipatide, muscle loss on GLP-1 medications, long-term effects of GLP-1 meds, how to prevent weight regain after Ozempic

🔗Links Mentioned In This Episode:

Blog Post: GLP-1 Diet Plan: How to Lose Weight Without Losing Muscle

Shop Cure Electrolytes
*Use KAYLA for 20% off

Join the Sugar & Strength Academy
*Try for FREE! Your first week is on me.

Apply to Work with Kayla

Submit Your AMA Question(s)

More from Kayla:

Ruck Fit: Build Strength and Endurance by Walking with Weight

Free Dietitian-Approved Food List

Download Kayla’s Free CGM Guide

Follow on Instagram

Subscribe on YouTube

Kayla's Website