Name Bias Delays STEMI Diagnosis 02/24/26

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Name Bias Delays STEMI Diagnosis 02/24/26

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Welcome to Cardiology Today – Recorded February 24, 2026. This episode summarizes 5 key cardiology studies on topics like Healthcare disparities and Heart failure. Key takeaway: Name Bias Delays STEMI Diagnosis. Article Links: Article 1: Benefit of early initiation of disease-modifying therapy in community-based patients with suspected heart failure. (European heart journal) Article 2: Aortic Insufficiency Progression in Patients with Left Ventricular Assist Devices and Prior Impella Support. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Longitudinal Trends and Contemporary Outcomes of Combined Heart-Lung Transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Identification of a Highly Functional Effector CD8+ T Cell Program after Transplantation in Mice and Humans. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 5: Impact of name-based implicit bias on time to diagnosis and outcomes in ST-elevation myocardial infarction. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/name-bias-delays-stemi-diagnosis-02-24-26/ Featured Articles Article 1: Benefit of early initiation of disease-modifying therapy in community-based patients with suspected heart failure. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40879671 Summary: The study concluded that initiating heart failure therapies when an elevated N-terminal pro-B-type natriuretic peptide level is detected in community-based patients with suspected heart failure may reduce the risk of early adverse outcomes. The analysis suggested a potential benefit from the early initiation of a sodium-glucose cotransporter two inhibitor and/or a mineralocorticoid receptor antagonist in these patients. This therapeutic approach applies to individuals with suspected heart failure who also have pre-existing non-heart failure related indications. The findings underscore the importance of prompt pharmacological intervention in managing early stages of heart failure. Article 2: Aortic Insufficiency Progression in Patients with Left Ventricular Assist Devices and Prior Impella Support. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41730484 Summary: The study addressed a critical clinical concern regarding the incidence and risk factors for aortic insufficiency in patients receiving mechanical circulatory support. It focused on individuals who received Impella percutaneous temporary left ventricular assist devices, those with Impella followed by durable left ventricular assist devices, and those with durable left ventricular assist devices alone. Understanding aortic insufficiency progression is crucial for managing patients supported by these devices, as its incidence and specific risk factors have remained unclear in this population. This research highlighted the need for clarity regarding distinct clinical pathways and outcomes in these complex patient groups. Article 3: Longitudinal Trends and Contemporary Outcomes of Combined Heart-Lung Transplantation. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41730483 Summary: The study found that combined heart-lung transplants in the United States experienced a gradual decline, but then showed a significant rise in procedures since 2014, particularly among adults. This shift represents an important change in the landscape of thoracic organ transplantation. Understanding these evolving longitudinal trends is critical for clinicians managing patients awaiting or undergoing this complex procedure. The research provides key insights into the contemporary patterns of combined heart-lung transplantation. Article 4: Identification of a Highly Functional Effector CD8+ T Cell Program after Transplantation in Mice and Humans. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41730451 Summary: The study identified a highly functional effector C.D.8 positive T cell program crucial for post-transplantation immune responses in both mice and humans. Researchers found that agonism of the C.D.43 1B11 receptor in vitro induced C.D.8 positive T cell proliferation even with sub-threshold antigen stimulation. In vivo, C.D.43 1B11 agonism successfully overcame costimulation-blockade induced tolerance and significantly enhanced C.D.8 positive T cell cytokine ...

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