Get ready for a flavorful kickoff to 2026 with the latest Note to File podcast! 🎙️

In this episode, Denali and Brad serve up laughter and insight—from opening with comedic banter and cheese puns (did you know it's National Cheese Lovers Day?) to swapping stories about their favorite cheeses and regional cheese culture. But that's just the appetizer! Dive into the latest trends from the JPM conference, including industry updates, M&A highlights (or the lack thereof), and debates on the real significance of company announcements in clinical research. The hosts weigh in on the rising role of AI—like Anthropic's Claude—in trial design, recruiting, and regulatory submissions, and raise thought-provoking questions about using AI with imperfect clinical data.

The discussion gets real as they tackle the ethics of government-funded vaccine studies and the challenges of conducting clinical research in vulnerable populations. Plus, stick around for info on upcoming conferences, meetups, and the possibility of a live podcast stream from SCOPE!

Whether you're a cheese connoisseur or a clinical trials pro, this episode has something for everyone. Don't forget to like, comment, and subscribe for more unfiltered coverage of the world of clinical research!

Denali and Brad welcome Dr. Les Enterline, a seasoned physician assistant and industry leader, to discuss the evolving landscape of CRO models—Full Service Outsourcing (FSO) vs. Functional Service Partnerships (FSP)—and their impact on sponsors, sites, and patients.

Discover: • Dr. Enterline's compelling career journey from clinical practice to industry leadership • The inner workings and real-world differences between full service and FSP models • How sponsors choose their approach—and what it means for site operations and staff retention • The vital role of partnership, communication, and empathy in successful research collaborations • Practical insights into how AI and technology are transforming clinical trial efficiency

Whether you're a research professional, sponsor, or just curious about how groundbreaking therapies move from concept to clinic, this episode will equip you with valuable knowledge and perspective.

In this New Year's special, we kick things off with gym woes, bacon vs. sausage debates, and a little dose of existential career crisis. Then it's on to the real meat: wild AI spin-outs, the hard truths about commercializing tech in trials, AstraZeneca's eye-opening drug recall, and bold (plus slightly pessimistic) predictions for 2026. A

re rising healthcare costs going to split trial participation? Is the AI revolution real or just LinkedIn hype? And can New Year's resolutions actually stick in our industry? Join us for candid industry takes, unscripted nonsense, and a sprinkle of optimism (maybe). Don't forget to comment with your resolutions, predictions—or just your favorite breakfast meat!