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Multiple Myeloma Advances: Dr. Adeel Khan on New Treatments, CAR-T, and AI in Research

Season eight of Villages Vitality Life: Senior Life Unscripted features host Mike Roth interviewing Dr. Adeel Khan, a hematologist-oncologist and epidemiologist at UT Southwestern and director of myeloma epidemiology research and a monoclonal gammopathy precursor clinic. Khan explains multiple myeloma as a plasma cell cancer common in older adults (median onset 69) and notes rising prevalence as patients live longer, with median survival improving from about three years in the 1990s to over nine to ten years today. He outlines treatment evolution from older chemotherapies to targeted drugs and newer immunotherapies, including CAR-T (ide-cel and cilta-cel), citing 2025 ASCO data suggesting some long-term remissions that may be curative. They discuss AI analyzing genomic data, unclear prevention and risk patterns, possible benefits of plant-based diets, early MGUS/GLP-1 data, and how to contact UT Southwestern (214-648-3111).

00:00 Season 8 Welcome
00:39 Meet Dr Adeel Khan
01:46 Why Blood Cancers
03:13 What Is Myeloma
05:04 Treatment Breakthroughs
07:25 Immunotherapy And CAR T
10:41 Long Term Remission Stories
11:38 Sponsor Health Tip
13:19 AI And Genetics Research
15:09 Risk Factors And Prevention
17:04 Diet And GLP 1 Questions
18:56 Clinic Contact Info
20:11 Final Thoughts And Sign Off

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Open Forum in The Villages, Florida is Produced & Directed by Mike Roth
A new episode will be released most Fridays at 9 AM
Direct all questions and comments to mike@rothvoice.com

If you know a Villager who should appear on the show, please contact us at: mike@rothvoice.com

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Bill Paddock on Voices, Improv, and Finding Comedy in Retirement at The Villages

Season eight of Villages Vitality Life: Seniors Life Unscripted opens with host Mike Roth interviewing Villages resident Bill Paddock, a retired Bureau of Prisons correctional officer and former Marine who moved from Pennsylvania to The Villages to be near family. Paddock describes how Looney Tunes voice actors (especially Mel Blanc) sparked his interest in character voices and comedy, and how early attempts at standup were derailed after realizing a headliner had recently used similar “different laughs” material, keeping him offstage for nearly 20 years. Though he considers himself introverted, he enjoys performing for unfamiliar audiences and shares a Marine Corps prank story and a radio improv character, “Bobby with an eye,” including a parody Sinatra-style song. Roth explains key improv rules and invites Paddock to local Monday sessions; Paddock plans a voice-driven podcast, Mad Dog Comedy, aiming for release by Christmas.

00:00 Season Eight Kickoff
00:40 Meet Bill Paddock
01:12 Why The Villages
01:33 Cartoons Spark Comedy
02:09 Voices and Improv
04:37 Finding the Funny
05:13 Military to Corrections
06:06 Okinawa Phone Call Win
10:01 First Standup Set Flop
12:40 Alzheimers GLP One Update
14:20 Introvert on Stage
15:51 Improv Rules Basics
16:41 Make Partners Shine
16:54 No Mistakes In Improv
17:24 Why Improv Beats Script
17:41 Show Night Highlights
18:08 Radio Improv Origins
18:56 Bobby With An Eye
19:39 Sinatra Parody Clip
23:11 Prince William Aftermath
24:03 Retirement And Pickleball Pressure
25:16 Villages Club Culture
26:58 Tap Shoes Mixup
27:39 Mad Dog Comedy Podcast
28:49 Closing Thanks And Supporters

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Support the show

Open Forum in The Villages, Florida is Produced & Directed by Mike Roth
A new episode will be released most Fridays at 9 AM
Direct all questions and comments to mike@rothvoice.com

If you know a Villager who should appear on the show, please contact us at: mike@rothvoice.com

Send us FAN MAIL text, include your cell# for a reply

Vitalic Health: Transforming Senior Care with AI Technology

How Vitalic Health Uses AI and Clinicians to Identify and Treat Undiagnosed Depression in Seniors

Season eight of Villages Vitality Life: Senior Life Unscripted introduces a new format featuring leaders and resources relevant to seniors in and around The Villages, Florida. Host Mike Roth interviews Vitalic Health co-founders Ben Gardner and Michelle Hoy about an AI-enabled program that screens Medicare Advantage members for depression and connects those who screen positive to immediate virtual care. Michelle explains that AI voice agents, texting/email, and timing optimization support outreach while preserving patient choice to speak with a human clinician. They discuss CMS requirements for annual depression screening in Medicare Advantage, the impact of undiagnosed depression alongside chronic conditions, barriers and stigma that lead to false negatives, and Vitalic’s “warm handoff” to coaching, therapy, and medication support via telehealth. They also cover suicide-risk screening (PHQ-9), crisis guidance including 988, and how ACOs in traditional Medicare may partner similarly. Contact details for Vitalic Health are provided.

00:00 Season Eight Kickoff
00:37 Meet Vitalic Founders
01:35 How AI Screening Works
03:01 Medicare Screening Mandate
05:00 Beyond Screening to Care
06:10 Why Seniors Avoid Help
07:19 Traditional Medicare and ACOs
10:32 Telehealth Warm Handoff
11:52 Alzheimers Tip Break
12:55 Caller ID and Voicemail
13:43 AI Voice Script and Learning
15:38 Honest Answers and Stigma
16:36 Real Patient Turnaround Story
18:35 What Families Can Do
19:22 Suicide Risk and Intervention
21:53 How to Reach Vitalic
23:59 Final Thoughts and Signoff

New FAN MAIL features TXT & Voice Mial

Support the show

Open Forum in The Villages, Florida is Produced & Directed by Mike Roth
A new episode will be released most Fridays at 9 AM
Direct all questions and comments to mike@rothvoice.com

If you know a Villager who should appear on the show, please contact us at: mike@rothvoice.com