In this episode of the FLASCO OncoPod, host Dr. Edgardo Santos, President of the Florida Society of Clinical Oncology (FLASCO), leads a multidisciplinary discussion on the evolving role of immunohistochemistry (IHC) in precision oncology. Joined by Dr. Lamees Saeed (Tampa General Hospital Cancer Institute), Dr. Jesus Fabregas (Memorial Cancer Institute), Dr. Ana Sandoval (Herbert Wertheim Cancer Institute at Baptist Health South Florida), and Dr. Nathalie McKenzie (AdventHealth Cancer Institute), the panel explores how IHC has evolved from a diagnostic tool into a critical component of biomarker-driven treatment selection.

The conversation highlights how IHC is shaping clinical decision-making across breast, gastrointestinal, gynecologic, and thoracic cancers, with experts discussing reflex testing, tissue stewardship, workflow between pathology and oncology, and the growing importance of predictive biomarkers such as HER2, PD-L1, mismatch repair (MMR), Claudin 18.2, and hormone receptors. Panelists also share practical insights on when IHC provides the greatest clinical value, how testing protocols have adapted alongside emerging therapies, and why strong communication between clinicians and pathologists is essential for delivering timely, personalized cancer care.

This podcast is being sponsored by Daiichi Sankyo.