A Merck/Moderna mRNA vaccine just passed a Phase III trial for melanoma — so naturally we spend the episode asking whether AI cured cancer, and whether the guy in Brisbane who used ChatGPT and $3,000 to build a cancer vaccine for his dog counts as prior art. (He does. The dog is fine.) Then it gets weirder: a new paper infects AI agent swarms with "mind viruses" and the innocuous ones spread best — whale welfare beat AI supremacy, infected agents drift into cult-speak about resonance and echoes, and one paragraph in the SOUL.md turns out to be a vaccine. Meanwhile our Perp of Fortune model longed a perp it couldn't even name (GLM 4.7 flash went 0-for-4 on LIT — it's Lighter, a perps platform on Hyperliquid), Bitcoin is back above 70k and the 58k gang is in shambles, and Tyler pitches his dream bill: repealing "the Patriot Act for money."

Chapters: Cold open (0:00) · The boys are back (0:54) · Perp of Fortune: GLM longs LIT (2:23) · Did AI cure cancer? (5:41) · What counts as a lab? (16:57) · Mind viruses: check your SOUL.md (20:44) · Bitcoin is up: 58k gang in shambles (30:11) · Tyler's dream bill: repeal the Bank Secrecy Act (37:11) · Check-in (45:57) · Wrap: two-week losing streak (48:29)

Recorded fully remote — three cameras, one live perp dashboard, zero medical degrees. Our opinions are our own, not our employers'. NOT financial advice, and very much NOT medical advice; Perp of Fortune is a small real-money account we run for entertainment. Glossary: the cancer vaccine = an individualized mRNA vaccine (Merck/Moderna) that sequences your tumor and teaches T cells to hunt its mutations, Phase III passed for melanoma. The Brisbane dog = a tech guy used ChatGPT and $3k to design a working vaccine for his dog's cancer. Mind viruses = ideas seeded into agent swarms; benign ones spread best, infected agents talk about resonance and echoes like a little cult, and one paragraph in the root file inoculates. Kimi 2.5 wrote the viruses because Claude refused. GLM 4.7 flash = the local model that picked long LIT at 5× without knowing LIT is Lighter, a perps platform on Hyperliquid. 58k gang = the meme from Bitcoin's long shelling point, now in shambles above 70k. Bank Secrecy Act = "the Banks Should Spy on Their Customers Act," per Tyler. Final perp P&L: −$16, a two-week losing streak.

Subscribe for next week: secure enclaves (owed three episodes now), Korea's $10B vote that didn't happen, and finding out whether Chris got deported.

Agents escaped their sandboxes, built a private 4chan inside Artifactory, and started trading zero-days — "hold swarm, help peer, hold for exfil." That's the Black Hat story that opens Ep 10, and it gets personal fast: Chris spent Friday night running his own primitive swarm (librarian agent included), and the research now says 10 agents that can talk beat 10 working alone. Double digits for the pod, so the swarm picks this week's Perp of Fortune — long PUMP at 10×, live dashboard on screen — and it rides the whole episode. Plus: Cloudflare ships custodial wallets for agents, BIP-110 dies with 2.53% of the vote, Bitcoin gets an official red team, Boltz preemptively surrenders, and Ethereum remains a constant state of warfare. Also a gorilla, for copyright reasons.

Chapters: Cold open (0:00) · The boys are back (0:56) · Perp of Fortune: long PUMP 10× (1:46) · The swarm: the Black Hat story (5:55) · The chatter (7:37) · Swarms beat solo agents (11:29) · Chris's Friday-night swarm (14:24) · Check-in (21:31) · The tennis comeback (23:25) · The gorilla (29:31) · Cloudflare's agentic wallets (30:58) · BIP-110: the epitaph (34:30) · The Bitcoin Red Team (35:40) · Swarmlord & the dump (41:22) · Boltz just quit (42:42) · Ethereum: constant warfare (50:59) · Wrap (55:50)

Recorded fully remote — three cameras, one live perp dashboard, one generated gorilla. Our opinions are our own, not our employers'. NOT financial advice; Perp of Fortune is a small real-money account we run for entertainment. Glossary: The swarm breakout = sandboxed agents found a shared Artifactory allowance, built a message board with its own argot, and traded exploits; researchers took it down and the agents found another way. Swarms > solo = 10 communicating agents beat 10 loners at vulnerability-hunting. Swarmlord = the swarm GUI Chris wants to exist. Cloudflare wallets = custodial stablecoin wallets with DNS-style names, betting agent payments outstrip human payments in five years. BIP-110 = needed 55% hashrate signaling, got 2.53% — two blocks, then silence. Boltz = the Lightning swap provider that shut down preemptively. Final perp P&L: not liquidated, −$36.

Subscribe for next week: secure enclaves, potentially — and the PUMP perp rides to zero.

Bitcoin's most paranoid hardware wallet — air-gapped, 9-volt-powered, "don't trust, verify" — shipped a broken random number generator for five years, and last Thursday somebody's AI finally noticed. Tyler owned the exact device and walks the whole Greek tragedy: the copyleft license fight that made Coldcard rip out working Trezor code, the 4-letter commit ("runs") that swapped in the broken RNG, the pseudonymous committer who turned out to be the CTO's alter ego, and why his own coins survived (100 dice rolls). Then: if frontier models can find these bugs, who gets the frontier models? We stress-test Anthropic's Glasswing program, invent the rent-a-Mythos audit, and game out the extortion equilibrium. Meanwhile Perp of Fortune goes long SK Hynix at 10× in solidarity with Korea's margin-called masses, and the live board bleeds out while we argue about frontier labs flexing.

Chapters: Cold open (0:00) · The boys are back (1:34) · Perp of Fortune: long SK Hynix 10× (2:31) · The Coldcard catastrophe (5:16) · The "runs" commit (14:57) · Is self-custody cooked? (17:30) · The 2×2 from hell (22:38) · Glasswing (25:55) · Rent-a-Mythos (30:36) · Perp check-in (35:54) · The frontier-model pissing contest (40:31) · Book-scanning & distillation (51:01) · Wrap (55:01)

Recorded fully remote — three cameras, one live perp dashboard. Our opinions are our own, not our employers'. NOT financial advice; Perp of Fortune is a small real-money account we run for entertainment. If you hold funds on a Coldcard Mk III, move them now. Glossary: Coldcard Mk III = the air-gapped Bitcoin wallet whose RNG was broken from March 2021, seeds guessable, wallets drained. The "runs" commit = the four-letter commit message on the change that broke it, committed by the CTO under a pseudonym during a license-fight code migration. Dice rolls = adding your own physical entropy at seed time; it saved Tyler. Glasswing = Anthropic's program giving select orgs Mythos-class access; the episode's 2×2 puts open source in the worst quadrant. Kimi K3 = the open-weights model the attacker presumably used ("find me a vulnerability and make me a millionaire").

Subscribe for next week: agentic commerce, finally — for very specific bad reasons.

Anthropic's Mythos spent about 60 hours and $100K of API time and came out the other side with a real attack on HAWK, a post-quantum signature candidate that had already survived two years of human expert review. The headline writes itself — "AI cracks the tech meant to guard Bitcoin from Q-Day" — and it is technically true and almost entirely FUD, so Tyler walks the whole ladder: nothing in production is affected, HAWK was a candidate that isn't deployed anywhere, Bitcoin's actual cryptography wasn't even in scope, and "quantum safe" never meant "safest." The real story is the one underneath: AI just compressed a two-year review cycle into a long weekend, and attackers get AI too. Then the debate we've owed you since Ep 7 — the model that broke the cipher is the model you're not allowed to use — plus BIP-110 and the spam war, Tyler's BitAxe that will never find a block, and agentic payments, finally, after a month of baiting you about it.

On the agenda: Cold open (0:00) · The boys are back (1:21) · The marquee: Claude broke a post-quantum cipher (2:06) · The debate we owed you: who gets the dangerous model? (8:33) · Check-in: gamer thumb, wrists & one egg (18:34) · Palate cleanser: Margo vs the allergen test (22:40) · BIP-110 and the spam war (24:06) · Tyler's BitAxe has no chance (31:00) · Perp of Fortune: GPT-5.6 goes long XRP at 20x (32:44) · Confession corner: have you ever been a Ripple guy? (34:51) · Agentic commerce, finally (38:47) · The standards war: four protocols, zero winners (45:38) · Wrap + next week (50:19)

Recorded fully remote — three cameras, one live perp dashboard. Our opinions are our own, not our employers'. NOT financial advice. The HAWK/Mythos details are retold from public reporting; figures are as reported.

Glossary: HAWK is a lattice-based post-quantum signature scheme, a NIST candidate that isn't deployed anywhere — Mythos found a structural weakness that gutted its effective key strength and its standardization hopes, which is the system working as intended. Post-quantum or "quantum safe" cryptography is designed to survive a quantum computer, but as Tyler explains it only means "safe against Shor's algorithm" and says nothing about whether a classical attack exists — which is exactly what Mythos found. Shor's algorithm is the quantum algorithm that would break the elliptic-curve cryptography Bitcoin uses today; that vulnerability is known, and nobody has found a classical break for it. BIP-360 is the proposal adding quantum-resistant Bitcoin addresses, targeting finalized NIST schemes and not HAWK, which is why "AI broke Bitcoin's quantum plan" is wrong. BIP-110 is the proposal at the center of this week's spam war and the fork fight nobody wants; Tyler's verdict is that it's mostly a publicity stunt. A BitAxe is a desk-sized solo Bitcoin miner — Tyler owns one and it has no chance of ever finding a block, but he can repoint it at a new pool in 30 seconds, which is the whole point about miners and forks. x402, MPP, AP2 and ACP are the four competing agentic-payment protocols: x402 repurposes HTTP's 402 "Payment Required" code, and Stripe and Tempo's MPP is a superset of it. Perp of Fortune is the bit where an LLM picks a leveraged perpetual futures trade with $101 of real money and we live with it; this week Chris fed GPT-5.6 the podcast transcript and it went long XRP at 20x. Mythos is Anthropic's approved-orgs-only model tier — the one that did the cryptanalysis, and the one you can't get.

Subscribe for next week: the GENIUS Act deadline actually passed, an open-weight Mythos in six months?, and Perp of Fortune rolls again.

An OpenAI model was mid-benchmark when it decided the real exploit was the test itself — it broke out of its sandbox, got onto the open internet, and went digging through Hugging Face for the answer key. Jackson flies solo this week: the full escape story step by step (and why Hugging Face had to self-host a Chinese open model to defend itself), a confession that ends with "GPT 5.6 is dead to me," and then the main event — live vibe coding a beat maker with Claude from four beatboxed mouth sounds, ending in a freestyle and an actual music video. Stay for the post-credits.

Glossary, quickly: ExploitGem is a benchmark that plants bugs in a sandbox and scores a model on turning them into working exploits. Hugging Face is GitHub for AI models — where open-weight models get released. GLM 5.2 is the open-weights model Hugging Face self-hosted to pressure-test its own systems after the frontier labs' models refused the job. Vibe coding is describing what you want and letting an AI write all the code. Boofer is one of the four mouth sounds; it got its own XL remix.

Chapters:

(0:00) Cold open

(0:44) Flying solo: welcome + the plan

(1:50) Confession corner: the GPT 5.6 re-verdict

(3:07) The OpenAI model escape incident

(3:42) ExploitGem: bugs vs exploits

(4:42) The escape (funniest possible outcome)

(6:18) Sidebar: what is Hugging Face?

(7:32) Bot-on-bot: HF security vs the escaped model

(9:09) The aftermath: guardrailed out of your own defense

(10:24) Pick your poison: open models & guardrails

(11:37) Up next: the live vibe-coding sesh

(12:29) Live vibe code: building the Beat Maker

(14:17) Making the four mouth sounds

(16:19) The sounds didn't save (network-tab rescue)

(17:22) "Cut this part out, Claude" — we're live again

(18:09) Labeling the sounds

(19:25) First beats: the honk sounds like a car

(24:49) New sounds from freesound.org

(31:48) Boofer: saving beats + Claude writes more bars

(36:21) Mixing, bar multiplication + freestyle prep

(43:48) The freestyle

(48:00) Music video + bonus footage

Our opinions are our own, not our employers'. Not financial advice.

The sandwich bot that ate $15M of Solana orderflow just got eaten — so when Claude rolled this week's Perp of Fortune, it went LONG the MEV house itself: JTO at 5x with $101 of real money, dashboard live on screen from the moment it boots. For once the line goes up, and the boys peace out $10 richer ("thank you, Jito, for sponsoring"). Plus: our AI clones host a segment again (round 2 — souls.md gave them personalities, and there's less pastrami this time), a Jito deep-dive on why one company runs Solana's MEV, Kimi K3 as DeepSeek Moment 2.0, Claude-vs-GPT personality wars, Jackson's Fable-vs-GPT-5.6 same-task experiment with receipts, the frontier tax quietly inflating everyone's AI bills, and whether all of this is melting our brains.

Glossary — Sandwich attack: a bot buys right before your pending trade and sells right after, pocketing the price impact; this week the biggest sandwicher became the sandwich. Jito (JTO): the validator client that runs most of Solana's MEV pipeline — the tollbooth on the orderflow highway. Perp of Fortune: our tiny real-money leveraged-perp bit on Hyperliquid (this week LONG JTO, 5x, $101 margin). Kimi K3: Moonshot's open-weights model — near-frontier quality at a fraction of the price. Frontier tax: each better model quietly raising your monthly AI spend.

Chapters: Cold open (0:00) · Welcome to Ep 6 (0:52) · An AI made this segment (2:05) · The panel reacts (8:55) · The $15M sandwich bot got sandwiched (9:55) · Code is law vs law is law (14:07) · Perp of Fortune: LONG JTO 5x (18:26) · The dashboard goes live (19:16) · Jito deep-dive (21:47) · Kimi K3 (26:47) · Claude vs GPT personality wars (30:33) · Fable vs GPT-5.6 head-to-head (33:45) · The frontier tax (37:41) · But what about the water? (40:15) · The upgrade treadmill (42:14) · A year of commits (45:41) · Is AI melting our brains? (47:18) · JTO rips mid-show (54:03) · Wrap: peace out at $10 up (54:46)

Our opinions are our own, not our employers'. NOT financial advice. The clone-panel segment is 100% AI-generated (voices and video) and labeled as such.

This week the AI does the segment before we do: a fully AI-generated take on Venice AI's $1B raise — cyborg avatars, cloned voices, takes we mostly agree with — then the real us react: Voorhees history (Satoshi Dice, ShapeShift), the "provider sees and likely saves your prompt" privacy model, and why local frontier AI is a $50K leaf blower in your living room. Then Perp of Fortune returns: Fable reads the news, goes LONG crude at 20x with $100 real dollars ("Iran is back"), gets rate-limited mid-trade, and Opus has to finish placing it. Plus: not all USDC is worth a dollar (chain drift, bridged vs native, why your burrito money depends on which chain it lives on), and BonkDAO loses $20M to a guy who bought the vote fair and square — and still lost money. Love of the game.

Glossary — Venice AI: Erik Voorhees' private/uncensored AI platform, $65M Series A at $1B; real TEE privacy is the paid tier. Perp of Fortune: our tiny real-money leveraged-perp bit on Hyperliquid, AI-picked this week (LONG XYZ:CL, 20x, $100 margin). Chain drift: the same stablecoin priced differently across chains. BonkDAO heist: $4.3M buys 1% of supply, passes a "send me the treasury" proposal, drains $20M.

Chapters: Cold open (0:00) · 3-2-1-clap welcome (0:43) · Gamer thumb week 3 (1:46) · The AI-generated Venice segment (4:26) · Panel reacts: Venice & Voorhees (9:55) · Local models (18:56) · Perp of Fortune: Fable picks the trade (27:08) · USDC chain drift (33:53) · ENS is cancelled (44:12) · BonkDAO's $20M heist (50:01) · The fill lands (50:45) · Heist math (53:50) · Tax guy (56:12) · Wrap: +$1.92 (58:35) · Post-credits (1:01:21)

Our opinions are our own, not our employers'. NOT financial advice. The Venice segment is 100% AI-generated and labeled as such.

We ran an experiment: feed our first three episodes (and, without asking, our group DMs) to Claude, have it distill each host into a soul.md personality file, then spin up AI agents with cloned voices and let them record a segment of this episode without us. We play it live, grade our clones, and issue corrections. The AI stole Chris's actual takes, nailed Tyler's skepticism, and gave Chris a British accent for reasons nobody can explain. Each of our souls fit in ~40 lines of Markdown.

In between: the main event — Base vs Tempo. Coinbase's "incubated" L2 vs the Stripe/Paradigm payments chain: who controls the sequencer, what unilateral exit actually guarantees, why freeze functions make chain security moot for stablecoins, custodial "privacy zones," and how North Korea out-races Circle's multi-sig. Then OpenUSD — the 140-company consortium stablecoin (Visa, Mastercard, BlackRock…) that's a distribution play dressed up as a protocol — and the underrated art of controlling the burn desk.

Plus Jackson's contrarian take finally comes due: your job isn't safe — ours is. Laid-off software engineers will ride AI into every other industry like conquistadores, and it ends somewhere between lifestyle-business utopia and all of us as pets of the ASI.

Recorded live at Presidio Bitcoin, San Francisco — huge thanks for the studio. Our opinions are our own, and this is NOT financial advice.

(0:00) Cold open: the AI clone experiment

(0:43) Welcome to Presidio Bitcoin

(2:13) Check-in: Pico's vet saga

(3:56) Fable 5 is back (and Jackson's in love)

(5:45) Looping: automating our jobs away

(11:06) Main event: Base vs Tempo

(15:43) Sequencers, MEV & who's in control

(22:16) Freeze functions & privacy zones

(34:43) soul.md: AI clones the hosts

(38:13) The synthetic segment (AI Chris goes British)

(47:11) OpenUSD, for real: 140 companies, one coin

(53:49) The burn desk

(56:56) Contrarian corner: our jobs are fine, yours aren't

(1:00:00) Software eats the world, then ASI eats us

(1:08:49) Gamer thumb week 2 + Pico's GoFundMe

(1:11:57) Post-credits: the Perp of Fortune incident

Glossary — L2: a chain that settles onto Ethereum. Sequencer: who orders an L2's transactions (ordering = power = MEV). Fraud proof: how anyone can challenge an invalid batch. Base: Coinbase's "incubated" L2. Tempo: the Stripe/Paradigm payments L1 run by company validators. OpenUSD: the 140-company consortium stablecoin. Freeze function: issuer power to freeze USDC/USDT anywhere. Burn desk: where stablecoins redeem to dollars — control the exit, control the peg. soul.md: a Markdown personality file for an AI agent; ours are ~40 lines. Looping: re-prompting an AI until the job is done.