Prolonged QT Elevates Recurrent Stroke Risk by 73% 02/21/26

Failed to add items

Sorry, we are unable to add the item because your shopping basket is already at capacity.

Add to cart failed.

Please try again later

Add to wishlist failed.

Please try again later

Remove from wishlist failed.

Please try again later

Follow podcast failed

Unfollow podcast failed

Prolonged QT Elevates Recurrent Stroke Risk by 73% 02/21/26

Listen for free

View show details

About this listen

Welcome to Cardiology Today – Recorded February 21, 2026. This episode summarizes 5 key cardiology studies on topics like venoarterial extracorporeal membrane oxygenation and calcific aortic valve disease. Key takeaway: Prolonged QT Elevates Recurrent Stroke Risk by 73%. Article Links: Article 1: HEV-Targeted Antibody-Drug Conjugate Promotes Long-Term Cardiac Allograft Acceptance. (Circulation) Article 2: Aspirin use, lipoprotein(a), and calcific aortic valve disease: the Multi-ethnic Study of Atherosclerosis. (European heart journal) Article 3: Temporal Hemodynamic Patterns in Cardiogenic Shock Treated with Isolated PVAD and Combined Therapy with VA-ECMO. (Journal of cardiac failure) Article 4: Prolonged QT interval and risk of recurrent stroke in the Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke (ARCADIA) trial. (Heart (British Cardiac Society)) Article 5: Predictors of Stroke Volume Improvement with AV-Optimised Conduction System Pacing in Patients with AV Dromotropathy. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/prolonged-qt-elevates-recurrent-stroke-risk-by-73-02-21-26/ Featured Articles Article 1: HEV-Targeted Antibody-Drug Conjugate Promotes Long-Term Cardiac Allograft Acceptance. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41717681 Summary: An antibody-drug conjugate targeting high endothelial venules in lymph nodes has been shown to promote long-term cardiac allograft acceptance. This therapeutic strategy leverages the crucial role of high endothelial venules in mediating naive T cell entry into lymph nodes, a vital step for transplant acceptance under costimulatory blockade. The conjugate specifically targets a glycoprotein containing 6-sulfo sialyl Lewis X on these venules, which forms the binding site for L-selectin on naive T cells. This approach offers a novel mechanism to prevent immune rejection in heart transplant recipients. Article 2: Aspirin use, lipoprotein(a), and calcific aortic valve disease: the Multi-ethnic Study of Atherosclerosis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41721439 Summary: In this observational study of up to 6598 participants, lipoprotein(a) and L. D. L. cholesterol were confirmed as causally linked to aortic valve calcium and aortic stenosis. The analysis found that aspirin use was not associated with incident aortic valve calcium or aortic stenosis. This lack of association held true regardless of baseline lipoprotein(a) or L. D. L. cholesterol levels. The data suggests that aspirin does not mitigate the risk of calcific aortic valve disease in individuals with high lipoprotein(a). Article 3: Temporal Hemodynamic Patterns in Cardiogenic Shock Treated with Isolated PVAD and Combined Therapy with VA-ECMO. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41720453 Summary: This study described the temporal hemodynamic patterns observed in cardiogenic shock patients receiving either an isolated microaxial flow pump or combined therapy with venoarterial extracorporeal membrane oxygenation. Hemodynamic indices were analyzed from pre-device installation, post-installation, and 24 hours after, up to device explantation, using data from the U. N. L. O. A. D. E. R. S.-P. VAD Registry. The study characterized these hemodynamic trends for both treatment groups. Hospital survival was also analyzed in relation to these patterns, providing comparative data on mechanical circulatory support strategies in cardiogenic shock. Article 4: Prolonged QT interval and risk of recurrent stroke in the Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke (ARCADIA) trial. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41720625 Summary: A secondary analysis of the A. R. C. A. D. I. A. trial found that a prolonged Q. T. interval independently predicted an increased risk of recurrent stroke or systemic embolism in patients with cryptogenic stroke and atrial cardiopathy. This association held true for both the apixaban arm, with a hazard ratio of 1.70 (95 percent confidence interval 1.05-2.75), and the aspirin arm, showing a hazard ratio of 1.76 (95 percent confidence interval 1.05-2.95). The overall adjusted hazard ratio for this risk was 1.73 (95 percent confidence interval 1.25-2.38), with no significant interaction between Q. T. interval prolongation and treatment assignment (P value 0.95). This data demonstrates that prolonged Q. T. interval is an independent predictor of recurrent stroke regardless of antithrombotic treatment. Article 5: Predictors of Stroke Volume Improvement with AV-Optimised Conduction System Pacing in Patients with AV Dromotropathy. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41711207 Summary: This study identified electrocardiographic and echocardiographic predictors of acute stroke volume improvement ...

No reviews yet