In this episode, Mary and Sharisse discuss stories from past workplaces (including a children's hospital, a TV station, and a restaurant where a violent assault took place), reconciling day jobs with artistic aspirations (especially when they're the wrong kind of environment for an artist to be in), what we can learn from human suffering, and what it means to be successful. Sharisse has a special message for an old grad school nemesis and former hospital colleagues. We also learn why parents who work in clinical research should never do Career Day at school.

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In this episode, Mary and Sharisse discuss connecting generations through music (including fun concert stories), the healing power of art, and truth being stranger than fiction (or shock value!). There may or may not also be an impression of Elmo singing The Strokes.

In this episode (which is a bit of a departure from the normal format), Mary, Sharisse, and their friend Stephanie tell stories of old, crazy roommates from their younger days.

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In the first episode, Mary and Sharisse talk about their shared experience with CVS (Cyclical Vomiting Syndrome) and talk a bit about Sharisse's film about it, "Nothing Solid".