We welcome back Dr. Jake Deutsch, founder and director of Oakwood Precision Medicine and our go-to longevity expert, to break down what peptides actually are, how they work, and where science ends, and speculation begins.

Peptides and regenerative medicine are reshaping how we think about health, aging, aesthetics, and longevity, but as this space rapidly evolves, it is also filled with hype, confusion, and real risks when used without proper understanding or oversight.

Together, we discuss:
• What peptides are and how they are regulated
• The role of GLP-1 peptides in weight loss, metabolic health, and longevity
• The difference between strategic use and misuse, including concerns around muscle loss, bone health, and so-called “Ozempic face”
• The most talked-about peptides in longevity and aesthetics and how they are administered
• The risks of stacking and cycling and what proper monitoring should really look like
• Why the conversation is shifting from lifespan alone to vitality, quality of life, and optimized aging
• How beauty from the inside out is changing aesthetic medicine, from lifestyle and supplements to advanced regenerative tools

This is a grounded, science-forward conversation about using powerful tools responsibly, safely, and with intention for long-term health.

🎧 Listen now and rethink what pro-aging really means.

For more from me on pro-aging, check out my book, The Pro-Aging Playbook.

𝐅𝐨𝐥𝐥𝐨𝐰 𝐦𝐞 𝐨𝐧 𝐚𝐥𝐥 𝐬𝐨𝐜𝐢𝐚𝐥 𝐩𝐥𝐚𝐭𝐟𝐨𝐫𝐦𝐬 𝐟𝐨𝐫 𝐦𝐨𝐫𝐞:
Instagram: https://www.instagram.com/drpauljarrodfrank/
Facebook: https://www.facebook.com/drpauljarrodfrank
TikTok: https://www.tiktok.com/@drpauljarrodfrank?
YouTube: https://www.youtube.com/user/pfrankmd
LinkedIn: https://www.linkedin.com/company/pfrankmd/

We’re wrapping up the season with a special solo episode.

In this final episode, I break down the biggest shifts in aesthetic medicine in 2025 and what I believe is coming next in 2026, from injectable awakenings to surgical hype and the rise of regenerative medicine.

𝐖𝐞 𝐝𝐢𝐯𝐞 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐦𝐨𝐬𝐭 𝐭𝐚𝐥𝐤𝐞𝐝-𝐚𝐛𝐨𝐮𝐭 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭𝐬 𝐨𝐟 𝐭𝐡𝐞 𝐲𝐞𝐚𝐫, 𝐢𝐧𝐜𝐥𝐮𝐝𝐢𝐧𝐠:
✨ The rise of “filler fear” and why injectables still have a place when used responsibly
✨ The year of celebrity surgery and the deep plane facelift hype, plus why technique and timing matter
✨ Regenerative medicine and peptides, what’s promising, what’s over-marketed, and what needs more data
✨ Why the next 5 to 10 years will be the decade of maintenance, with lasers, resurfacing, and injectable-sparing technologies
✨ Why fat is poised to be the next major focus, and the resurgence of microfat and nanofat for regenerative results

To close, I share what I’m watching for 2026 and beyond as aesthetics continues moving toward smarter, safer, more natural pro-aging outcomes.

Thank you for listening all year. Your support is what makes this podcast possible. Here’s to a strong finish to 2025 and an even better 2026. 🥂

🎧 Listen to the full episode and catch up on the rest of the season wherever you get your podcasts.

For more on pro-aging, check out my book, The Pro-Aging Playbook.

For more from me on pro-aging, check out my book, The Pro-Aging Playbook.

𝐅𝐨𝐥𝐥𝐨𝐰 𝐦𝐞 𝐨𝐧 𝐚𝐥𝐥 𝐬𝐨𝐜𝐢𝐚𝐥 𝐩𝐥𝐚𝐭𝐟𝐨𝐫𝐦𝐬 𝐟𝐨𝐫 𝐦𝐨𝐫𝐞:
Instagram: https://www.instagram.com/drpauljarrodfrank/
Facebook: https://www.facebook.com/drpauljarrodfrank
TikTok: https://www.tiktok.com/@drpauljarrodfrank?
YouTube: https://www.youtube.com/user/pfrankmd
LinkedIn: https://www.linkedin.com/company/pfrankmd/

𝐒𝟑𝐄𝟗: 𝐘𝐚𝐧𝐠 𝐆𝐚𝐧𝐠 𝐓𝐚𝐤𝐞𝐨𝐯𝐞𝐫
(ft. Dr. Connie Yang)

On this episode, we’re turning the tables. Dr. Paul Jarrod Frank steps into the guest chair as Dr. Connie Yang, Cosmetic Dermatologist at PFRANKMD and his former resident at Mount Sinai, takes over the mic.

From his early days in dermatology to building one of New York’s most recognized aesthetic practices, Dr. Frank shares career-defining moments, advice for young dermatologists, and the philosophy behind PFRANKMD’s evolution into a future of aesthetic and longevity healthcare.

Together, they discuss the importance of mentorship in dermatology, how passion attracts the right people, and the profound trust patients place in medical professionals. They explore how learning what you don’t want to do can be just as valuable as positive experiences, and emphasize the significance of maintaining a patient-centered approach even as a practice grows and evolves.

🎙️ Tune in to hear two generations of dermatology discuss mentorship, innovation, and the future of collaborative care.

For more from me on pro-aging, check out my book, The Pro-Aging Playbook.

𝐅𝐨𝐥𝐥𝐨𝐰 𝐦𝐞 𝐨𝐧 𝐚𝐥𝐥 𝐬𝐨𝐜𝐢𝐚𝐥 𝐩𝐥𝐚𝐭𝐟𝐨𝐫𝐦𝐬 𝐟𝐨𝐫 𝐦𝐨𝐫𝐞:
Instagram: https://www.instagram.com/drpauljarrodfrank/
Facebook: https://www.facebook.com/drpauljarrodfrank
TikTok: https://www.tiktok.com/@drpauljarrodfrank?
YouTube: https://www.youtube.com/user/pfrankmd
LinkedIn: https://www.linkedin.com/company/pfrankmd/