The Lp(a) Paradox Deep Dive
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The Lp(a) Paradox Deep Dive
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About this listen
Join us for a comprehensive exploration of one of cardiometabolic medicine's most puzzling phenomena. This evidence-packed episode synthesizes data from 300,000+ patients, genetic studies, and clinical trials to unravel why insulin resistance drives Lp(a) levels down while driving diabetes risk up. We examine the biological mechanism, analyze drug trial safety signals, and present a new clinical algorithm for interpreting Lp(a) results in metabolic context. Essential listening for clinicians wanting to stay ahead of the paradigm shift in preventive cardiology.
What you'll learn:
• The observational data from massive cohorts
• Genetic evidence establishing causation
• How insulin directly suppresses Lp(a) production
• Clinical trial data on Lp(a)-lowering drugs
• A practical algorithm for patient management
• Why OGTT testing may become crucial