Episodes

  • Jeffrey Guss, M.D. on the Lost History of Psychedelics in Psychoanalysis

    Jeffrey Guss, M.D. on the Lost History of Psychedelics in Psychoanalysis
    Feb 25 2026
    In this episode, Dr. Jeffrey Guss shares his journey in psychedelics starting as a curious 14-year-old during the Summer of Love, to becoming a leading researcher and trainer in psychedelic therapy. We break down the historical relationship between psychoanalysis and psychedelics -- from the 1950's psycholytic therapy with LSD to criminalization in the 1970's through the Controlled Substances Act -- and explore how psychedelic substances can address a myriad of things from mystical spiritual experiences to existential anxiety in cancer patients. The forgotten history of psychedelics in psychoanalysis comes to light through Dr. Jeff's careful attention to the historical record. Episode links: - Dr. Jeffrey Guss, Lead Trainer at Fluence https://www.fluencetraining.com/about/team/dr-jeffrey-guss - Dr. Jeffrey Guss's publications on psycholytic and psychedelic-assisted therapy https://med.nyu.edu/faculty/jeffrey-r-guss
    Show More Show Less
    Less than 1 minute
  • Dr. Alexa Albert on Treating Narcissism with MDMA

    Dr. Alexa Albert on Treating Narcissism with MDMA
    Feb 10 2026

    Dr. Alexa Albert: Treating Narcissism with MDMA

    In the first interview episode of The Psychonaut Show, hosts Dr. John and Dr. Tracy welcome Dr. Alexa Albert. Dr. Alexa’s clinical work focuses on the enduring psychological patterns shaped by early relational trauma, particularly pathological narcissism. This episode centers on Dr. Alexa’s groundbreaking work leading the first clinical trial to investigate MDMA-assisted psychotherapy for pathological narcissism.

    Dr. Alexa discusses the importance of integrating psychedelic treatment with psychotherapy, and how psychoanalytic therapy is particularly suited to this work. She explains why models that separate medicine from sustained therapeutic relationships risk leaving patients emotionally exposed without adequate support. For individuals with narcissistic defenses, she argues, the therapeutic alliance itself is central. MDMA, in her view, does not replace the work of therapy but enhances it.

    Dr. Alexa addresses common misconceptions about narcissism, reframing it not as excessive self-love but as a condition rooted in profound feelings of unworthiness, invisibility, and unmet relational needs. She describes how narcissistic defenses develop as adaptive responses to unsafe early environments and how MDMA-assisted therapy may help patients access buried vulnerability and foster profound relational openness, experiences that would otherwise take years to reach in conventional psychoanalysis. She weaves together psychoanalysis, trauma theory, and psychedelic science, offering a thoughtful and humane vision for how these medicines might expand the possibilities of deep psychological healing.

    Episode Links:
    - Alexa Albert's website https://www.alexaalbert.com/
    - Information on Dr. Alexa's current pilot study for treating pathological narcissism with MDMA-assisted therapy https://depts.washington.edu/mdma-narcissism/
    - Dr. Alexa's co-authored paper providing the rationale for MDMA-assisted therapy as an appropriate, targeted treatment for pathological narcissism https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1529427/full
    Show More Show Less
    Less than 1 minute
  • Introducing The Psychonaut Show

    Introducing The Psychonaut Show
    Jan 26 2026
    In this inaugural episode, psychoanalysts Dr. Tracy and Dr. John introduce The Psychonaut Show and explore the growing convergence between psychoanalysis and psychedelics. Reflecting on their personal and professional journeys, they trace how curiosity about the unconscious, skepticism shaped by the war on drugs, and evolving research in trauma and mental health led them to this shared space. Through discussion of concepts like the psychonaut as an explorer of mind and soul, the default mode network, mystical experience, safety, “set and setting,” and the role of transference and integration, they highlight how psychedelics and psychoanalysis can deepen one another.
    Show More Show Less
    Less than 1 minute