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The Real World Perspective with Manfred Stapff, MD, PHD

The Real World Perspective with Manfred Stapff, MD, PHD

Written by: Manfred Stapff MD PHD
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Welcome to The Real-World Evidence Perspective, a podcast hosted by Dr. Manfred Stapff—physician, researcher, and trusted voice in evidence-based thinking. In a time when misinformation spreads faster than truth, Dr. Manfred Stapff uses real-world data to help listeners uncover clarity amidst confusion. From healthcare to headlines, each episode explores how real-life evidence can help us make better decisions and see the world more accurately. If you're ready to think deeper and challenge what you've been told—you're in the right place.2025 Science Social Sciences
Episodes
  • How Hormone Replacement Therapy Can Transform Women's Life After Menopause
    Dec 30 2025

    Menopause affects every woman, yet for decades hormone replacement therapy (HRT) carried a shadow of fear. In this episode, Dr. Manfred Stapff breaks down what the science actually shows and why the FDA's renewed stance on HRT marks a turning point for women's health.

    Dr. Manfred cuts through decades of confusion by revisiting the 2002 Women's Health Initiative study that examined older women using outdated hormone formulations. He reveals why those findings never applied to women beginning HRT in their late 40s and 50s and highlights what the evidence actually shows. The risks were minimal, and the relief for symptoms like hot flashes, depression, and night sweats is profound.

    He breaks down real-world measures of risk and benefit with clarity, showing how today's low‑dose, bio‑identical, and transdermal therapies offer a far safer profile while meaningfully improving quality of life.

    Hear how evidence‑based care can reshape life after menopause. Tune in the full episode of How Hormone Replacement Therapy Can Transform Women's Life After Menopause.

    Dr. Manfred Stapff is an entrepreneurial biotech and pharmaceutical expert with deep expertise in real-world evidence and clinical research. As a seasoned leader, he brings decades of experience across all phases of drug development, from opportunity assessment to product launch. His work bridges science and strategy, ensuring medical decisions are grounded in accurate, meaningful data. Dr. Stapff is also an author, committed to promoting evidence-based thinking in medicine. His insights challenge misinformation and advocate for scientific integrity in today's data-driven world.

    Connect with Dr. Manfred Stapff, MD:

    LinkedIn: https://www.linkedin.com/in/manfredstapff/

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    22 mins
  • Strengthening the Mind: Yoga-Based Resilience in the Age of Misinformation
    Dec 9 2025

    A stronger mind is essential in a world overflowing with noise, distortion, and digital pressure. In this episode, Dr. Manfred Stapff sits down with Ishan Shivanand, founder of Yoga of Immortals, to explore how yoga-based resilience can help us think clearly, evaluate truth, and stay grounded.

    Ishan reflects on how life in a monastery and later as a mental health researcher shaped his understanding of truth and perception. He explains how yoga helps calm instinctive reactions, creating the space to question, reflect, and resist emotional manipulation.

    They draw clear parallels between Western science and Eastern philosophy, showing how both rely on critical thinking and honest observation. Ishan reveals the practices like non‑judgmental awareness strengthen clarity in an age of deepfakes, algorithm bias, and digital overwhelm.

    Listen to how science and yoga can strengthen your clarity, calm, and critical thinking. Tune in to the full episode of Strengthening the Mind: Yoga-Based Resilience in the Age of Misinformation.

    Ishan Shivanand is a globally acclaimed yogic scholar and mental health researcher who brings ancient Indian knowledge systems into modern conversations on resilience. Trained for over two decades in rigorous meditative sciences, he developed Yoga of Immortals, an evidence-based program proven to strengthen emotional stability amid today's information overload. His work, grounded in non-invasive and non-pharmaceutical modalities, supports communities facing anxiety, burnout, and misinformation-driven stress. From universities to major health institutions, his protocols help individuals build clarity, focus, and mental strength.

    Connect with Ishan Shivanand:

    Website: https://ishanshivanand.com/

    LinkedIn: https://www.linkedin.com/in/ishanshivanand/

    Facebook: https://www.facebook.com/IshanShivanand/

    Instagram: https://www.instagram.com/ishan.shivanand/

    YouTube: https://www.youtube.com/IshanShivanand

    Grab a copy of Ishan Shivanand's Book, "The Practice of Immortality" here: https://ishanshivanand.com/about-the-book/

    Dr. Manfred Stapff is an entrepreneurial biotech and pharmaceutical expert with deep expertise in real-world evidence and clinical research. As a seasoned leader, he brings decades of experience across all phases of drug development, from opportunity assessment to product launch. His work bridges science and strategy, ensuring medical decisions are grounded in accurate, meaningful data. Dr. Stapff is also an author, committed to promoting evidence-based thinking in medicine. His insights challenge misinformation and advocate for scientific integrity in today's data-driven world.

    Connect with Dr. Manfred Stapff, MD:

    LinkedIn: https://www.linkedin.com/in/manfredstapff/



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    21 mins
  • The Power of Giving Life: Inside the World of Organ and Stem Cell Transplants
    Nov 27 2025

    Giving life is one of the most powerful gifts we can offer. In this episode, Dr. Manfred Stapff brings together remarkable stories of courage, generosity, and science in action. With both donors and recipients at the table, this conversation goes beyond medicine. It captures what it truly means to save and share life.

    Dr. Manfred speaks with stem cell donor Mat McConnon, his friend Kyle Kramer who inspired him to join the bone marrow registry, and Charles Walker, a liver transplant recipient who was given a second chance at life thanks to Kyle Walker's living donation. Together, they share how a single decision to donate can ripple across lives and families.

    Their experiences reveal the emotional, ethical, and scientific dimensions of modern transplantation, from stem cell matching to the body's extraordinary ability to regenerate.

    Tune in now to The Power of Giving Life: Inside the World of Organ and Stem Cell Transplants to hear stories of hope, healing, and humanity.

    Dr. Manfred Stapff is an entrepreneurial biotech and pharmaceutical expert with deep expertise in real-world evidence and clinical research. As a seasoned leader, he brings decades of experience across all phases of drug development, from opportunity assessment to product launch. His work bridges science and strategy, ensuring medical decisions are grounded in accurate, meaningful data. Dr. Stapff is also an author, committed to promoting evidence-based thinking in medicine. His insights challenge misinformation and advocate for scientific integrity in today's data-driven world.

    Connect with Dr. Manfred Stapff, MD:

    LinkedIn: https://www.linkedin.com/in/manfredstapff/

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    34 mins
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