With this year’s iteration of the J.P. Morgan Healthcare Conference in the rearview mirror, the biopharma industry has officially closed the door on 2025 as it heads into what is sure to be another eventful year.

In this week’s episode of "The Top Line," Fierce Pharma's Zoey Becker sits down with Angus Liu and Fierce Biotech's Gabrielle Masson to unpack the key topics and trends that stood out at this year's conference in San Francisco. The conversation offers an early look at the themes and questions that could shape the year ahead.

To learn more about the topics in this episode:

• All the meetings, none of the megadeals: Is JPM's purpose evolving?

• JPM26: What’s in a biopharma? CEO says Teva has the goods

• JPM26: Astellas CEO resists 'rescue BD' as $6B Xtandi patent cliff nears

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As payers focus on long-term outcomes and real-world performance, value matters more than ever. RTI Health Solutions experts discuss how clear evidence storytelling drives access decisions.

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In early 2025, the FDA was rocked by sweeping layoffs and leadership turnover, raising questions about whether the agency could maintain its pace in reviewing new drug applications.

By the end of the year, the approval picture told a more complicated story, with momentum building after a slow start.

This week on "The Top Line," we dig into what the numbers really show, which companies and therapies came out on top, and what the FDA’s performance over the course of 2025 signals for the drug review process going forward.

To learn more about the topics in this episode:

• 2025 drug approvals: Despite FDA tumult and macro uncertainty, biopharma scored with 55 new products
• 2024 drug approvals: Small companies loom large with several key FDA nods
• 2023 drug approvals: After a down year, FDA signs off on a bounty of new meds, including 7 from Pfizer

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