Access the mentioned courses here:

Sleep And Psychiatry:

https://psychscene.co/46d0T09

ADHD and Sleep Dysfunction:

https://psychscene.co/4rrE9Cc

In this episode, Dr Sanil Rege explores the "how and why" of sleep by analysing a 2025 Neuron perspective paper (https://pubmed.ncbi.nlm.nih.gov/40961940/) detailing the interplay between sleep, motor circuits, and catecholamine biology.

The discussion unpacks the motor theory of sleep, in which sleep control is embedded within somatic and autonomic motor circuits, and the catecholamine hypothesis, which posits that a core biological function of sleep is the inactivation of dopamine, noradrenaline, and adrenaline.

This podcast provides clinicians with a neuroscientific framework for understanding sleep as an active state transition involving a global downshift of somatic and autonomic motor systems.

#Sleep #Neuropsychiatry #Insomnia

Access mentioned course here: https://psychscene.co/46iAaiI

In this episode, Consultant Psychiatrist, Dr Sanil Rege examines the complex relationship between ADHD pharmacotherapy and the emergence of psychotic symptoms.

By analysing synthesis data from The Lancet Psychiatry (https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(25)00248-2/abstract), the podcast distinguishes between drug-induced events and baseline neurobiological vulnerabilities inherent in ADHD populations.

This podcast provides clinicians with a neuroscientific framework for differentiating between protopathic bias and true medication-induced psychotic phenomena, as well as a step-wise screening pathway for risk-guided prescribing using validated at-risk mental state (ARMS) triage tools.

To get access to the complete podcast catalog and material like this plus over 150 hours of interactive CPD education on psychiatry, check out The Academy using the link below:

https://psychscene.co/45M67jh

Access mentioned courses here:

Clinical Audit On Cognitive Aspects of Depression:

https://psychscene.co/3Z2EdvH

The Aggregation of Marginal Gains as a Philosophy of Clinical Care with Prof Michael Berk:

https://psychscene.co/4rqS62V

In this episode, Dr Sanil Rege examines the KARMA-Dep 2 trial, a randomised controlled trial comparing adjunctive serial ketamine infusions to midazolam for patients with Treatment-Resistant Depression (TRD) in an inpatient setting.

Based on a JAMA Psychiatry article titled “Serial Ketamine Infusions as Adjunctive Therapy to Inpatient Care for Depression,” the discussion explores why statistically insignificant differences between ketamine and psychoactive comparators necessitate a shift in how clinicians evaluate rapid-acting antidepressants, detailing the "wow effect" of early symptomatic drops and the subsequent plateauing of recovery curves.

This podcast provides clinicians with a clinical framework for differentiating between acute symptomatic response and long-term functional recovery in TRD.

Chapters:

00:22 - The KARMA-Dep 2 Trial Headlines
03:44 - Primary Outcomes: Ketamine vs. Midazolam Results
04:26 - Analysing the Curves: The "Wow Effect" vs. Sustained Recovery
08:50 - Neurobiology of Response vs. Neurobiology of Recovery
09:21 - Why Improvement Stalls: The Role of Neuroadaptation
10:47 - Clinical Implications for Inpatient Care

To get access to more materials like this plus over 150 hours of interactive CPD education on psychiatry, check out The Academy using the link below:

https://psychscene.co/4rl6pFV