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This Week in Startups

This Week in Startups

Written by: Jason Calacanis
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 Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.Jason Calacanis
Episodes
  • Why You’ll Choose an AI Doctor (feat. Fred Almeida and Max Weiss) | E2239

    Why You’ll Choose an AI Doctor (feat. Fred Almeida and Max Weiss) | E2239
    Jan 24 2026
    This Week In Startups is made possible by:Sentry.io - sentry.io/twistHubspot - clickhubspot.com/twist2Northwest Registered Agent - https://northwestregisteredagent.com/twistToday’s show:One day soon, you might consult an AI general practitioner about your health, and then the computer will recommend human specialists to take up your case.On TWiST Tokyo, Jason chats with Fred Almeida — founder and CEO of American Medical Intelligence Inc. — and Maxwell Weiss, a partner at Pacific Bays Capital.Together, they discuss the future of medicine, and the opportunities for individuals to take greater control over their health and preventative care strategies.PLUS a look at how Japan has stayed at the forefront of technology despite NOT being a manufacturing hub, why so many Americans are willing to take a pay cut to move to Japan for work, and the concept of “genten shugi,” and how it prevents some Japanese people from communicating with English speakers, despite understanding the language.THEN we hear pitches from some of our favorite Founder University x Japan companies, and Fred, Jason, and Max pick their favorites!Timestamps:(00:00) Introducing today’s big guests: founder Fred Almeida and investor Max Weiss!(5:43) Why Fred thinks one day soon, an AI will be your general practitioner(8:26) The power of getting self-directed medical diagnostics(13:27) Max says Japan has moved into Decade 2 in its venture capital journey(14:37) Sentry - New users can get $240 in free credits when they go to sentry.io/twist and use the code TWIST(16:05) Max and Jason had wagyu barbecue the other night(17:10) Japan doesn’t OFFICIALLY have a standing army…(21:37) Why the line between talking startups and politics is blurring(23:05) Hubspot - Check out the guide “Advanced ChatGPT Prompt Engineering: From Basic to Expert in 7 Days.” Download it for free at clickhubspot.com/twist2.(24:59) Japan doesn’t make a lot of things, but it produces the underlying tech behind a lot of things(25:52) Understanding Genten Shugi: Why some in Japan still have an “English allergy”(29:42) Why some Americans will take a pay cut to come work in Japan(33:28) Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at www.northwestregisteredagent.com/twist(34:10) PITCH #1: Cascade(36:10) PITCH #2: Altsource Global(38:10) PITCH #3: GoalMochi(40:25) Jason, Max, and Fred give feedback on our first three pitches(42:45) Would GoalMochi ever consider adding personas for added expertise, like say a nutritionist?(44:30) How does Cascade plan to compete against the massive ad networks of companies like Google and Meta?(46:05) PITCH #4: RandomChat(48:10) PITCH #5: Eir(50:05) More feedback for our final two pitches of the day(52:44) Fred wants to know how Eir’s product will integrate with other systems(54:19) Why Gigi made herself available to chat in her app(57:50) Why Jason thinks RandomChat should add anonymous personasSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(14:37) Sentry - New users can get $240 in free credits when they go to sentry.io/twist and use the code TWIST(23:05) Hubspot - Check out the guide “Advanced ChatGPT Prompt Engineering: From Basic to Expert in 7 Days.” Download it for free at clickhubspot.com/twist2.(33:28) Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at www.northwestregisteredagent.com/twist
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    1 hr and 3 mins
  • From Blood Transfusions to Burritos, How Zipline is Automating Delivery | E2238

    From Blood Transfusions to Burritos, How Zipline is Automating Delivery | E2238
    Jan 21 2026
    This Week In Startups is made possible by:Northwest Registered Agent - www.northwestregisteredagent.com/twistCrusoe Cloud - https://crusoe.ai/savingsLinkedIn Jobs - http://linkedIn.com/twistToday’s show: On today’s TWIST episode, Alex interviews two of the top startup co-founders: Keller Cliffton of Zipline and Anastasis Germanidis of Runway. Zipline announced its $600 million raise at a $7.6 BILLION valuation. Kellers breaks down the origins, economics, and future of Zipline’s contrarian bet in drone delivery. What was science fiction a decade ago is now a regular part of life for many. In fact, Zipline operates more flights than United!Zipline is set to leapfrog the car delivery apps AND self driving cars with the superior economics of drone delivery. It is much cheaper to transport your burrito in a lightweight drone than a 6,000 pound self driving car!Then, Alex is joined by Anastasis Germanidis, the CTO and co-founder of Runway, to explain why the next frontier of generative AI is world models! Runway is looking to build a universal simulation, which will unlock massive gains in robotics, autonomy, and simulations. The world model would be able to simulate rare edge cases that could take years to find naturally! Check out how this cutting edge AI startup’s NYU Tisch School of Art’s originsThen, See Jason’s answer to the question: “When should founders pivot or give up?”Timestamps: (00:00) The Drone revolution is here!(02:46) Inside Zipline’s factory to build 20K drones a year(04:40) American dynamism Vs. Chinese manufacturing dominance(09:00) How Zipline is growing 75% month on month(9:50) Northwest Registered Agent. Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at www.northwestregisteredagent.com/twist(11:15) Zipline teleports food and goods to your house(21:54) Crusoe Cloud: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit https://crusoe.ai/savings to reserve your capacity for the latest GPUs today.(23:02) Is it affordable to use a drone to deliver a burrito?(29:18) Zipline DOUBLES United’s flight numbers(31:11) LinkedIn Jobs - post your job for free at http://linkedIn.com/twist then promote it to get access to LinkedIn Jobs new AI assistant.(32:21) Anastasis break’s down Runway’s AI modeling(35:24) Runway’s Gen 4.5 and the world model(40:57) Why do robotics companies need a world model?(43:04) Using AI to simulate robot laundry folding(52:37) Runway’s origins at NYU’s art school(55:46) Founder Q/A: When to pivot or give up on your startup*Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com/Check out the TWIST500: https://twist500.com)Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp*Follow Lon:X: https://x.com/lons*Follow Alex:X: https://x.com/alexLinkedIn: https://www.linkedin.com/in/alexwilhelm/*Follow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanis/*Thank you to our partners:(9:50) Northwest Registered Agent. Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at www.northwestregisteredagent.com/twist(21:54) Crusoe Cloud: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit https://crusoe.ai/savings to reserve your capacity for the latest GPUs today.(31:11) LinkedIn Jobs - post your job for free at http://linkedIn.com/twist then promote it to get access to LinkedIn Jobs new AI assistant.Check out all our partner offers: https://partners.launch.co/
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    1 hr and 4 mins
  • How startups suddenly became “cool” in Japan (feat. Shin Takamiya of Globis Capital) | E2237

    How startups suddenly became “cool” in Japan (feat. Shin Takamiya of Globis Capital) | E2237
    Jan 20 2026
    This Week In Startups is made possible by:Circle.so - http://Circle.so/twistDeel - http://deel.com/twistUber AI Solutions - http://uber.com/twistToday’s show:Not long ago, promising young Japanese graduates wanted to go work for the largest, most established, and even oldest corporations: Sony, Mitsubishi, and the like. But now, just over the last few years, more and more Japanese people are becoming entrepreneurs and founders. TWiST Japan continues with a fascinating look inside the country’s growing startup ecosystem with special guest, venture capitalist Shinichi “Shin” Takamiya. He’ll walk Jason through how Japan stayed ahead of the rest of the world in technology, but started falling behind when it came to founding companies, and how the Japanese are now starting to level the playing field.PLUS why his fund, Globis, sees other VC firms as collaborators rather than the competition… How AI is helping Japanese and American founders build their companies more quickly… Why Jason prefers training younger people to become VCs rather than hiring more experienced players… Shin’s guide to eating out in Tokyo… and much more!Timestamps: (00:00) We’re so excited to bring Founder University in Japan!(04:15) Jason and our guest first met 15-25 years ago…(06:06) How is Japan always so far ahead of the rest of the world?(08:29) Globis is one of Japan’s largest and oldest venture capital firms!(10:48) Circle.so - the easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off Circle’s Professional Plan by going to http://Circle.so/twist(12:38) Why founders need to play the long game when it comes to networking(15:03) “The founder is the most precious resource in the startup community”(16:50) Shin takes us inside his Mercari (a massive Japanese marketplace site) investment(18:20) How startups became “cool” in Japan, just recently(19:43) Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit http://deel.com/twist to learn more.(21:09) You don’t have to tell an investor your whole story… just get them interested(25:28) Why Jason likes to train young folks to be VCs, rather than hiring for experience(28:44) The differences between being candid and rude(29:44) Uber AI Solutions - Your trusted partner to get AI to work in the real world. Book a demo with them TODAY at http://uber.com/twist(35:40) Why Globis sees other VC firms as collaborators(39:08) The world’s OLDEST company is 1500 years old… and it’s from Japan…(39:54) Why a lot of great businesses aren’t right for VC investment(43:34) Why picking the right market is so crucial(48:37) When you know the direction of change but can’t predict the timing(50:34) How founders are using AI to build better companies faster(54:39) Shin’s guide to eating out in Tokyo*Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com/Check out the TWIST500: https://twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcp*Follow Lon:X: https://x.com/lons*Follow Alex:X: https://x.com/alexLinkedIn: https://www.linkedin.com/in/alexwilhelm/*Follow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanis/*Thank you to our partners:(10:48) Circle.so - the easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off Circle’s Professional Plan by going to http://Circle.so/twist(19:43) Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit http://deel.com/twist to learn more.(29:44) Uber AI Solutions - Your trusted partner to get AI to work in the real world. Book a demo with them TODAY at http://uber.com/twistCheck out all our partner offers: https://partners.launch.co/
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    58 mins
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