Why Pharmacotherapy Alone May 'Fail' in Complex TRD (Treatment-Resistant Depression)
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Why Pharmacotherapy Alone May 'Fail' in Complex TRD (Treatment-Resistant Depression)
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About this listen
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In this episode, Consultant Psychiatrist, Dr Sanil Rege looks at treatment refractory mood disorders through a psychodynamic lens using a naturalistic study from the Austen Riggs Centre.
A subset of what most see as Treatment-Resistant Depression (TRD) isn't just pharmacological non-response; it's depression embedded within personality organisation, trauma-related aspects, attachment, and unconscious patterns.
This podcast provides clinicians with a psychodynamic perspective to understand how clinical refractoriness to standard pharmacotherapy can be sustained by meaning, defences, and relational patterns, not just neurotransmitters.