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Extend Podcast with Darshan Shah, MD

Extend Podcast with Darshan Shah, MD

Written by: Darshan Shah MD
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About this listen

Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results. That's why this podcast is all about cutting through the noise on how to turn back the aging clock. I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health. Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.2024 Hygiene & Healthy Living Physical Illness & Disease
Episodes
  • 140. Dr. Kelly Casperson: The Hormone Truth About Women's Longevity
    Feb 19 2026

    Most women are taught that aging means decline, less energy, less strength, and less desire. What if the real problem has never been age itself, but untreated hormone loss and outdated medical narratives.

    In this episode of Extend, we sit down with Dr. Kelly Casperson, urologist, hormone expert, and leading voice in women's sexual health, to uncover how hormones shape longevity, muscle, brain health, and quality of life across midlife and beyond. We break down why estrogen, progesterone, and testosterone matter far beyond symptom relief, how the WHI was misinterpreted, and why modern hormone therapy changes the trajectory of aging.

    We also explore how mindset, muscle preservation, vaginal estrogen, blood flow, wearables, and responsive desire redefine what healthy aging and sexual health can look like for women in their 40s, 50s, and beyond.

    Dr. Kelly Casperson is a board certified urologist, author of You Are Not Broken and The Menopause Moment, and host of the You Are Not Broken podcast. Through clinical care, education, and media, she helps women reclaim agency over their hormones, sexuality, and long term health with science driven, compassionate guidance.

    What We Discuss:

    • (02:22) Why aging is driven by hormone and muscle loss, not age

    • (05:30) How mindset shapes longevity, vitality, and sexual health

    • (08:15) Why estrogen, progesterone, and testosterone affect the entire body

    • (12:40) The WHI study, fear based medicine, and what the data actually shows

    • (18:20) Muscle, hormones, and their role in bone, brain, and metabolic health

    • (23:40) Perimenopause, menopause, and why symptoms are often dismissed

    • (30:10) Vaginal estrogen, pelvic health, and preventing long term decline

    • (36:50) Wearables, biomarkers, and how data empowers better decisions

    • (42:30) Exercise, blood flow, and preserving sexual function with age

    • (48:15) Responsive desire, desire mismatch, and the orgasm gap

    • (55:40) Why sexual health is biopsychosocial, not just hormonal

    • (01:02:20) How education, communication, and prevention redefine women's longevity

    Thank You to Our Sponsors:

    IM8: Try IM8 today with a 30-day money back guarantee. You can get 10% off your first order with code DRSHAH at https://im8health.com/discount/DRSHAH.

    Nexthealth: NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/

    Learn more about Dr. Shah:

    Website: https://www.drshah.com/

    Clinic: https://www.next-health.com/

    Instagram:https://www.instagram.com/darshanshahmd/

    Learn more about Dr. Kelly Casperson:

    Website: https://kellycaspersonmd.com/

    Podcast: https://kellycaspersonmd.com/you-are-not-broken-podcast/

    Instagram: https://www.instagram.com/kellycaspersonmd/

    Facebook: https://www.facebook.com/youarentbroken/

    YouTube: https://www.youtube.com/@kellycaspersonmd

    Show More Show Less
    1 hr and 28 mins
  • 139. JJ Virgin: Muscle Over Weight Loss
    Feb 17 2026

    Most people are told to lose weight to get healthy. What if that mindset is the reason metabolic health keeps getting worse, muscle keeps disappearing, and fat loss never lasts.

    In this episode of Extend, we sit down with JJ Virgin, triple board certified nutrition expert and Fitness Hall of Famer, to unpack why muscle, not weight loss, is the true driver of metabolic health and longevity. We break down why calorie counting and macro percentages fail, how protein first nutrition reshapes metabolism, and why building muscle changes insulin sensitivity, fat loss, and aging at every stage of life.

    We also explore how simple strength tests, time efficient training structures, and a muscle first framework can reverse metabolic decline, guide safe GLP-1 use, and help people stop dieting and start rebuilding their health.

    JJ Virgin is a New York Times bestselling author, media personality, and founder of multiple multimillion dollar health brands, including the Mindshare Collaborative. As host of the Well Beyond 40 podcast and a leader in nutrition, fitness, and longevity, she has helped millions rethink aging, build resilient bodies, and optimize healthspan through science driven strategies.

    What We Discuss:

    • (04:10) Why weight loss focused thinking worsens metabolic health

    • (09:05) The difference between losing weight and losing muscle

    • (14:00) Why the scale is the wrong metric for health

    • (18:45) Muscle mass, strength, and metabolic resilience

    • (23:10) Simple strength tests that predict longevity

    • (30:00) Time efficient training using push pull hinge frameworks

    • (36:40) Why steps and daily movement matter more than people think

    • (41:50) HIIT vs zone two and how to prioritize exercise

    • (47:10) Protein first nutrition and why macro percentages fail

    • (55:00) GLP-1s, muscle loss, and how to use them safely

    • (01:06:30) Hormones, thyroid health, and recognizing early warning signs

    • (01:14:20) Why improving metabolic health leads to sustainable fat loss

    Thank You to Our Sponsors:

    Function Health: Learn more and join using my link. Visit www.functionhealth.com/drshah and use gift code DRSHAH25 for a $25 credit toward your membership.

    Timeline: Go to timeline.com/drshah to get 20% off your order.

    Learn more about Dr. Shah:

    Website: https://www.drshah.com/

    Clinic: https://www.next-health.com/

    Instagram:https://www.instagram.com/darshanshahmd/

    Learn more about JJ Virgin:

    Website: https://jjvirgin.com/

    Facebook: https://www.facebook.com/JJVirginOfficial/

    Instagram: https://instagram.com/jj.virgin/

    Youtube: https://www.youtube.com/user/jjvirginvideos

    Podcast: https://jjvirgin.com/main-podcast/

    7 Day Challenge / Protein Calculator: jjvirgin.com/proteinfirst

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    1 hr and 24 mins
  • 138. Dr. Idrees Mughal: Why Most Viral Health Claims Fail
    Feb 12 2026

    Most people assume viral health advice is backed by solid science. What if much of it is built on cherry-picked studies, misleading mechanisms, and narratives designed to sell certainty rather than protect long-term health.

    In this episode of Extend, we sit down with Dr. Idrees Mughal, UK-trained medical doctor and nutrition researcher, to unpack why so many viral health and nutrition claims fail under real scientific scrutiny. We break down how influencers misuse studies, why single papers rarely overturn decades of evidence, and how mechanistic and animal research is often exaggerated to make claims about human health.

    We also explore how to evaluate health information more clearly, from spotting credential misuse and false equivalencies to understanding why human outcome data matters more than anecdotes, trends, or social media engagement.

    Dr. Idrees Mughal, widely known as Dr Idz, is a physician and educator who has built a global following by confronting health misinformation with evidence-based science, helping millions learn how to think critically about nutrition and wellness claims through his platforms and the School of Dr Idz.

    What We Discuss:

    • (04:00) How wellness influencers misuse nutrition science

    • (07:28) Why one study cannot overturn decades of evidence

    • (11:21) Credential misuse and cherry-picked research

    • (15:48) Rodent and preclinical studies vs human outcomes

    • (20:30) Mechanistic speculation and longevity myths

    • (25:22) Social media echo chambers and diet tribalism

    • (30:11) False equivalencies in carnivore and plant-based debates

    • (38:06) Sugar vs artificial sweeteners and what the evidence shows

    • (49:07) Why N=1 anecdotes are not evidence

    • (55:25) When extreme elimination diets may help short term

    • (01:03:59) Why nutrition science is not actually confusing

    Thank You to Our Sponsors:

    IM8: Try IM8 today with a 30-day money back guarantee. You can get 10% off your first order with code DRSHAH at https://im8health.com/discount/DRSHAH.

    NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/

    Learn more about Dr. Shah:

    Website: https://www.drshah.com/

    Clinic: https://www.next-health.com/

    Instagram:https://www.instagram.com/darshanshahmd/

    Learn more about Dr. Idrees Mughal:

    Instagram:https://www.instagram.com/dr_idz/?hl=en

    You Tube: https://www.youtube.com/@dr_idz

    Threads: https://www.threads.com/@dr_idz

    Show More Show Less
    1 hr and 7 mins
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