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Extend Podcast with Darshan Shah, MD

Extend Podcast with Darshan Shah, MD

Written by: Darshan Shah MD
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Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results. That's why this podcast is all about cutting through the noise on how to turn back the aging clock. I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health. Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.2024 Hygiene & Healthy Living Physical Illness & Disease
Episodes
  • 208. Dr. Thais Aliabadi: PCOS & Endometriosis—The Symptoms Women Should Never Ignore
    Oct 15 2026

    What if the painful periods, irregular cycles, unexplained weight gain, acne, and fertility struggles so many women experience aren't something they should simply learn to live with?

    Too often, women are told their symptoms are normal, their lab results look fine, or they're just stressed. But conditions like PCOS (polycystic ovary syndrome) and endometriosis can go unrecognized for years, leaving women without answers while their symptoms continue to affect their health and quality of life.

    In this episode, I'm joined by Dr. Thais Aliabadi, her patients call her Dr. A, an OB-GYN with decades of experience in women's health, for an eye-opening conversation about two of the most commonly misunderstood conditions affecting women's hormones, metabolism, and reproductive health.

    We break down the signs of PCOS and endometriosis, why these conditions are frequently overlooked, and how earlier recognition and individualized treatment can make a meaningful difference.

    In this episode, you'll learn:

    • The warning signs of PCOS, including irregular periods, acne, facial hair, and unexplained weight changes
    • Why women can have PCOS even if they're lean or don't have ovarian cysts
    • How insulin resistance, testosterone, and inflammation are connected to PCOS
    • Why severe menstrual cramps and chronic pelvic pain deserve further investigation for endometriosis
    • How PCOS and endometriosis can affect ovulation, fertility, and ovarian health
    • What AMH testing can—and cannot—tell you about ovarian reserve
    • The roles of birth control, metformin, GLP-1 medications, and lifestyle changes in PCOS management
    • How endometriosis is evaluated and the treatment options available, from hormonal therapies to surgery

    We also explore the connection between hormone health and mental well-being, the challenges women face when seeking a diagnosis, and why listening to patients is one of the most important parts of preventative medicine.

    Your symptoms deserve to be taken seriously. Whether you're struggling with painful periods, irregular cycles, infertility, or unexplained hormonal changes, this conversation will help you better understand what may be happening in your body—and what questions to bring to your healthcare provider.

    Learn more about Dr. Shah:

    Website: drshah.com

    Clinic: next-health.com

    Instagram: @darshanshahmd and @extend_podcast

    Learn more about Dr. Thais Aliabadi:

    Website: draliabadi.com

    Instagram: @drthaisaliabadi

    Thank You to Our Sponsor!

    Momentous: Head to livemomentous.com and use my code DRSHAH at checkout for up to 35% off.

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    1 hr and 7 mins
  • 207. Dr. Jason Wersland: The Science of Recovery—Pain, HRV, Sleep & Your Nervous System
    Oct 13 2026

    We spend so much time thinking about exercise, nutrition, and performance—but I believe recovery may be one of the most overlooked pieces of longevity.

    In this episode, I'm joined by Dr. Jason Wersland, chiropractor and founder of Therabody, whose own experience with debilitating pain after a motorcycle accident ultimately led him to invent the Theragun.

    But this conversation goes far beyond muscle soreness.

    Jason and I explore what recovery actually means, why it isn't just for athletes, and how the way we regulate our nervous system can influence pain, tension, sleep, performance, and how we feel every day. Whether you're training intensely, sitting at a desk for eight hours, standing all day at work, or simply dealing with chronic stress, your body still needs opportunities to recover.

    In this episode, you'll learn:

    • Why recovery should be part of your daily longevity routine—not just something you do after exercise

    • How the "pain gate theory" helps explain why different forms of stimulation can temporarily change how we perceive pain

    • Why sitting all day can contribute to hip, lower-back, neck, and shoulder tension

    • How percussive therapy can affect pain, muscle tension, range of motion, and blood flow

    • Why nervous system regulation matters for recovery and performance

    • How shifting into a parasympathetic state may help you wind down before sleep

    • Why HRV and heart rate can provide useful feedback about recovery

    • How small "recovery snacks" throughout the day can help you take better care of your body

    We also discuss massage, breathwork, movement, compression therapy, biofeedback, sleep, and practical ways to build short recovery "pit stops" into even the busiest schedule.

    One of my biggest takeaways from this conversation is that recovery is not a luxury reserved for professional athletes. Your body is responding to physical, mental, and emotional stress every day. If we want to perform well—and stay healthy for decades—we have to give it opportunities to recover, too.

    Learn more about Dr. Shah:

    Website: drshah.com

    Clinic: next-health.com

    Instagram: @darshanshahmd and @extend_podcast

    Learn more about Dr. Jason Wersland:

    Website: therabody.com

    Instagram: @drjasonwersland

    Thank You to Our Sponsor:

    IM8: Try IM8 with a 30 day money back guarantee. Get 10% off your first order with code DRSHAH at checkout im8health.com/drshah

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    55 mins
  • 206. Dr. Pamela Smith: The Truth About Hormone Replacement Therapy—HRT, Menopause & Cancer Risk
    Oct 8 2026

    Hormones influence far more than reproductive health. They affect your sleep, mood, metabolism, muscle, bone health, brain function, stress response, and how you age—yet hormone health is still often reduced to a handful of numbers on a standard blood test.

    In this episode, I'm joined by Dr. Pamela Smith, a physician who has spent decades practicing and teaching personalized medicine, to break down what women and men need to understand about hormone replacement therapy, healthy aging, and disease prevention.

    We explore estrogen, progesterone, testosterone, DHEA, cortisol, thyroid hormones, insulin, and one hormone many people have never even heard of: pregnenolone. More importantly, we discuss why hormone optimization should never be one-size-fits-all.

    Dr. Smith explains why two people of the same age may need completely different approaches, why testing before treatment matters, and how hormones interact with everything from gut health and methylation to toxins, blood sugar, bone health, and cancer risk.

    In this episode, you'll learn:

    • Why hormone replacement therapy should be personalized to the individual
    • The roles of estrogen, progesterone, testosterone, DHEA, cortisol, thyroid, and pregnenolone
    • What women should understand about hormones and breast cancer risk
    • Why hormone metabolites and methylation may matter
    • How gut health and environmental toxins can influence hormone health
    • Why fasting insulin can reveal metabolic dysfunction before diabetes develops
    • How stress and cortisol affect blood sugar, cholesterol, blood pressure, and bone health
    • Why genetic and advanced testing are changing personalized and preventative medicine

    We also discuss PCOS, menopause, micronutrients, glutathione, environmental toxins, therapeutic plasma exchange, genetic cancer screening, exercise, and the emerging tools that may help us identify disease risk earlier.

    The biggest takeaway from this conversation is simple: optimal health isn't about giving everyone the same protocol. It's about understanding your individual biology, measuring what matters, and intervening before dysfunction becomes disease.

    Learn more about Dr. Shah:

    Website: drshah.com

    Clinic: next-health.com

    Instagram: @darshanshahmd and @extend_podcast

    Learn more about Dr. Pamela Smith:

    Website: centerforprecisionmedicine.com

    Thank You to Our Sponsors!

    Next Health: Your destination for cutting-edge health optimization - from IV therapy and peptides to hormone balancing and TPE. Explore more at next-health.com

    Timeline: Timeline, powered by Mitopure, just dropped in price! Check it out using the link shop.timeline.com/DRDARSHANSHAH for 20% off when you subscribe!

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    54 mins
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