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From Bench to Bedside

From Bench to Bedside

Written by: Drs. Matheu and Rubin
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From Bench to Bedside is a science-forward medical podcast that cuts through the noise, the hype, and the misinformation. Hosted by Dr. Zachary Rubin, MD, a double board-certified pediatrician and allergist/immunologist, and Dr. Melanie Matheu, PhD, an immunologist, scientist and entrepreneur. This podcast brings you the combined perspectives of a medical doctor and PhD scientist on what’s actually happening in medicine, public health, and biomedical science.

Each episode bridges the gap between what the research shows (“the bench”) and what patients experience in the real world (“the bedside”). We break down topics like vaccines, immune system myths, chronic illness claims, viral health trends, and breaking medical news using evidence, clinical reasoning, and scientific context.

Whether you’re a clinician, scientist, student, or just someone trying to make sense of today’s health information landscape, From Bench to Bedside is here to help you think more clearly about health and medicine.

🎙️ New episodes regularly
📍 Educational content only; not medical advice

2026 Drs. Matheu and Rubin
Hygiene & Healthy Living Physical Illness & Disease
Episodes
  • Episode 19 - Small Health Changes That Actually Matter
    Sep 4 2026

    What if improving your health didn’t require completely changing your life?

    In this episode of From Bench to Bedside, Dr. Zachary Rubin and Dr. Melanie Matheu discuss the small, sustainable habits that can have an outsized impact on long-term health.

    From laughter and social connection to movement, strength training, sleep, stress management, nutrition, alcohol, nicotine, and preventive care, Zach and Melanie explore what actually matters while sharing some of the ways they try (and sometimes struggle) to put these habits into practice themselves.

    Because better health doesn’t have to mean perfection.

    Sometimes it means taking a walk after dinner, trying a new hobby, putting your phone down a little earlier, adding more vegetables to your plate, getting enough sleep, or simply making more time for the people and activities that make life enjoyable.

    Pick one or two small changes. Make them sustainable. Let them add up.

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    23 mins
  • Episode 18 - Health Updates You May Have Missed: Outbreaks, Food Safety & Medical Breakthroughs
    Sep 1 2026

    In this episode of From Bench to Bedside, Dr. Zachary Rubin and Dr. Melanie Matheu take a rapid-fire look at some of the biggest recent developments in health, medicine, and public health.

    They discuss the ongoing Cyclospora outbreak and delays in tracing its source, a major beef recall involving products that bypassed import inspection, the Ebola outbreak in the Democratic Republic of Congo, H5N1 bird flu in Australia, extreme heat, flesh-eating bacteria, and the changing geography of tick-borne diseases.

    They also examine an important ruling involving emergency pregnancy care in Idaho before turning to several promising scientific developments, including mRNA influenza vaccines, a new mechanism-based approach to treating narcolepsy, evidence showing the health benefits of reducing air pollution, and a new PET imaging tool for evaluating Alzheimer’s disease.

    It’s a wide-ranging health news roundup featuring both reasons for concern and reasons for optimism, with the science, context, and occasional chaos you expect from From Bench to Bedside.

    Hosted by Dr. Zachary Rubin and Dr. Melanie Matheu, PhD.

    Subscribe and let us know whether you’d like to hear more rapid-fire health news episodes like this one.

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    17 mins
  • Episode 17 - Trump’s New Vaccine Executive Order: What Parents Need to Know
    Aug 31 2026

    President Trump has signed a sweeping executive order that could significantly reshape how childhood vaccines are recommended in the United States.

    In this episode of From Bench to Bedside, Dr. Zachary Rubin and Dr. Melanie Matheu read Executive Order 14420 section by section and examine what it actually says, and what the science says about the changes being proposed.

    The order proposes a new three-tier system for childhood vaccines, changes involving hepatitis A, hepatitis B, RSV and meningococcal disease, greater use of “shared clinical decision-making,” reconsideration of the timing of childhood vaccines, and a push to administer vaccines at separate medical visits whenever possible.

    Perhaps most strikingly, the order calls for the combined MMR vaccine to eventually be offered as three separate measles, mumps and rubella vaccines.

    Drs. Rubin and Matheu explain why separating MMR could dramatically increase the number of injections and medical appointments families need to complete the same vaccine series without evidence that separating the vaccines provides a meaningful safety advantage.

    They also examine the administration’s argument that the United States is an international outlier in childhood vaccination.

    How comparable are countries such as Denmark or other European nations to the United States when their healthcare systems, demographics, disease prevalence and access to physicians can be dramatically different?

    The discussion also covers:

    • How vaccine recommendations are actually developed
    • Why the current childhood vaccine schedule exists
    • RSV prevention in infants
    • Why hepatitis B vaccination begins so early
    • The difference between a recommendation and a school vaccine requirement
    • Vaccine safety monitoring
    • Aluminum vaccine adjuvants
    • How legitimate vaccine safety signals have been handled historically
    • Medical and religious exemptions
    • Federal versus state authority over school vaccine requirements
    • The scientific method and the danger of designing research to reach a predetermined conclusion
    • Why physicians are increasingly worried about public distrust

    Most importantly, this executive order does not suddenly eliminate vaccines or prevent parents from vaccinating their children.

    Many of its provisions would require additional regulatory action, private-sector participation, state action or litigation before they could substantially change what happens in your pediatrician’s office.

    But the direction of childhood vaccine policy in America is changing, and families deserve clear information about what is happening.

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    57 mins
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