Dr. Matt Kaeberlein is a biologist of aging, the CEO of Optispan, and a co-founder of the Dog Aging Project. He is also the founding director of the University of Washington’s Healthy Aging and Longevity Research Institute and has published over 250 papers on longevity. In this conversation, he breaks down why direct-to-consumer longevity products deserve skepticism, what the data actually says about rapamycin and intermittent fasting, and which biomarkers and scans are worth your money.

In this episode, we discuss:
(1:58) Why Matt Kaeberlein Resigned From a Longevity Academy in 2024
(9:14) How to Spot Longevity Hype and Misleading Supplement Claims
(16:31) Lifespan vs. Healthspan: Have We Really Slowed Aging?
(22:01) Curing Cancer Adds 2.5 Years. Slowing Aging Could Add 20.
(24:43) Should Aging Be Classified as a Disease?
(30:59) The Hallmarks of Aging Explained
(39:39) Is VO2 Max the Best Longevity Metric?
(47:29) The Intermittent Fasting Myth: What Mouse Studies Show
(51:38) What Is Rapamycin and Does It Slow Aging?
(58:00) Inside the Dog Aging Project’s Rapamycin Trial
(1:01:19) Does Matt Kaeberlein Recommend Rapamycin?
(1:04:37) Protein Maxing and mTOR: Does More Protein Speed Aging?
(1:11:54) Are Biological Age Tests Accurate?
(1:19:49) The One Biological Age Clock He Trusts: LinAge2
(1:24:29) Best Longevity Spend: $100 vs. $1,000 a Month

Learn more about Dr. Matt Kaeberlein here:
Website: https://kaeberleinlab.org
Optispan: https://www.optispan.life
Dog Aging Project: https://dogagingproject.org
Instagram: https://www.instagram.com/mkaeberlein
X: https://x.com/mkaeberlein
LinkedIn: https://www.linkedin.com/in/mkaeberlein

Watch this episode on Youtube: https://youtu.be/IrfBCWadCm0

📸 Connect with us on IG: https://instagram.com/growthminds.podcast

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Dr. Nathan Bryan is a nitric oxide biochemist and the Founder, Chairman, and CEO of Bryan Therapeutics, with over 25 years of research and 100+ peer-reviewed papers on how the body makes this molecule. He's the author of The Secret of Nitric Oxide: Bringing the Science to Life. In this conversation, he explains how everyday habits like mouthwash, fluoride toothpaste, and antacids can quietly shut down blood flow, why erectile dysfunction can be an early warning sign of heart disease, and the daily routine he follows to protect his own vascular health.

In this episode we discuss:

(0:00) Trailer

(1:48) Mouthwash and Heart Health: The Hidden Link
(2:54) How Antiseptic Mouthwash Raises Blood Pressure in 7 Days
(8:53) Tongue Scraping vs. Antiseptic Mouthwash
(14:13) Why Fluoride-Free Toothpaste Matters for Blood Flow
(15:47) What Is Nitric Oxide? The "Miracle Molecule" Explained
(19:20) Why ED Is the "Canary in the Coal Mine" for Heart Disease
(23:31) Testosterone, TRT, and Nitric Oxide: Which Comes First?
(28:25) Daily Cialis After 40? Dr. Bryan Responds to Huberman
(34:19) How to Test Your Nitric Oxide Levels
(37:50) Dr. Bryan's Warning About Antacids and PPIs
(42:30) Mouth Taping and Nasal Breathing for Better Blood Flow
(45:54) Best Foods for Nitric Oxide (And Why Organic Falls Short)
(54:43) Sauna and Cold Plunge: Boosting Blood Flow Through Hormesis
(58:18) Dr. Bryan's Daily Non-Negotiables: Fasting, HIIT, and Sauna
(1:01:03) Why Sugar Shuts Down Nitric Oxide Production

Learn more about Dr. Nathan Bryan here:

Website: https://n1o1.com

Bryan Therapeutics: https://bryantherapeutics.com

Instagram: https://www.instagram.com/drnathansbryanX: https://x.com/drnitric

LinkedIn: https://www.linkedin.com/in/drnathansbryan

YouTube: https://www.youtube.com/@drnathansbryannitricoxide

Book: The Secret of Nitric Oxide: https://nathansbook.com

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🍎 Apple Podcasts: https://podcasts.apple.com/podcast/id1482999379

📸 Connect with us on IG: https://instagram.com/growthminds.podcast

Made possible by: Jumpspeak: ⁠https://www.jumpspeak.com

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Dr. Catherine Salmon is a Professor of Psychology at the University of Redlands and an evolutionary psychologist who has spent over two decades studying erotic fiction, pornography, and female sexuality. She's the co-author of Warrior Lovers: Erotic Fiction, Evolution and Female Sexuality and The Secret Power of Middle Children, and her research explores what romance novels and porn — the private products billions of people consume — reveal about the evolved mating psychology of men and women.

In this episode, we discuss:

(1:56) What Romance Novels Reveal About What Women Really Want
(2:59) Why Romance Novel Heroes Are Always "Capable" Alpha Men
(6:18) Is Attraction to Wealth Learned or Evolutionary?
(12:17) Bad Boys vs. Nice Guys: The "Dad or Cad" Theory
(16:38) Why Romance Is About Long-Term Mating and Porn Is About Short-Term
(19:52) How Birth Control Changed Women's Short-Term Mating
(32:48) Why Being "Chosen" by a High-Option Man Matters So Much
(42:46) The Hidden Tests Women Use to Screen Men
(43:37) The Gladiator Frog: Nature's Version of a Commitment Test
(50:12) How Porn Is Becoming a Coping Skill for Anxious Young Men
(54:53) Do Dating Apps Create a False Illusion of Abundance?
(1:02:42) What Is "Mismatch Theory"?
(1:10:44) The Link Between Absent Fathers and Earlier Puberty
(1:18:01) Why Middle Children Make the Most Loyal Partners
(1:23:52) What Men and Women Misunderstand About Each Other

Learn more about Dr. Catherine Salmon here:
Website: https://www.redlands.edu/faculty-and-staff-directory/psychology/catherine-salmon
Books: Warrior Lovers: Erotic Fiction, Evolution and Female Sexuality: https://a.co/d/039nhjPpThe Secret Power of Middle Children: https://a.co/d/03p2WXhQ

Watch this on Youtube: https://youtu.be/VuJeYaForIA

📸 Connect with us on IG: https://instagram.com/growthminds.podcast

Made possible by: Jumpspeak: ⁠https://www.jumpspeak.com⁠

Follow Sean Kim
Instagram: https://www.instagram.com/heyseankim/?hl=en
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