Episodes

  • Hope Lies in Dreams trailer

    Hope Lies in Dreams trailer
    Sep 1 2021
    Trailer for upcoming 10-part series, Hope Lies in Dreams.

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    2 mins
  • Chapter 1: an ugly place

    Chapter 1: an ugly place
    Sep 8 2021
    Stan Crooke is born ⬩ A tenuous existence ⬩ Life with his mother ⬩ The Tech Corner ⬩ Arsenal Tech High School ⬩ Nancy ⬩ Hoodlum ways ⬩ Off to Purdue

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    32 mins
  • Chapter 2: a winding path

    Chapter 2: a winding path
    Sep 15 2021
    Quits Purdue ⬩ Pharmacy school ⬩ Off to Baylor ⬩ Harris Busch ⬩ Bristol Labs ⬩ SmithKline ⬩ The death of Nancy Crooke ⬩ The end of SmithKline

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    47 mins
  • Chapter 3: San Diego restart

    Chapter 3: San Diego restart
    Sep 22 2021
    Rosanne ⬩ An investor emerges ⬩ Founding Isis ⬩ The old garage ⬩ A proper space ⬩ A growing antisense scene ⬩ Starting a pipeline ⬩ Isis goes public

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    48 mins
  • Chapter 4: three kinds of failure

    Chapter 4: three kinds of failure
    Sep 29 2021
    Stumbling out of the gate ⬩ Launch of Vitravene ⬩ Questions about antisense ⬩ The field thins ⬩ Clinical failure ⬩ The darkest days

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    44 mins
  • Chapter 5: valley of antisense

    Chapter 5: valley of antisense
    Oct 6 2021
    The genomics bubble ⬩ Affinitak fails ⬩ Lynne saves the company ⬩ Hybridon pivots ⬩ New chemistries ⬩ Regulus formed ⬩ Isis as cult

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    42 mins
  • Chapter 6: lone voice in the wilderness

    Chapter 6: lone voice in the wilderness
    Oct 13 2021
    Rosanne saves the company ⬩ Ibis is sold ⬩ An approval ⬩ Souring on Genzyme ⬩ The end of Genta ⬩ The discovery of the SMA gene

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    43 mins
  • Chapter 7: the SMA gang

    Chapter 7: the SMA gang
    Oct 20 2021
    The Larsons ⬩ The skunkworks project ⬩ The most unmet need ⬩ Instant synergy ⬩ Another first for antisense ⬩ The clinic, again ⬩ The achievements of Kathie Bishop

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    40 mins