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I Bet You Didn’t Know

I Bet You Didn’t Know

Written by: Circle Of Insight Productions
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A podcast that will make you question everything you knew about the world by dispelling myths and misconceptionsCopyright Circle Of Insight Productions
Episodes
  • Antidepressants Made Simple: SSRIs, SNRIs, TCAs & MAOIs

    Antidepressants Made Simple: SSRIs, SNRIs, TCAs & MAOIs
    Sep 29 2026
    Antidepressant pharmacology becomes easier when medications are organized by mechanism rather than memorized as disconnected names. This episode compares the major antidepressant classes and the clinical considerations that distinguish them. The emphasis is on building a framework for board questions and clinical reasoning, not prescribing advice for any individual patient.
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    3 mins
  • Why Antidepressants Lose Their Edge: Neuroadaptation and Loss of Response

    Why Antidepressants Lose Their Edge: Neuroadaptation and Loss of Response
    Oct 12 2026
    Antidepressants shift neurotransmission within hours or days, yet meaningful clinical improvement typically takes weeks — and for some patients, a treatment that worked initially can lose its effect over time. This episode breaks down the mechanisms behind that delayed and sometimes fading response, covering receptor signaling, neural adaptation, HPA-axis and stress circuitry involvement, and neuroplasticity in depression treatment. For PMHNP practice, this moves well past the outdated chemical-imbalance explanation and into the receptor-level and circuit-level changes that actually drive clinical outcomes. It's a focused look at the pharmacodynamics behind "tachyphylaxis" and why antidepressant response is far more complex than symptom relief alone.
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    4 mins
  • Neurotransmitters Made Simple: Serotonin, Dopamine, Norepinephrine, GABA, and Glutamate

    Neurotransmitters Made Simple: Serotonin, Dopamine, Norepinephrine, GABA, and Glutamate
    Oct 4 2026
    Neurotransmitters are fundamental to understanding psychiatric disorders and psychopharmacology—and they are essential knowledge for the PMHNP exam. In this episode of PMHNP in the Car, we break down five major neurotransmitters: serotonin, dopamine, norepinephrine, GABA, and glutamate. You’ll learn their primary functions, how abnormal activity may be associated with psychiatric symptoms, and which medications influence each system. We’ll also connect neurotransmitters to depression, anxiety, schizophrenia, ADHD, and other commonly tested disorders. The goal is to help you move beyond memorization and understand the clinical logic behind psychiatric medications.
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    5 mins
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