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Knife Down

Knife Down

Written by: Lily Johnston MD MPH
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About this listen

"Knife Down" is what a surgeon says in the OR when she puts her scalpel down so no one gets hurt — and it’s the mission here: put the knife down, long before anyone needs to use it.


Knife Down is a podcast about how to actually invest in your health so you can live longer, stronger, and with less time in doctors’ offices. The core focus is the world’s leading cause of death—cardiovascular disease—and what to do about it before it shows up as a catastrophe.


Hosted by a vascular surgeon on a mission to put herself out of business, the show translates cutting-edge science on prevention, metabolic health, and longevity into real-world strategies you can use in clinic or at your kitchen table. Expect evidence, nuance, and zero wellness hype—plus the occasional dark joke about the state of modern medicine.

© 2026 Knife Down
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Episodes
  • The Truth About Aspirin and Heart Attack Prevention
    Apr 27 2026

    I've seen daily aspirin save lives from heart attack — and cause fatal bleeds. As a vascular surgeon, here's my honest take on heart health.

    The answer isn't yes or no — it depends entirely on who you are.

    In this video I break down the three groups you need to know:

    ✅ Who SHOULD take daily aspirin — if you've already had a heart attack, stroke, or stent, aspirin for secondary prevention of heart disease is still one of the most evidence-backed interventions we have.

    ❌ Who SHOULD NOT — the 2022 USPSTF guidelines quietly changed the recommendations for primary prevention. If you haven't had a cardiovascular event, daily aspirin may be doing more harm than good.

    ⚠️ The gray zone — two situations where the answer gets complicated: elevated coronary artery calcium (CAC) scores and high Lp(a) (lipoprotein a). Both raise your cardiovascular risk in ways the standard guidelines don't fully account for.

    This is the conversation your doctor should be having with you — but often doesn't have time for.

    I'm a vascular surgeon teaching the prevention side of medicine — the part most doctors don't have time to cover. Subscribe for more evidence-based answers on heart disease, metabolic health, and longevity.

    Sign up for more information on my own practice here: https://corsighthealth.com/

    High Quality 3rd-party tested supplements at Fullscript (10% discount): https://us.fullscript.com/welcome/ljohnstonmd/store-start

    Other tools for optimal health (note these are affiliate links):
    Home BP Cuff: https://amzn.to/49Cq7rh
    Sonicare Toothbrush: https://amzn.to/3KllfMS
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    Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d
    Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS
    Intake Breathing Nasal Support: https://amzn.to/48dfQQ1
    Personal Blender: https://amzn.to/4pyNGGl
    True Nutrition Protein: https://oken.do/q2xzqeqw
    Glass Meal Prep Containers: https://amzn.to/4ocEPJ2
    Sleep Mask: https://amzn.to/48fSJV5
    Air Purifier: https://amzn.to/4puzTQZ

    ___________________________
    🧬 About Dr. Lily Johnston

    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.

    #MetabolicHealth #CardiovascularPrevention #HeartHealth #Longevity #InsulinResistance #DrLilyJohnston #DrLily #WomenInMedicine #Surgeon #VascularSurgeon #PreventiveMedicine #PADPrevention #HeartAttackRisks #HealthPortfolio #California #SanDiego #Arizona #Virginia #Minnesota

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    24 mins
  • Ask Me (Almost) Anything With Dr Johnston | Live Q&A
    Apr 20 2026

    We hit all the high points today! Nutrition, exercise, lipids, dental health, hormones, and more. We had amazing participation and it was wonderful to have a chance to interact with everyone in real time. Thanks SO much for taking some of your precious weekend to talk cardiovascular health, heart scans, CAC scores, and all the other nerdy prevention things with me. Hope you enjoyed it! If you want me to do more of these in the future, please say so in the comments!

    Water filters that remove microplastics:
    Clearly Filtered Pitcher: https://a.co/d/0e2GGJ1c
    LifeStraw 18-cup Water Filter Dispenser: https://a.co/d/0a7rPQKM

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    Glass Meal Prep Containers: https://amzn.to/4ocEPJ2
    Air Purifier: https://amzn.to/4puzTQZ

    Dental Hygiene Tools I Use:
    Sonicare Toothbrush: https://amzn.to/3KllfMS
    WaterPik: https://amzn.to/4894Xi8

    High Quality 3rd-party tested supplements at Fullscript (10% discount): https://us.fullscript.com/welcome/ljohnstonmd/store-start

    Other tools for optimal health (note these are affiliate links):
    Home BP Cuff: https://amzn.to/49Cq7rh
    Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d
    Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS
    Intake Breathing Nasal Support: https://amzn.to/48dfQQ1
    Personal Blender: https://amzn.to/4pyNGGl
    True Nutrition Protein: https://oken.do/q2xzqeqw
    Sleep Mask: https://amzn.to/48fSJV5


    ___________________________
    🧬 About Dr. Lily Johnston

    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.

    Show More Show Less
    1 hr and 43 mins
  • Can You Unclog Arteries? A Vascular Surgeon Reacts to Dr Kevin Ham ​
    Apr 13 2026

    Plaque reversal is one of the most debated topics in preventive cardiology, so in this video I react to Dr. Kevin Ham’s CAST protocol for plaque reversal: Causes, Adding Cures, Strengthening the Body, and Training the Mind and Body.

    Overall, I think this is a thoughtful framework and I agree with much of it. But as a vascular surgeon who treats advanced atherosclerosis, I also add some nuance around what “plaque reversal” really means, what may be missing from this conversation, and where I’d want more granularity in a real-world cardiovascular prevention plan.

    We talk about the causes of plaque buildup, metabolic health, lifestyle change, cardiovascular risk reduction, and the difference between improving risk factors versus actually changing plaque biology. I also share where I think protocols like this can be helpful—and where they risk oversimplifying atherosclerosis.

    If you’re trying to understand plaque reversal, atherosclerosis, heart disease prevention, metabolic health, LDL, ApoB, inflammation, insulin resistance, and cardiovascular risk, this video will help you think more clearly about the problem.

    Let me know in the comments: Do you think “plaque reversal” is a useful term, or does it create more confusion than clarity?

    #PlaqueReversal #Atherosclerosis #HeartDisease #CardiovascularHealth #MetabolicHealth #Prevention

    High Quality 3rd-party tested supplements at Fullscript (10% discount): https://us.fullscript.com/welcome/ljohnstonmd/store-start

    Other tools for optimal health (note these are affiliate links):
    Home BP Cuff: https://amzn.to/49Cq7rh
    Sonicare Toothbrush: https://amzn.to/3KllfMS
    WaterPik: https://amzn.to/4894Xi8
    Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d
    Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS
    Intake Breathing Nasal Support: https://amzn.to/48dfQQ1
    Personal Blender: https://amzn.to/4pyNGGl
    True Nutrition Protein: https://oken.do/q2xzqeqw
    Glass Meal Prep Containers: https://amzn.to/4ocEPJ2
    Sleep Mask: https://amzn.to/48fSJV5
    Air Purifier: https://amzn.to/4puzTQZ

    ___________________________
    🧬 About Dr. Lily Johnston

    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.

    Show More Show Less
    21 mins
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