Rodrigo Brandão joins co-hosts Kate d'Adamo and Daniel W.K. Lee to explore the evolving role of media, activism, and art in driving social change. Rodrigo recounts his path from film student to communications leader, highlighting the value of storytelling and community in organizing. The episode examines the struggle for independent journalism, the strategic use of social media, and the need for inclusive coalitions. Listeners gain insight into Rodrigo’s philosophy of joyful, art-infused activism and the lessons learned from both Brazilian and American movements.

The sugar cookies get extra sprinkles with this December Reply All episode recorded LIVE at the end of 2025 featuring Mattie Bynum, Kenyon Farrow, Daniel W.K. Lee, and Shane Lukas as the team concludes with a "year-in-review" analysis of the most overlooked and over-focused LGBTQ+ stories of 2025, including the impact of government funding cuts on HIV/AIDS programs and the often-ignored role of class within the queer community. Despite the year's hardships, the hosts share their personal highlights—from literary awards to returning to the acting stage—and set their intentions for continued advocacy and community building in 2026.

Shawn Aaron takes the guest seat in conversation with co-hosts Mattie Bynum and Shane Lukas to discuss the origins of his organization, Dem Bois Inc., which advocates for access to gender-affirming care and surgeries for trans men of color. He shares deeply personal accounts of past homelessness and family struggles, emphasizing his core philosophy that "visibility equals possibility". By being open about his own story, Shawn aims to be a beacon for others who may currently be in difficult circumstances, showing them that a different future is possible.

In this episode, co-host team members Mattie Bynum and Shane Lukas talk with The New York Times-lauded author Mattilda Bernstein Sycamore about the "urgency" of queer storytelling and the importance of refusing the terms of dominant culture. Mattilda describes their process of meshing fiction with historical reality to capture the "spectacular intimacy" of queer life in the 1980s and 90s.They share how their early experiences with sex work and the AIDS crisis shaped their commitment to "experimental" writing and vulnerability plus shares insights into their most recent critically-celebrated book 'Terry Dactyl'.

In this episode, podcast co-host team members Mattie Bynum and Daniel W.K. Lee hang out with William Torres Fuentes to discuss the "rainbow of colors" in Puerto Rican culture and how moving to North Carolina forced him to redefine his identity in his 30s and 40s. He details the specific challenges facing the undocumented community, such as the fear that ICE raids create, which often prevents people from seeking life-saving medical care . William explains how he uses creative solutions like virtual appointments and pharmacy shipping to ensure his clients remain healthy despite these external threats. He also stresses the importance of advocacy, recounting his time at "AIDS Watch" on Capitol Hill fighting for PrEP access and continued funding for programs like HOPWA.

Kitty Stryker, activist, journalist, and author of Ask: Building Consent Culture, joins co-hosts Shane Lukas and Hunter to delve into the complex conversation surrounding consent culture. She shares the origins of her work in the Bay Area kink community, her background driving attention to mutual aid and the importance of sustainable communities, and embracing accountability to move closer to a full consent culture.

"Tub Talks" vlogger and therapist Damon Jacobs shares the evolution of sexual health conversations, the impact of PrEP, and the importance of integrating personal and political positions for a more satisfying life with co-hosts Mattie Bynum and Kate d'Adamo.

As the founder of the Outlaw Project, Monica Jones shares her story with hosts Mattie Bynum and Shane Lukas, detailing how her lived experience and the impact of activist Sharmus Outlaw the organization's work on secure housing, harm reduction, and policy to support trans people.