Bremelanotide, also known as PT-141, is one of the most misunderstood sexual health medications available today, and it has one of the strangest origin stories in modern medicine. It was originally studied as a tanning drug, but researchers noticed an unexpected side effect—spontaneous erections. That discovery led scientists to remove the skin-darkening component, resulting in bremelanotide as we know it today.

In this episode, we explain how PT-141 works on the brain rather than blood flow, why it’s considered an option for psychogenic erectile dysfunction in men, and why the same medication is used to increase sexual arousal in women. We break down what it does, what it doesn’t do, common misconceptions, and how it fits into a more honest conversation about desire, arousal, and sexual health.

That’s the short version. The full story is more nuanced, more interesting, and challenges a lot of what people think they know about ED meds and libido. To understand why bremelanotide works so differently—and who it may actually be appropriate for—you’ll have to listen to the episode.

Hedonism II is a resort in Jamaica that’s split between two worlds: half clothing-optional, half nude-mandatory. It’s a place intentionally designed for adults who want freedom, curiosity, and connection without judgment.

Yes, people can have sex under the moon and stars. But they can also spend the day by the pool, dance all night long, and end up talking to a stranger in a hot tub at 4 a.m. who somehow feels like an old friend. The energy moves easily between playful, intimate, social, and surprisingly normal.

To separate myth from reality, we’re joined by the hosts of the Casual Swingers podcast, a couple who have been to Hedonism II more than 70 times. They aren’t marketers or first-timers chasing shock value. They’re regular people who keep coming back and have seen just about every version of the resort there is.

They explain what “casual” actually means in this context, how consent and boundaries work in real life, what newcomers tend to misunderstand, and why Hedonism II is far less about pressure or performance than outsiders assume. For some guests it’s a once-in-a-lifetime experience. For others, it becomes a place of community, freedom, and familiarity that’s hard to find anywhere else.

Addyi was marketed as a breakthrough. But is one additional satisfying sexual experience per month, on average, worth abstaining from alcohol and accepting the risk of meaningful side effects? That question sits at the center of a drug that genuinely helps some people, while confusing and disappointing many others.

In this episode, we break down what Addyi actually is, what the clinical trials showed, why FDA approval was so controversial, and who this medication may or may not make sense for in real world practice. We also explore why treating desire pharmacologically is far more complicated than treating erections, and why comparisons to Viagra have always fallen short.

If you have ever wondered why Addyi inspires both hope and skepticism, this episode explains why.