• Your HIV Risk Is Probably Lower Than You Think
    Feb 18 2026

    Sex is good. Fear-based sex education is not.

    In this episode, we take an honest, evidence-based look at HIV transmission — what your real risk actually is, how it’s measured, and why it’s often dramatically misunderstood.

    We break down:

    • Per-act HIV transmission rates (vaginal, anal, oral)
    • Why receptive anal sex carries higher risk — and what that actually means numerically
    • What U=U (Undetectable = Untransmittable) truly means
    • How viral load changes risk
    • How PrEP reduces transmission
    • Where DoxyPEP fits — and where it doesn’t
    • Why panic often spreads faster than the virus

    HIV is serious. It is also manageable, preventable, and in many contexts, far less transmissible than most people assume.

    Understanding risk doesn’t encourage recklessness. It reduces stigma. It reduces fear. And it allows adults to make informed decisions about their bodies and relationships.

    Sex is good. Let’s talk about it like adults.

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    39 mins
  • The Spicy and Naughty History of Valentine's Day
    Feb 10 2026

    The more things change, the more they stay the same — and Valentine’s Day has always been about sex.

    Long before heart-shaped chocolates and prix-fixe dinners, Valentine’s Day involved nearly naked young Roman men running through the streets and whipping women with goat skins to promote fertility. And yes — women lined up for it.

    In this episode, the Sex Is Good podcast team dives into the sexy, strange, and unapologetically spicy history of Valentine’s Day, separating romantic myth from biological reality and cultural truth.

    If you’re smart enough to listen to a science-based podcast about sex, you’re also smart enough to avoid subscription traps, poor customer service, and incomplete STI testing.

    Take care of your sexual health — without the nonsense — at www.shamelesscare.com.

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    27 mins
  • The ED Drug That Works in Your Brain, Not Your Penis
    Feb 3 2026

    Erections aren’t always a blood flow problem.

    In this episode, we break down apomorphine, an ED medication that works in the brain, not the penis. Unlike sildenafil or tadalafil, apomorphine targets dopamine pathways involved in sexual arousal, motivation, and performance anxiety.

    Rugiet has been advertised apomorphine a lot, but is it safe? Is it effective?

    Wasn't it used to induce vomiting? Can it really be used for erectile dysfunction?

    We explain how and why apomorphine works, who it’s actually for, how it differs from traditional ED medications, and why combining central and peripheral treatments can make a real difference for some men.

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    32 mins
  • Your Brain on BDSM: The Psychology Behind Power, Trust, and Desire with Dr. Stephanie Sigler PhD
    Jan 30 2026

    BDSM is one of the most misunderstood areas of human sexuality. For many people, it’s assumed to be dangerous, pathological, or a sign that something is “wrong.” The psychology tells a very different story.

    In this episode, we’re joined by certified sex therapist Dr. Stephanie Sigler to unpack what actually happens in the brain during consensual power exchange, why trust and communication are central to BDSM, and how these dynamics can be psychologically healthy for many people.

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    51 mins
  • Bremelanotide (PT-141): The Desire Drug That Works on Your Brain, Not Your Blood Flow
    Jan 27 2026

    Bremelanotide, also known as PT-141, is one of the most misunderstood sexual health medications available today, and it has one of the strangest origin stories in modern medicine. It was originally studied as a tanning drug, but researchers noticed an unexpected side effect—spontaneous erections. That discovery led scientists to remove the skin-darkening component, resulting in bremelanotide as we know it today.

    In this episode, we explain how PT-141 works on the brain rather than blood flow, why it’s considered an option for psychogenic erectile dysfunction in men, and why the same medication is used to increase sexual arousal in women. We break down what it does, what it doesn’t do, common misconceptions, and how it fits into a more honest conversation about desire, arousal, and sexual health.

    That’s the short version. The full story is more nuanced, more interesting, and challenges a lot of what people think they know about ED meds and libido. To understand why bremelanotide works so differently—and who it may actually be appropriate for—you’ll have to listen to the episode.

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    35 mins
  • What Is Hedonism II Resort? Interview With a Couple Who Has Visited Over 70 Times
    Jan 23 2026

    Hedonism II is a resort in Jamaica that’s split between two worlds: half clothing-optional, half nude-mandatory. It’s a place intentionally designed for adults who want freedom, curiosity, and connection without judgment.

    Yes, people can have sex under the moon and stars. But they can also spend the day by the pool, dance all night long, and end up talking to a stranger in a hot tub at 4 a.m. who somehow feels like an old friend. The energy moves easily between playful, intimate, social, and surprisingly normal.

    To separate myth from reality, we’re joined by the hosts of the Casual Swingers podcast, a couple who have been to Hedonism II more than 70 times. They aren’t marketers or first-timers chasing shock value. They’re regular people who keep coming back and have seen just about every version of the resort there is.

    They explain what “casual” actually means in this context, how consent and boundaries work in real life, what newcomers tend to misunderstand, and why Hedonism II is far less about pressure or performance than outsiders assume. For some guests it’s a once-in-a-lifetime experience. For others, it becomes a place of community, freedom, and familiarity that’s hard to find anywhere else.

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    1 hr and 2 mins
  • Addyi: What Happens When Medicine Tries to Treat Desire
    Jan 20 2026

    Addyi was marketed as a breakthrough. But is one additional satisfying sexual experience per month, on average, worth abstaining from alcohol and accepting the risk of meaningful side effects? That question sits at the center of a drug that genuinely helps some people, while confusing and disappointing many others.

    In this episode, we break down what Addyi actually is, what the clinical trials showed, why FDA approval was so controversial, and who this medication may or may not make sense for in real world practice. We also explore why treating desire pharmacologically is far more complicated than treating erections, and why comparisons to Viagra have always fallen short.

    If you have ever wondered why Addyi inspires both hope and skepticism, this episode explains why.

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    47 mins
  • The Fascinating (Yes, Really!) History of Chlamydia
    Jan 16 2026

    www.shamelesscare.com is your go to for all your prescription sexual health needs. Use coupon code podcast for $15 off today. No subscriptions - ever!

    Chlamydia has been around far longer than most people realize, long before antibiotics, modern testing, or even a clear understanding of what it was. In this episode, we walk through the surprisingly fascinating history of chlamydia, how it was misunderstood for centuries, how it was finally identified, and why those early blind spots still affect STI testing and diagnosis today.

    This isn’t a scare tactic and it’s not a moral lecture. It’s a look at how medicine actually evolves, how “common and treatable” doesn’t always mean “harmless,” and why chlamydia continues to be one of the most frequently missed and misunderstood infections in sexual health.

    If you’ve ever wondered why chlamydia is so common, why so many people have no symptoms, or why testing still fails people in very predictable ways, this episode will connect some dots.

    Yes, really. It’s fascinating.


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    33 mins