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TPE Blueprint

TPE Blueprint

Written by: MDLifespan
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Unlock the secrets of vitality, clarity, and peak performance with "The TPE Blueprint," the first podcast dedicated to the groundbreaking science of Therapeutic Plasma Exchange (TPE). Hosted by Joe Fier and powered by MDLifespan, this podcast delves into the transformative world of TPE, a revolutionary method that detoxifies your blood by removing harmful toxins and inflammatory proteins. Join us for insightful discussions with experts, inspiring patient success stories, and practical strategies designed to empower you with actionable knowledge. Each short, impactful episode is perfect for both wellness enthusiasts and medical professionals. Learn how TPE can restore cognitive function, enhance heart health, boost athletic performance, and support autoimmune conditions. Discover the anti-aging benefits that make TPE a true game changer for vitality.Copyright 2026 MDLifespan Hygiene & Healthy Living Science
Episodes
  • Mold Exposure: Why Your Home Might Be the Root Cause of Chronic Health Issues - Brian Karr
    Jan 20 2026

    Get your step-by-step MOLD DETOX GUIDEBOOK: mdlifespan.com/mold

    Is your body’s mystery symptom not actually coming from your body? That’s the provocative question at the heart of this episode of the TPE Blueprint. Today, Joe Fier sits down with renowned mold expert Brian Karr to break down why your home—no matter how clean or dry—might be quietly undermining your health. Mold isn’t just a concern for flood victims or humid climates. One microscopic leak could be quietly affecting your lungs, gut, skin, and even long-term chronic conditions—whether or not you ever see, smell, or suspect a thing.

    If you care about optimizing health, longevity, or simply want to stop chasing unexplainable symptoms, this is a game-changing conversation.

    Topics Discussed

    1. Why health symptoms may stem from environmental factors—not just internal ones
    2. Mold's impact on lungs, gut, and skin—and how exposure happens without you noticing
    3. Mold misconceptions: Why dryness or cleanliness doesn’t guarantee safety
    4. How the air you breathe can influence multiple body systems
    5. Trend of increasing home exposure since the shift to remote work
    6. Subtle water damage: Small leaks and drips as major mold risks
    7. Challenges with conventional mold testing and what usually gets overlooked
    8. The Dust Test: A simple, at-home method to reveal mold in your environment
    9. Exposure mapping: Prioritizing fixes in your home based on your health data
    10. 80/20 approach to remediation—focus on what moves the needle most
    11. Easy and fast tips to cut mold exposure: air filtration, air flushing, and dust cleaning
    12. Why symptoms can differ among family members—even in the same house

    Resources Mentioned

    1. The Dust Test: https://thedusttest.com/
    2. Free Consult with We Inspect: https://yesweinspect.com/call?wi_bnd=WIP&wi_plf=Podcast&wi_mch=Guest&wi_cmp=TPE%20Podcast
    3. Free Clean Your Moldy Stuff Guide: www.CleanMyMoldyStuff.com
    4. Top Remediation Mistakes: www.RemediationMistakes.com

    Connect with Us

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    41 mins
  • Doctor Explains How Toxins Destroy the Gut Lining - Dr. Nikol Hopkins
    Jan 14 2026

    In this episode, Joe Fier welcomes integrative medicine expert Dr. Nikol Hopkins for an eye-opening conversation about gut health, toxins, and the power of personalized medicine. Dr. Nikol Hopkins breaks down what “leaky gut” really means, why gut health is more than just what you eat, and how environmental toxins can disrupt your body’s natural balance. Personal stories and simple analogies make this episode a must-listen for anyone seeking practical steps to support their gut, minimize toxic exposure, and understand testing options for optimal health.

    Topics Discussed

    1. The Importance of Gut Health: Why the gut is the body’s gatekeeper, its protective lining, and what happens when it’s compromised.
    2. Leaky Gut Explained: What intestinal permeability means, how it’s connected to inflammation, and why it matters for whole-body health.
    3. Toxins and Their Impact: Which toxins (mycotoxins, heavy metals, PFAs) are most disruptive to gut health, and how they infiltrate the body through food and environment.
    4. Common Culprit Foods: The five most likely foods to trigger issues—dairy, corn, soy, sugar, and wheat—and how elimination programs can provide clarity.
    5. Mycotoxins in Food and Coffee: Surprising sources of mold toxins, including grains and coffee, and why even quality roasting doesn’t always protect you.
    6. How to Heal and Support the Gut: Practical steps including elimination diets, supplements, and the power of personalized testing.
    7. Testing & Interpreting Data: The value of toxin panels and personalized analysis to create an effective avoidance and healing strategy.
    8. Everyday Detox Strategies: How to start reducing exposure—like swapping out plastic kitchenware, nonstick pans, and processed foods for safer alternatives.
    9. Taking Action in Your Home: Step-by-step advice for making your space healthier, from air and water purification to investigating food packaging choices.
    10. The Role of Personalized Medicine and TPE: How Therapeutic Plasma Exchange (TPE) and MD Lifespan’s protocols can be a next step for those at the end of their rope with chronic illness.
    11. Advocating for Your Health: Why you have to be your own health advocate in today’s world and take small steps to protect you and your family.

    Resources Mentioned

    1. Super Gut by Dr. William Davis: https://drdavisinfinitehealth.com/product/super-gut/
    2. Environmental Working Group (EWG): https://www.ewg.org/
    3. Made Safe:
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    46 mins
  • The 5 Episodes That Changed How We Think About Toxins, Health, and Healing
    Dec 24 2025

    What if optimizing your health wasn’t just about diet, exercise, or the latest supplement, but hinged on the very “oil” running through your system? In this recap episode of the TPE Blueprint Podcast, host Joe Fier is back at some of our most impactful episodes of the year. We’ll take a look at conversations with Dr. Paul Savage, Dr. Jill Carnahan, Dr. Paul Anderson, Dr. Janet Eng, and Dr. Muhammad Mansour, to break down therapeutic plasma exchange (TPE), mitochondria’s critical role in health, toxic burden from mold, and actionable strategies for real healing. Whether you’re biohacking or desperate for answers, this episode digs beneath the surface to challenge conventional medicine and empower your physiological reset.

    Topics Discussed

    1. What Is Plasma Exchange? Dr. Paul Savage breaks down the history and modern mechanics of TPE—and why it’s not a fad.
    2. The Car Analogy for Your Health: How your body’s plasma exchange is like an oil change for your engine, and why cellular “cleanliness” matters.
    3. Mitochondria & Cellular Mechanics: The role of mitochondria in energy production and disease, with Joe Fier and guests highlighting how toxins can slow you down at the cellular level.
    4. The Menace of Mold: Dr. Jill Carnahan explains mold’s surprisingly high prevalence, why genetics matter, and how environmental toxins can disrupt everything from your cardiovascular system to your hormones.
    5. Building and Environmental Health:Modern building trends and errors that lead to hidden water intrusion—and how your home’s design may affect your well-being.
    6. Assessment and Personalized Care: Dr. Janet Eng and Dr. Muhammad Mansour discuss unique approaches to evaluating metabolism, body composition, and toxic burden, emphasizing a multimodal, tailored plan for every patient.
    7. Advanced Therapies & Testing: From blood and urine screens to light therapies, what works and why there isn’t a “silver bullet” in recovery.
    8. Sympathetic Overdrive & Parasympathetic Healing: How modern stress affects our ability to heal, and practical tactics to shift toward true rest and recovery.

    Full Episodes to Check Out

    1. Dr. Paul Savage: https://mdlifespan.com/tpe-bp-podcast/tpe-blueprint-ep-03-what-is-plasma-exchange-a-deep-dive-with-dr-paul-savage/
    2. Dr. Jill Carnahan: https://mdlifespan.com/tpe-bp-podcast/tpe-blueprint-podcast-ep-19-is-mold-behind-your-fatigue-brain-fog-dr-jill-carnahan-unpacks-the-hidden-epidemic-breakthrough-detox-solutions/
    3. Dr. Paul Anderson:
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    22 mins
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