• Mold Exposure: Why Your Home Might Be the Root Cause of Chronic Health Issues - Brian Karr
    Jan 20 2026

    Get your step-by-step MOLD DETOX GUIDEBOOK: mdlifespan.com/mold

    Is your body’s mystery symptom not actually coming from your body? That’s the provocative question at the heart of this episode of the TPE Blueprint. Today, Joe Fier sits down with renowned mold expert Brian Karr to break down why your home—no matter how clean or dry—might be quietly undermining your health. Mold isn’t just a concern for flood victims or humid climates. One microscopic leak could be quietly affecting your lungs, gut, skin, and even long-term chronic conditions—whether or not you ever see, smell, or suspect a thing.

    If you care about optimizing health, longevity, or simply want to stop chasing unexplainable symptoms, this is a game-changing conversation.

    Topics Discussed

    1. Why health symptoms may stem from environmental factors—not just internal ones
    2. Mold's impact on lungs, gut, and skin—and how exposure happens without you noticing
    3. Mold misconceptions: Why dryness or cleanliness doesn’t guarantee safety
    4. How the air you breathe can influence multiple body systems
    5. Trend of increasing home exposure since the shift to remote work
    6. Subtle water damage: Small leaks and drips as major mold risks
    7. Challenges with conventional mold testing and what usually gets overlooked
    8. The Dust Test: A simple, at-home method to reveal mold in your environment
    9. Exposure mapping: Prioritizing fixes in your home based on your health data
    10. 80/20 approach to remediation—focus on what moves the needle most
    11. Easy and fast tips to cut mold exposure: air filtration, air flushing, and dust cleaning
    12. Why symptoms can differ among family members—even in the same house

    Resources Mentioned

    1. The Dust Test: https://thedusttest.com/
    2. Free Consult with We Inspect: https://yesweinspect.com/call?wi_bnd=WIP&wi_plf=Podcast&wi_mch=Guest&wi_cmp=TPE%20Podcast
    3. Free Clean Your Moldy Stuff Guide: www.CleanMyMoldyStuff.com
    4. Top Remediation Mistakes: www.RemediationMistakes.com

    Connect with Us

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    41 mins
  • Doctor Explains How Toxins Destroy the Gut Lining - Dr. Nikol Hopkins
    Jan 14 2026

    In this episode, Joe Fier welcomes integrative medicine expert Dr. Nikol Hopkins for an eye-opening conversation about gut health, toxins, and the power of personalized medicine. Dr. Nikol Hopkins breaks down what “leaky gut” really means, why gut health is more than just what you eat, and how environmental toxins can disrupt your body’s natural balance. Personal stories and simple analogies make this episode a must-listen for anyone seeking practical steps to support their gut, minimize toxic exposure, and understand testing options for optimal health.

    Topics Discussed

    1. The Importance of Gut Health: Why the gut is the body’s gatekeeper, its protective lining, and what happens when it’s compromised.
    2. Leaky Gut Explained: What intestinal permeability means, how it’s connected to inflammation, and why it matters for whole-body health.
    3. Toxins and Their Impact: Which toxins (mycotoxins, heavy metals, PFAs) are most disruptive to gut health, and how they infiltrate the body through food and environment.
    4. Common Culprit Foods: The five most likely foods to trigger issues—dairy, corn, soy, sugar, and wheat—and how elimination programs can provide clarity.
    5. Mycotoxins in Food and Coffee: Surprising sources of mold toxins, including grains and coffee, and why even quality roasting doesn’t always protect you.
    6. How to Heal and Support the Gut: Practical steps including elimination diets, supplements, and the power of personalized testing.
    7. Testing & Interpreting Data: The value of toxin panels and personalized analysis to create an effective avoidance and healing strategy.
    8. Everyday Detox Strategies: How to start reducing exposure—like swapping out plastic kitchenware, nonstick pans, and processed foods for safer alternatives.
    9. Taking Action in Your Home: Step-by-step advice for making your space healthier, from air and water purification to investigating food packaging choices.
    10. The Role of Personalized Medicine and TPE: How Therapeutic Plasma Exchange (TPE) and MD Lifespan’s protocols can be a next step for those at the end of their rope with chronic illness.
    11. Advocating for Your Health: Why you have to be your own health advocate in today’s world and take small steps to protect you and your family.

    Resources Mentioned

    1. Super Gut by Dr. William Davis: https://drdavisinfinitehealth.com/product/super-gut/
    2. Environmental Working Group (EWG): https://www.ewg.org/
    3. Made Safe:
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    46 mins
  • The 5 Episodes That Changed How We Think About Toxins, Health, and Healing
    Dec 24 2025

    What if optimizing your health wasn’t just about diet, exercise, or the latest supplement, but hinged on the very “oil” running through your system? In this recap episode of the TPE Blueprint Podcast, host Joe Fier is back at some of our most impactful episodes of the year. We’ll take a look at conversations with Dr. Paul Savage, Dr. Jill Carnahan, Dr. Paul Anderson, Dr. Janet Eng, and Dr. Muhammad Mansour, to break down therapeutic plasma exchange (TPE), mitochondria’s critical role in health, toxic burden from mold, and actionable strategies for real healing. Whether you’re biohacking or desperate for answers, this episode digs beneath the surface to challenge conventional medicine and empower your physiological reset.

    Topics Discussed

    1. What Is Plasma Exchange? Dr. Paul Savage breaks down the history and modern mechanics of TPE—and why it’s not a fad.
    2. The Car Analogy for Your Health: How your body’s plasma exchange is like an oil change for your engine, and why cellular “cleanliness” matters.
    3. Mitochondria & Cellular Mechanics: The role of mitochondria in energy production and disease, with Joe Fier and guests highlighting how toxins can slow you down at the cellular level.
    4. The Menace of Mold: Dr. Jill Carnahan explains mold’s surprisingly high prevalence, why genetics matter, and how environmental toxins can disrupt everything from your cardiovascular system to your hormones.
    5. Building and Environmental Health:Modern building trends and errors that lead to hidden water intrusion—and how your home’s design may affect your well-being.
    6. Assessment and Personalized Care: Dr. Janet Eng and Dr. Muhammad Mansour discuss unique approaches to evaluating metabolism, body composition, and toxic burden, emphasizing a multimodal, tailored plan for every patient.
    7. Advanced Therapies & Testing: From blood and urine screens to light therapies, what works and why there isn’t a “silver bullet” in recovery.
    8. Sympathetic Overdrive & Parasympathetic Healing: How modern stress affects our ability to heal, and practical tactics to shift toward true rest and recovery.

    Full Episodes to Check Out

    1. Dr. Paul Savage: https://mdlifespan.com/tpe-bp-podcast/tpe-blueprint-ep-03-what-is-plasma-exchange-a-deep-dive-with-dr-paul-savage/
    2. Dr. Jill Carnahan: https://mdlifespan.com/tpe-bp-podcast/tpe-blueprint-podcast-ep-19-is-mold-behind-your-fatigue-brain-fog-dr-jill-carnahan-unpacks-the-hidden-epidemic-breakthrough-detox-solutions/
    3. Dr. Paul Anderson:
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    22 mins
  • Avoid Toxins: Easy Produce Picks and Cleaning Tricks for Daily Health
    Dec 16 2025

    In this episode, Joe Fier explores the ins and outs of reducing exposure to pesticides through smart produce shopping and cleaning. Drawing on the latest research from the Environmental Working Group (EWG), Joe Fier clarifies which fruits and vegetables you should always buy organic (the "Dirty Dozen"), which are safer when conventionally grown (the "Clean 15"), and simple, effective ways to wash your produce at home. The episode also touches on hidden toxins in pantry staples, especially crucial for kids and those focused on detox or hormone support. Listeners get actionable steps to shop smarter, clean better, and support long-term health.

    Topics Discussed
    • Understanding the "Dirty Dozen" and "Clean 15" produce lists
    • Why some fruits and veggies have more pesticide residues than others
    • 2025 updates: new additions to both lists
    • Cost-saving strategies for organic and conventional produce
    • Step-by-step guide to washing produce to reduce pesticide exposure
    • Myth-busting: What washing produce can and cannot eliminate
    • Hidden toxins in pantry staples like rice-based baby foods
    • The link between everyday toxins and chronic health issues
    • Simple action plan for shopping, cleaning, and tracking health
    • How to assess your toxin burden and personalize your health approach

    Resources Mentioned

    • Environmental Working Group (EWG) Produce Lists: https://www.ewg.org/foodnews/
    • MDLifespan Blog Post: https://mdlifespan.com/dirty-dozen-clean-fifteen-2025/

    Timestamps

    00:00 Welcome to the TPE Blueprint

    01:01 The 2025 Dirty Dozen

    01:36 The 2025 Clean Fifteen

    02:06 Smart Cart Strategy

    02:22 At Home Cleaning

    02:52 Quick Myth Check

    03:12 What About Beyond Produce

    03:50 Simple Action Plan

    04:26 Get a Free Consult

    04:56 Closing

    Connect with Us

    • MDLifespan Website: https://mdlifespan.com/
    • Subscribe and Listen: https://mdlifespan.com/the-tpe-blueprint-podcasts/
    • Guidebooks: https://mdlifespan.com/guidebooks/
    • Follow on Instagram: https://instagram.com/mdlifespan
    • MDLifespan Toxin Testing: https://mdlifespan.com/toxin-test
    • Use code “podcast200” for a discount.

    Like what you heard? Screenshot the Dirty Dozen and Clean 15 lists to make your next shopping trip easier! Don’t forget to subscribe on your favorite podcast platform and drop us a comment about your own strategies for minimizing toxins. Your journey to cleaner, healthier eating starts here—join us!

    Disclaimer: MDLifespan PlasmaXchange protocols are designed to support general health and wellness. They are not intended to diagnose, treat, cure, or prevent any disease. The information provided on this podcast is for educational purposes only and should not replace medical advice. Please consult with your healthcare provider before beginning any new health program, especially if you have a medical condition or are taking prescribed medications.

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    5 mins
  • Is Your Morning Coffee Making You Sick?
    Dec 10 2025

    In this insightful episode of the TPE Blueprint Podcast, Joe Fier takes listeners on a deep dive into the hidden world of mold and mycotoxins in coffee. He explores how these contaminants can sneak into even high-quality beans, what impact they may have on your health, and practical steps you can take to enjoy your daily brew with greater confidence. Whether you’re a passionate coffee drinker or just looking to make healthier choices, you’ll learn why quality matters—and how to choose safer options for yourself and your family.

    Topics Discussed

    • What are mycotoxins, and how do they end up in coffee beans?
    • The two most common coffee mycotoxins: aflatoxin B1 and ochratoxin A—how they affect your health
    • How coffee production methods (wet and dry processing) influence mold risk
    • The role of storage, shipping, and climate control in mold contamination
    • Health impacts of mycotoxins: fatigue, brain fog, inflammation, and chronic conditions
    • Misconceptions about coffee roasting and mold/mycotoxin destruction
    • How to choose coffee brands that test for mold and mycotoxins
    • Tips for storing coffee at home to avoid unwanted mold growth
    • The importance of personal toxin testing and available tools to evaluate exposure
    • Resources for further learning and taking proactive steps for better health

    Resources Mentioned

    • MDLifespan Guidebooks: https://mdlifespan.com/guidebooks
    • MDLifespan Toxin Testing: https://mdlifespan.com/toxin-test
    • Use code “podcast200” for a discount.

    Connect with Us

    • MDLifespan Website: https://mdlifespan.com/
    • Subscribe and Listen: https://mdlifespan.com/the-tpe-blueprint-podcasts/
    • Guidebooks: https://mdlifespan.com/guidebooks/
    • Follow on Instagram: https://instagram.com/mdlifespan

    Love your morning coffee? Take charge of your health by choosing brands committed to testing and transparency. Subscribe to the TPE Blueprint Podcast for more actionable insights—and share this episode with a friend who deserves a safer cup!

    Disclaimer:

    MDLifespan PlasmaXchange protocols are designed to support general health and wellness. They are not intended to diagnose, treat, cure, or prevent any disease. The information provided on this podcast is for educational purposes only and should not replace medical advice. Please consult with your healthcare provider before beginning any new health program, especially if you have a medical condition or are taking prescribed medications.

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    7 mins
  • Groundbreaking Protocols for Removing Environmental Toxins and Boosting Lifespan
    Dec 2 2025

    In this episode, Dr. Savage pulls back the curtain on just how pervasive environmental toxins have become, why traditional functional medicine approaches are struggling, and shares a scientifically validated protocol for “changing the paradigm” in personal health. If you’re tired of hearing the same old advice and ready to reclaim your well-being, this is the talk you need.

    Topics Discussed

    • The history and evolution of Dr. Paul Savage’s career, from trauma care to pioneering natural hormone clinics
    • The alarming rise of toxin exposure in the U.S. and globally, affecting all age groups and contributing to generational health issues
    • Limitations of conventional detox methods in removing persistent toxins like PFAS and microplastics
    • The World Health Organization’s recognition of environmental toxins as the leading global cause of death
    • The direct link between toxins, chronic inflammation, and over 200 diseases
    • Introduction to therapeutic plasma exchange (TPE) as a highly effective “oil change” for the human body
    • MDLifespan’s innovative, patented protocol combining TPE with functional medicine and regenerative therapies
    • Real-world case studies demonstrating dramatic improvements in toxin levels, immune function, cognitive health, and resilience against chronic disease
    • Practical strategies for minimizing toxin exposure in daily life
    • The shift in medical philosophy: Why what you remove from your body matters more than what you add

    Connect with Us

    • MDLifespan Guidebooks: https://mdlifespan.com/guidebooks
    • MDLifespan Toxin Testing: https://mdlifespan.com/toxin-test
    • Use code “podcast200” for a discount.
    • Visit our website: TPE Blueprint Podcast

    If you found this episode eye-opening, help us spread the word! Subscribe to the TPE Blueprint Podcast for more expert interviews, actionable tips, and the latest breakthroughs in personalized health. Your journey to feeling your best starts here—don’t miss an episode!

    Disclaimer:

    MDLifespan PlasmaXchange protocols are designed to support general health and wellness. They are not intended to diagnose, treat, cure, or prevent any disease. The information provided on this podcast is for educational purposes only and should not replace medical advice. Please consult with your healthcare provider before beginning any new health program, especially if you have a medical condition or are taking prescribed medications.

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    14 mins
  • Why Today’s Toxin Levels Make Old Detox Methods Useless - Dr. Paul Savage
    Nov 25 2025

    In this insightful episode of the TPE Blueprint Podcast, host Joe Fier welcomes Dr. Paul Savage from MDLifespan to dive deep into the world of personalized toxin testing and targeted detox protocols. Dr. Savage, drawing on 35 years of experience, breaks down why our modern environment leaves us all supersaturated with toxins, why old detox methods aren’t enough, and how personalized approaches can help restore vitality. Through relatable analogies and practical advice, listeners will learn how chronic toxin exposure is linked to rising modern diseases and what steps can be taken to reduce their impact. This episode is packed with expert explanations, actionable steps, and hope for healthier living.

    Topics Discussed

    • The Escalating Problem of Environmental Toxins
    • Evolution of environmental toxins over the last 50 years
    • The difference between detox challenges 20 years ago vs. today
    • Toxin Testing: Why Personalization Matters
    • The importance of understanding your individual toxic load and specific toxin types
    • How toxins act like embers that keep re-igniting “health fires” in the body
    • The difference between inflammation and oxidation
    • Toxins’ negative effects on DNA, immune system, and chronic disease prevalence
    • The Role of Genetics and Family History
    • How your DNA affects detox pathways and susceptibility to toxins
    • Details on the three-phase approach: detoxification, regeneration, and maintenance
    • Practical Steps for Everyday Detox

    Resources Mentioned
    • MDLifespan Guidebooks: https://mdlifespan.com/guidebooks
    • MDLifespan Toxin Testing: https://mdlifespan.com/toxin-test
    • Use code “podcast200” for a discount.
    • 3x4 Genetics: https://3x4genetics.com/
    • Goop: https://goop.com/

    Enjoyed the episode? Don’t miss out on practical health strategies and the latest longevity science!

    Connect with Us

    • MDLifespan Website: https://mdlifespan.com/
    • Subscribe and Listen: https://mdlifespan.com/the-tpe-blueprint-podcasts/
    • Guidebooks: https://mdlifespan.com/guidebooks/
    • Follow on Instagram: https://instagram.com/mdlifespan

    Subscribe to the TPE Blueprint Podcast on your favorite platform, share with a friend who cares about optimizing their health, and leave us a review to let us know what you found most helpful.

    Disclaimer

    MDLifespan PlasmaXchange protocols are designed to support general health and wellness. They are not intended to diagnose, treat, cure, or prevent any disease. The information provided on this podcast is for educational purposes only and should not replace medical advice. Please consult with your healthcare provider before beginning any new health program, especially if you have a medical condition or are taking prescribed medications.

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    28 mins
  • The Power of Data: Tracking Toxins and Transforming Health Habits - Sarah Collins & Jessica Rafaeil
    Nov 18 2025

    Feeling healthy but still tired, foggy, or inflamed? In this insightful episode of the TPE Blueprint Podcast, host Joe Fier welcomes Sarah Collins and Jessica Rafaeil from MDLifespan for an open conversation about battling toxins. Both guests share their personal toxin test journeys, strategies for detoxing, and the real-world impact on their lives. You’ll learn how two different approaches, avoidance and more clinical intervention, can shape your path to better energy and well-being. If you’re curious about what might be lurking in your environment and how to get clarity, this is the episode for you!

    Topics Discussed

    • Personal Toxin Awareness: How Sarah Collins and Jessica Rafaeil came to understand environmental toxins, even while living healthy lifestyles
    • The Toxin Test: What it is, how it works, and the surprising findings in their own results
    • Sources of Everyday Toxins: Where toxins hide in our food, homes, water, personal care products, and environments
    • Parenting & Toxins: How toxin awareness is shaping choices for family, especially with young children
    • Two Detox Approaches...
    • Jessica Rafaeil's Approach: Avoidance tactics (clean food, water, air, products) and lifestyle detox methods (saunas, binders, nutrition)
    • Sarah Collins Approach: Medical treatments (TPE/Plasma Exchange), avoidance measures, and integrative health support
    • Making Detox a Lifestyle: How shifting perspective from quick cleanses to ongoing, incremental changes led to significant results
    • Results & Reflections: Emotional reactions to test results, challenges with family and social pressures, and successes reducing toxin loads
    • Tools for Action: Using apps and professional guidance to make smarter toxin-free choices

    Resources Mentioned

    • Get Your Toxin Test: https://tests.mdlifespan.com/toxin-test and get $200 off with code: PODCAST200
    • Guidebooks: https://mdlifespan.com/guidebooks/
    • YUKA App: https://yuka.io/en/
    • Germ Guardian Air Purifiers:
    • GOOP Beauty Products: https://goop.com/
    • Activated Charcoal Supplement
    • Infrared Sauna Therapy

    Connect with Us

    • MDLifespan Website: https://mdlifespan.com/
    • Subscribe and Listen: https://mdlifespan.com/the-tpe-blueprint-podcasts/
    • Guidebooks: https://mdlifespan.com/guidebooks/
    • Follow on Instagram: https://instagram.com/mdlifespan

    Ready to turn awareness into action? Subscribe to the TPE Blueprint Podcast so you never miss insights, expert tips, or real-life stories to help you on your journey to better health. Every episode brings you a fresh perspective—take the first step today and join our growing community!


    Disclaimer MDLifespan PlasmaXchange protocols are designed to support general health and wellness. They are not intended to diagnose, treat, cure, or prevent any disease. The information provided on this podcast is for educational purposes only and should not replace medical advice. Please consult with your healthcare provider before beginning any new health program, especially if you have a medical condition or are taking prescribed medications.

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    43 mins