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The Synapse and the Stoa: Psychology & Stoic Philosophy

The Synapse and the Stoa: Psychology & Stoic Philosophy

Written by: John Sampson | Science-Based Self-Help
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About this listen

Explore the intersection of modern psychology and ancient Stoic philosophy with The Synapse and the Stoa, a science-based self-help podcast hosted by John Sampson. Each episode bridges the gap between neuroscience and timeless wisdom to provide practical tools for mental resilience and personal growth.

In a world of surface-level advice, we go deeper. By examining the neural pathways of the 'Synapse' and the timeless logic of the 'Stoa', we unpack why we think, feel, and act the way we do. Whether you're struggling with burnout, seeking better habits, or simply curious about the human condition, this show provides a roadmap for the modern seeker.

New episodes drop every Tuesday at 5:00 AM - perfect for your morning commute or early gym session.

If you find value in these episodes, please leave a 5-star review on Spotify or Apple Podcasts. It helps a solo show like this reach more people.

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Philosophy Self-Help Social Sciences Success
Episodes
  • The Necessary Friction: Stoic Secrets to Perseverance After a Setback
    Jan 20 2026

    Are you struggling to get back on track after a failed goal or a broken New Year's Resolution? You set a big goal—a new career, better fitness, a serious habit—but the inevitable setback crushed your momentum. Most people quit here. But the most successful people understand that this "friction" is a required step, not a sign of failure.

    In this deep-dive episode of Weekly Wisdom with John Sampson, we explore the ancient philosophy, modern psychology, and hard neuroscience that provides a proven roadmap to turn setbacks into your greatest fuel.

    In this episode, you will learn:

    • The Stoic Dichotomy of Control: How to instantly reframe a setback by separating what you can control (your attitude, your effort) from what you cannot (the past outcome).
    • The Neurobiology of Self-Compassion: Why beating yourself up after a failure is the worst possible strategy, and how kindness is the most powerful catalyst for future achievement and strong perseverance.
    • Nietzsche’s "Long Obedience": Why anything worth pursuing must be difficult, and how to embrace the struggle as the very definition of a meaningful life.
    • The Aristotelian Truth: Why true flourishing (Eudaimonia) is not a destination but a continuous activity, making sustained effort (perseverance) mandatory.
    • 3 Practical Tools for Unstoppable Discipline: Actionable steps—including the Stoic Pause and the Process Goal—to immediately integrate these lessons and guarantee success in your most challenging goals.

    Don't let a temporary dip define your future. It's not over until you give up. Tune in and discover how to use the "necessary friction" to achieve your major life goals.

    Subscribe to Weekly Wisdom with John Sampson for practical solutions that merge philosophy, psychology, and neuroscience every week.

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    24 mins
  • Stop The Chase for "More" | Stoic Philosophy, Neuroscience, & Finding What is Enough
    Jan 13 2026

    This week, we tackle the relentless psychological burden of Status Anxiety and the central question: What is Enough?

    We all feel the pull of the Hedonic Treadmill, constantly chasing more success, money, and recognition, only to find contentment always out of reach. If you don't define What is Enough, nothing ever will be.

    In this powerful episode, John Sampson fuses ancient Stoic Philosophy (Epictetus, Marcus Aurelius, Seneca) and modern Neuroscience to reveal the toxic loop that keeps your brain trapped in a state of Never Enough.

    You will learn:

    • 🧠 The Psychological Trap: What happens in your brain (the amygdala & HPA axis) when you are constantly chasing status, and how Hedonic Adaptation keeps you running up a hill to nowhere.
    • 🏛️ Ancient Keys to Self-Discipline: Wisdom from Marcus Aurelius on reputation and Seneca on voluntary poverty to build an Internal Citadel of sufficiency.
    • ⚠️ The High Cost of Fame: Cautionary tales from the lives of Robin Williams, Heath Ledger, and Matthew Perry that prove external success does not equal internal peace.
    • Practical Steps: A clear, four-step plan to define your true "enough," overcome comparison, and gain true Self-Discipline.

    Stop letting external validation control you. It's time to win the war against Status Anxiety.

    SUBSCRIBE for more Weekly Wisdom every week!

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    26 mins
  • Discipline Equals Freedom: The Neuroscience of Unbreakable Self-Control, Stoic Wisdom, and How to Grow Your aMCC
    Jan 6 2026

    Tired of Akrasia (weakness of will)? Learn how the mantra "Discipline Equals Freedom" is supported by cutting-edge brain science and ancient Stoic wisdom.

    This episode provides a complete breakdown of self-mastery, explaining why you struggle and giving you the tools to stop. We dive deep into the Neuroscience of Self-Discipline, revealing the battle between your impulsive limbic system and your Prefrontal Cortex (PFC). You’ll discover the critical brain region for effort—the Anterior Mid-Cingulate Cortex (aMCC)—and the scientific studies showing how engaging in hard things (Askēsis) can cause this area to literally grow (neuroplasticity), making self-control automatic.

    We explore the philosophical roots of Temperance and Delayed Gratification from Plato and Seneca. Crucially, we deliver four immediate, actionable steps to rewire your habits, including:

    • Environmental Engineering to remove temptation.
    • Using Implementation Intentions to automate action.
    • Protecting your willpower by managing Cognitive Load and Stress.

    Start building your Inner Citadel today. Listen now to unlock unbreakable self-control and achieve true self-mastery.

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    27 mins
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