Showing results for "Calcium" in Physical Illness & Disease
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Integrative Computational Modeling of Calcium Handling and Cardiac Arrhythmias
- Written by: Henry Sutanto
- Original Recording
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Cardiomyocyte calcium handling is a major determinant of excitation-contraction coupling. Alterations in one or more calcium-handling proteins may induce arrhythmias through the formation of ectopic activity, direct and indirect ion-channel regulation, and structural remodeling. Due to the complex and tight interactions between calcium and other molecules within a cardiomyocyte, it remains experimentally challenging to study the exact contributions of calcium-handling abnormalities to arrhythmogenesis. Multiscale computational studies performed in close collaboration with laboratory ...
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