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Raymond Francis is the scientist people turn to when diets don’t work. His groundbreaking approach treats excess weight for what it really is—a disease caused by malfunctioning cells. As Francis explains, many of the foods we eat every day, especially the “health” and “diet” ones we dutifully buy to lose weight, have the opposite effect. Full of hidden toxins and lacking nutrients, they actually poison your cells and alter your weight-control genes, causing your body to put on the pounds.

Jim Gaffigan never imagined he would have his own kids. Though he grew up in a large Irish-Catholic family, Jim was satisfied with the nomadic, nocturnal life of a standup comedian, and was content to be "that weird uncle who lives in an apartment by himself in New York that everyone in the...