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Three of the most important words in science are I don't know. Not knowing implies a universe of opportunities—the possibility of discovery and surprise. Our understanding of science has advanced immeasurably over the last 500 years, yet many fundamental mysteries of existence persist: How did our universe begin? How big is the universe? Is time travel possible? What’s at the center of a black hole? How did life on Earth arise? Are we alone? What is consciousness, and can we create it?

Delve into the exciting field of “epistemology”, the philosophical term for our inquiry into knowledge: what it is, the ways we acquire it, and how we justify our beliefs as knowledge. Taught by acclaimed Professor Joseph H. Shieber of Lafayette College, these 24 mind-bending lectures take you from ancient philosophers to contemporary neurobiologists, and from wide-ranging social networks to the deepest recesses of your own brain.