BREAKING THROUGH with Madeline Bell cover art

BREAKING THROUGH with Madeline Bell

BREAKING THROUGH with Madeline Bell

Written by: Children’s Hospital of Philadelphia
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Madeline Bell, CEO of the renowned Children’s Hospital of Philadelphia, takes you behind the scenes to meet the brilliant minds who are making - and supporting - incredible breakthroughs in pediatric medicine.Copyright 2023 All rights reserved. Hygiene & Healthy Living Physical Illness & Disease
Episodes
  • Game Plan for Giving Back: Philadelphia Eagles President Don Smolenski
    Jan 23 2026

    For Philadelphia Eagles President and longtime Children’s Hospital of Philadelphia (CHOP) volunteer Don Smolenski, success is built on trust and care – and connecting with the community means everything. In the new episode of Breaking Through, Don joins Madeline to talk about what the team means to the city – and what makes the partnership between the Eagles and CHOP so special. It’s an inspiring conversation that highlights how a collaboration built on shared values can make a difference for an entire community.

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    18 mins
  • Advancing Gene Therapy: Personalized Gene Editing
    Oct 13 2025

    When baby KJ was diagnosed with a rare metabolic disorder, the team at Children’s Hospital of Philadelphia (CHOP) had a unique treatment option for him: a personalized gene editing therapy developed in collaboration with Penn Medicine. On this episode, Madeline speaks to CHOP geneticist Dr. Rebecca Ahrens-Nicklas, who describes how KJ’s first-of-its-kind treatment was developed – and what this amazing breakthrough means for other patients.

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    22 mins
  • Advancing Gene Therapy: KJ’s Story
    Aug 22 2025

    Earlier this year, baby KJ became the first patient in the world to receive a personalized gene editing therapy, which was developed by a team at Children’s Hospital of Philadelphia (CHOP) and Penn Medicine. In June, KJ went home after spending more than 300 days at CHOP. On this episode of Breaking Through, Madeline speaks to KJ’s parents, Kyle and Nicole, about the treatment that changed KJ’s life – and how he’s doing today.

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    32 mins
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