David Schatz talks about his discovery of Rag genes that are critical for antigen receptor development and how that discovery depended on taking high risks and using approaches that everyone thought could never work.

Host: Cindy Leifer

Guest: David Schatz

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• MicrobeTV Discord Server
• Transfer of recombinase activity in non-lymphoid cells (Cell 1988)
• Identification of the RAG-1 gene (Cell 1989)
• Evolution of a recombinase (Semin Immunol 2004)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Information on this podcast should not be construed as medical advice.

The Immune team discusses the groundbreaking discoveries of regulatory T cells, which was the topic of the 2025 Nobel Prize in Physiology or Medicine.

Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker

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• MicrobeTV Discord Server
• Sakaguchi lab paper on FoxP3 and regulatory T cells (Science 2003)
• Brunkow and Ramsdell description of scurfy mouse mutation (Nature 2001)
• Nobel Prize writeup on Treg discoveries
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Susan Schwab talks about how she got the research bug, bugs she ate, and her research on how the lipid S1P helps T cells decide- should I stay or should I go.

Host: Cindy Leifer

Guest: Susan Schwab

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• MicrobeTV Discord Server
• Schwab lab website
• Monocytes produce the lipid S1P to regulate T cell movement
• Review on S1P and immune cell migration
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.