Dr. Amy Tiffany sits down with board-certified endocrinologist Dr. Neeli Singh to unpack why your labs can be normal while you feel completely off, what actually happens when you microdose a GLP-1, and why the weight you lose on these medications isn't all fat.
Dr. Singh is board-certified in Endocrinology, Internal Medicine, Lifestyle Medicine, and Obesity Medicine, a Menopause Society Certified Practitioner, and the founder of EndoHarmony — a direct-care endocrinology practice offering 90-minute visits, in person in Westborough, Massachusetts and virtually across MA, NH, NY, ME, MD, and AR.
After 20+ years with Mass General Brigham, she left the 20-minute-appointment system to build a practice around root causes instead of rushed protocols.
This conversation is for women 35 to 55 who are doing everything right and still gaining weight, anyone on or considering a GLP-1 medication, and every woman who's been told her thyroid is "fine" while she feels anything but.
After watching, you'll understand why thyroid doses shift during perimenopause and how oral estrogen changes your medication needs, how GLP-1s actually work in the body and how to protect your muscle while taking them, why binge eating disorder is a brain condition rather than a willpower failure, and how to eat with your cycle instead of fighting it.
Timestamps:
0:00 – Who is Dr. Neeli Singh, and what does an endocrinologist treat?
3:18 – Why did a Mass General Brigham endocrinologist build her own practice?
4:17 – What is lifestyle medicine, and how is it different from functional medicine?
6:42 – Why lifestyle medicine is really "the medicine of your habits"
7:03 – Did functional medicine find the thyroid problem your endocrinologist missed?
9:29 – Why did patients stop trusting doctors — and did COVID cause it?
11:59 – Who is Dr. Singh without the credentials?
13:43 – Why she left Mass General Brigham after 20 years
15:25 – 20-minute appointments vs. 90-minute visits: what direct care changes
17:26 – Why does your thyroid dose keep changing in perimenopause?
19:27 – How do GLP-1 medications like Ozempic actually work?
21:19 – Are you losing muscle on your GLP-1? How to protect it
22:31 – GLP-1s, PCOS, and pregnancy: what women need to know
24:13 – Does microdosing Ozempic actually work? An endocrinologist answers
26:06 – Are compounded GLP-1s safe?
27:08 – The eating disorder 99% of people don't know they have
30:14 – How your menstrual cycle changes cravings and blood sugar
33:20 – How to eat with your cycle (luteal phase strategy)
36:46 – Does an IUD or ablation stop your cycle? What's really happening
38:33 – Gestational diabetes: the warning most women never get
43:30 – How to work with Dr. Singh at EndoHarmonyConnect with
Dr. Neeli Singh:
🔗 Website: https://endo-harmony.com
📋 Find a certified menopause practitioner: https://menopause.org
Connect with Dr. Amy Tiffany:
🌐 Website: vitalitymwc.org
📱 Instagram: @dramytiffany
💼 LinkedIn: Dr. Amy Loden Tiffany
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Microdosing a GLP-1 medication means staying on the lowest effective dose to maintain weight loss, and it works when supervised by a physician.
Weight lost on GLP-1 medications includes muscle, so adults on these drugs need 30 to 40 grams of protein per meal and strength training three to four times per week.
Binge eating disorder is the most common eating disorder in the United States, and most people who have it are never diagnosed.
About one in three women who have gestational diabetes will develop type 2 diabetes, which is why screening should continue for life.