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The Big Unlock

The Big Unlock

Written by: Rohit Mahajan & Ritu M. Uberoy
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THE BIG UNLOCK PODCAST is a Healthcare Digital Transformation Podcast. Stay Updated on Healthcare’s Digital Transformation Trends. Featuring C-suite Leaders and Insights on Digital Health Innovation. Explore Emerging Healthcare Technologies with Rohit Mahajan and Ritu M. Uberoy.© 2025 The Big Unlock Podcast
Episodes
  • Episode 231 – Healthcare Innovation Demands a Culture That Fears Inaction, Not Failure
    Oct 20 2026
    The Big Unlock · Dr. Richard Zane, Chief Medical Officer and Chief Innovation Officer, UCHealth

    In this episode, Dr. Richard Zane, Chief Medical Officer and Chief Innovation Officer at UCHealth, discusses how AI and emerging technologies can improve clinical decision-making, expand access to care, and enable scalable healthcare innovation.

    Dr. Zane emphasizes that successful innovation begins with problems identified by frontline teams, not technology looking for applications. He explains how AI’s strengths in pattern recognition and complex data analysis can support better decisions, while human judgment remains essential in clinical care. He shares an approach to partnering with technology companies, co-developing solutions, and designing for scale. He also discusses how technology can bring complex care closer to rural communities, supported by appropriate clinical safeguards.

    Dr. Zane advocates replacing traditional pilots with phased deployments, rapid iteration, and continuous improvement. His message to healthcare leaders is to prioritize patient needs, fear inaction rather than failure, and focus on technology that delivers meaningful value. Take a listen.

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    23 mins
  • Episode 228 – AI-Powered Health Discovery and the Path to Care
    Sep 29 2026
    The Big Unlock · Ann Bilyew, President, WebMD Ignite

    In this episode, Ann Bilyew, President at WebMD Ignite, explores how the rise of AI-generated health information is changing the way health systems connect consumers to care. As LLMs increasingly own the information layer, she argues that the opportunity for healthcare organizations is shifting from owning search and discovery to establishing credibility and owning the handoff from a patient’s question to the right care.

    Ann emphasizes the importance of complete, credible, and corroborated content, alongside personalized engagement that reflects each patient’s clinical circumstances, preferences, and needs. She also calls for reducing friction and breaking down organizational and technology silos across marketing, education, engagement, and care to create a more cohesive patient journey. Ann believes healthcare organizations must focus on creating the connection point between foundational AI models and the actual provision of care. Take a listen.

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    23 mins
  • Episode 229 – Agentic AI Can Expand Access to Primary Care
    Oct 6 2026
    The Big Unlock · Jean-Claude Saghbini, Chief Technology Officer and President of Technology Services, Lumeris

    In this episode, Jean-Claude Saghbini, Chief Technology Officer and President of Technology Services at Lumeris, explores how agentic AI can help address healthcare’s primary care access challenge. He argues that incremental efficiencies are not enough; AI must enable the existing clinical workforce to serve more patients and extend care between visits.

    Jean-Claude discusses Tom, Lumeris’ AI-powered primary care team member and operating system, which uses patient data to identify next actions and proactively engage patients. He emphasizes that deploying Agentic AI responsibly requires clear guidelines for what AI should do and guardrails for what it cannot do.

    Jean-Claude argues that AI models themselves will not create competitive advantage. Differentiation will come from data, domain knowledge, applications, and redesigned workflows. He advises healthcare technology leaders to move beyond the automation, pilot, and perfection traps and make focused enterprise AI investments. Take a listen.

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    21 mins
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