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The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

Written by: Dave Asprey
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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

© Copyright © Bulletproof Media 2023 Hygiene & Healthy Living Science Self-Help Success
Episodes
  • Your Brain Has a Focus Switch (Here's How to Turn It On) : 1553

    Your Brain Has a Focus Switch (Here's How to Turn It On) : 1553
    Oct 11 2026

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    This video reveals that the brain has a documented neurological focus state driven by prefrontal cortex activation and norepinephrine signaling that most people access accidentally but can learn to trigger reliably. Dave explains the biological mechanism and the specific supplement and behavioral stack that activates this state within 20 minutes.


    You'll Learn:

    • Why your brain has a neurochemical "focus switch" and how to flip it on in about 20 minutes, with no extra willpower or motivation
    • How norepinephrine and dopamine work together to lock you into deep focus, and what happens when only one of them is present
    • Why chronic stress, poor sleep, and sitting all day drain the exact chemicals your focus depends on
    • How L-tyrosine gives your brain the raw materials to make focus chemicals, and the dose and timing that work
    • Why the 1:2 ratio of caffeine to L-theanine beats coffee alone for working memory, accuracy, and calm, sustained concentration
    • Which options like modafinil and Rhodiola rosea support norepinephrine and dopamine, and how they compare
    • How morning light and five minutes of movement set your focus chemistry for the entire day
    • Why focus is never about effort, and how the right chemistry makes deep work feel effortless


    Thank You To Our Sponsors:

    -Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh

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    Timestamps:

    00:00 — The Focus Switch

    01:44 — Habit One: Chronic Stress

    03:38 — Habit Two: Bad Sleep

    04:58 — Habit Three: Sitting

    06:21 — Norepinephrine and Dopamine

    09:40 — L-Tyrosine

    10:41 — Caffeine and L-Theanine

    12:30 — Modafinil and Rhodiola

    14:42 — The 20-Minute Protocol

    17:34 — The Right Fuel


    Connect with Dave Asprey!

    Website: https://daveasprey.com

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    YouTube: https://www.youtube.com/c/daveaspreybpr


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    19 mins
  • Infections & Cancer, Finasteride Side Effects, Blueberry Benefits, Vitamin D & Fertility, and CoQ10 : 1552

    Infections & Cancer, Finasteride Side Effects, Blueberry Benefits, Vitamin D & Fertility, and CoQ10 : 1552
    Oct 9 2026
    Infections Were Linked to About 1 in 8 Cancer Cases Worldwide A new global analysis estimates that infections were responsible for roughly 2.3 million new cancer cases in 2024, about 12% of all cancers worldwide. H. pylori and HPV were the largest contributors, followed by hepatitis B, Epstein-Barr virus, and hepatitis C. Host Dave Asprey explores how persistent infections can contribute to cancer through chronic inflammation, DNA damage, altered immune surveillance, and other biological pathways. He explains why this does not mean cancer is contagious or that infection inevitably leads to cancer, but argues that identifying, preventing, and treating infections such as H. pylori, hepatitis B, and hepatitis C can be an overlooked part of a long-term prevention strategy. Sources: -IARC: Global Burden of Cancer Attributable to Infections in 2024 -PubMed: Global Burden of Cancer Attributable to Infections in 2024 ~~~~ What We Really Know About Persistent Finasteride Side Effects Finasteride reduces the conversion of testosterone into DHT by inhibiting 5-alpha reductase, but that enzyme also participates in pathways involved in neuroactive steroids. Some former users report persistent sexual, cognitive, mood, and physical symptoms after stopping the drug, a collection of symptoms commonly called post-finasteride syndrome. Small studies have reported differences in neurosteroids, gene expression, androgen signaling, and peripheral nerve function among symptomatic former users, but these studies cannot establish that finasteride caused those changes or determine how common persistent symptoms are. Host Dave Asprey examines the evidence between the two extremes, neither dismissing persistent symptoms nor assuming that finasteride permanently damages everyone who takes it. European regulators have also recognized suicidal ideation as a possible adverse effect of oral finasteride, although its frequency remains unknown. Sources: -EMA: Finasteride and Dutasteride Safety Review -PubMed: Neuroactive Steroids After Finasteride Discontinuation PubMed: Neuroactive Steroids and Features in Post-Finasteride Patients PubMed: Differential Gene Expression in Post-Finasteride Syndrome ~~~ One Cup of Blueberries a Day Improved Measures of Vascular Function In a six-month randomized controlled trial involving 115 adults with metabolic syndrome, consuming the equivalent of one cup of blueberries per day improved endothelial function and a measure of arterial stiffness, while a half-cup dose did not produce the same effects. Host Dave Asprey explains why describing blueberries simply as “antioxidants” misses much of their biology. Anthocyanins and other polyphenols can interact with gut microbes and influence vascular, inflammatory, and nitric oxide-related signaling. He also examines a small smoothie experiment showing that the polyphenol oxidase found in bananas sharply reduced the circulating metabolites of certain flavan-3-ols, while emphasizing that the experiment did not prove bananas erase the benefits of blueberries. Sources: -American Journal of Clinical Nutrition: Blueberries and Cardiometabolic Function -Food & Function: Polyphenol Oxidase and Flavan-3-ol Bioavailability ~~~ Vitamin D Matters to Male Reproductive Biology, But It Is Not a Fertility Treatment Vitamin D receptors are present throughout the male reproductive system, and vitamin D signaling may influence processes involved in sperm motility and fertilization. Observational research has linked low vitamin D with poorer sperm motility, but clinical outcomes are less straightforward. In a randomized trial of 330 vitamin D-insufficient infertile men, supplementation raised vitamin D levels but did not improve overall semen parameters. Researchers observed potentially interesting signals involving spontaneous pregnancy and live birth among a subgroup of men with low sperm counts, but those findings require confirmation. Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense while arguing that male fertility needs to be evaluated as a larger system involving metabolic health, sleep, heat exposure, medications, hormones, micronutrients, toxins, oxidative stress, and semen testing. Sources: -PubMed: Vitamin D Supplementation, Semen Quality and Live Birth Rate ~~~ CoQ10 Shows Why a Great Mechanism Does Not Guarantee a Great Treatment CoQ10 plays a central role in mitochondrial energy production and electron transport, making it an appealing candidate for diseases involving mitochondrial dysfunction, oxidative stress, and neuronal energy failure. Early biological reasoning and smaller studies looked promising, but larger clinical trials have repeatedly failed to show the expected neurological benefits. A randomized trial of 600 people with early Parkinson’s disease found no evidence that high-dose CoQ10 slowed disease progression, while a large Huntington’s disease trial was stopped early for futility. A ...
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    11 mins
  • How to Unlock Psychic Abilities to Know When You’ll Die : 1551

    How to Unlock Psychic Abilities to Know When You’ll Die : 1551
    Oct 8 2026
    Get a free digital and audiobook copy of Angelic Attendants at https://askjulieryan.com/request-ebook/ Psychic Abilities, Medical Intuition, Energy Healing, Remote Viewing & What Happens When We Die with Julie Ryan Host Dave Asprey sits down with Julie Ryan, psychic, medical intuitive, inventor, author, entrepreneur, and host of the Ask Julie Ryan podcast, to explore intuition, consciousness, energetic healing, remote viewing, communication with spirits, past lives, dreams, and what Julie says happens as people approach death. Julie Ryan is a psychic and medical intuitive who says she can sense medical conditions, facilitate energetic healings, communicate with spirits, scan animals, access past lives, and tell how close someone may be to death. She is also an inventor, author, radio host, podcaster, and serial entrepreneur who has founded nine companies across five industries. Her surgical device inventions are sold globally, and unlike many people working in the intuitive space, Julie says her psychic and medical intuitive abilities were learned. Her book Angelic Attendants: What Really Happens As We Transition From This Life Into The Next explores what she describes as the process of dying, including the presence of angels, deceased family members, friends, pets, and other experiences that may occur near the end of life. Julie explains how she went from building companies and inventing surgical devices to learning psychic and medical intuitive skills she now teaches to others. She describes how she believes people can remotely sense information about the body, distinguish intuition from ordinary thoughts, and develop abilities that often get ignored or shut down as people grow older. Dave and Julie explore what it means to “scan” someone from a distance, how Julie says she perceives injuries and illness inside the body, and why she sees intuition as another form of information processing rather than something reserved for a small group of gifted people. Julie also explains why visual, auditory, and kinesthetic learners may experience intuitive information differently. They also discuss energetic healing, emotional trauma, brainwave patterns, spiritual experiences during surgery, communication with deceased loved ones, and the role dreams may play in receiving intuitive information. Dave shares his own experiences with intuition, altered brain states, grief, and the peaceful death of his mother. This episode is essential listening for anyone interested in psychic abilities, intuition, consciousness, energy healing, remote viewing, medical intuition, dreams, the afterlife, grief, near-death awareness, spirituality, neuroscience, and the possibility that human perception may extend beyond what most people are trained to notice. You’ll Learn: How Julie says psychic and medical intuitive abilities can be learned and trained How she remotely “scans” the body and interprets information about illness, injury, and healing How to tell the difference between intuition and ordinary thoughts or emotions What Julie says happens spiritually during surgery, dreams, and communication with deceased loved ones How her 12 phases of transition may indicate when someone is approaching death Why Dave believes intuition and science can overlap, especially in observation, discovery, and consciousness research Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Julie Ryan, psychic abilities, psychic powers, medical intuitive, medical intuition, intuition, intuitive abilities, energy healing, energetic healing, remote viewing, consciousness, spirituality, afterlife, what happens when you die, death and dying, near death, spirit communication, communicating with spirits, deceased loved ones, past lives, psychic training, intuitive training, spiritual healing, dreams, vivid dreams, grief, angels, guardian angels, consciousness research, neuroscience, brainwaves, psychic brain, spiritual experiences, emotional healing, energy medicine, mind body connection, holistic healing, biohacking, human potential, Dave Asprey, The Human Upgrade Resources: • Get A Free Digital And Audiobook Copy Of Angelic Attendants At https://askjulieryan.com/request-ebook/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-...
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    1 hr and 4 mins
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