In this episode we sit down with Dr. Christof Koch- one of the world’s most influential neuroscientists and a pioneer in the scientific study of consciousness. Christof has spent his career trying to understand how the brain creates our inner world: our perceptions, emotions, fears, dreams, and our very sense of self.

This conversation moves far beyond theory. We explore what consciousness feels like from the inside- how anxiety and fear arise in the brain, why psychedelics can dissolve the boundaries of the self, and what dreams reveal about the machinery of the mind. We dig into the practice of confronting one's inner demons, cultivating inner peace, and how exercise, diverse experiences, and strong community shape who we become.

Along the way, they touch on everything from evolutionary biology to the Amish, weaving science with deeply human questions about meaning, identity, and how to live a fuller life.

If you’ve ever wondered what it truly means to be human - and how the brain constructs the reality you experience - this is a conversation you won’t want to miss.

Your brain says “breathe,” but your body can’t.

In this episode, we break down how fentanyl hijacks the nervous system-shutting airways, stiffening the chest, and breaking the link between the brain and the breath. Based on two new papers from the lab, this story explains the real physiology behind opioid overdose and what it means for emergency response and recovery.

In this episode, Dr. Joel Snyder joins us to unpack his recent Nature Neuroscience paper challenging Integrated Information Theory (IIT). We dive into the limits of testability, the allure of elegant models, and whether systems like the brainstem’s respiratory rhythm generator might force us to rethink where consciousness begins.

Is dopamine really the "pleasure molecule"? Or have we been getting it all wrong? In this episode, we dive into the neuroscience behind craving, motivation, and addiction—and reveal why your brain is wired not for the reward itself, but for the pursuit of it. From social media scrolls to big life goals, we explore how dopamine shapes our habits, our happiness, and our sense of purpose.

Join us as we take a look into a new feature of fentanyl and other opioids in the body. What do they do? How do they work? And why could they be devastating? Tune in to learn.

In this episode, we explore how orexin neurons in the brain help us prioritize exercise over tempting distractions like delicious food. Discover the science behind this brain-powered 'gym coach' and learn why some people are better at resisting temptation—giving us fresh insights into motivation, decision-making, and the battle between brain and cravings.

Paper: Tesmer, A. L., Li, X., Bracey, E., Schmandt, C., Polania, R., Peleg-Raibstein, D., & Burdakov, D. (2024). Orexin neurons mediate temptation-resistant voluntary exercise. Nature Neuroscience, 1-9.

Join us as we explore the world of sleep at high altitudes. Discover how thin air impacts breathing and sleep patterns, and delve into scientific studies that shed light on how our bodies adapt to these extreme environments. Tune in to unravel the mysteries of sleeping among the stars and learn how to enhance your rest on your next high-altitude adventure.

Paper: https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP285397

Ibrahim, Abubaker, et al. "Effects of periodic breathing on sleep at high altitude: a randomized, placebo‐controlled, crossover study using inspiratory CO2." The Journal of Physiology (2024).

This week, we dive into the enigma of whether the universe is locally real, exploring the profound ways our perceptions mold reality and how neural network states govern our consciousness. Join us as we unravel the intricate dance between observation, cognition, and the very fabric of existence.